Familial aggregation of Trypanosoma brucei gambiense trypanosomiasis in a very high incidence community in Zaire

N. Khonde, J. Pépin, T. Niyonsenga, P. De Wals

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Familial aggregation of Trypanosoma brucei gambiense human African trypanosomiasis (HAT) was investigated in 3 adjacent villages of central Zaire where 318/1431 inhabitants had previously suffered from HAT. Neither spatial nor familial aggregation was detected when analysing the distribution of cases in the whole community using Poisson, negative binomial and pairwise odds ratio models. However, clustering of cases was observed when specific familial relationships were examined. The risk of HAT for a child was significantly increased if the mother had also had HAT, but it was not influenced by a past history of HAT in the father. Sisters and brothers of cases of HAT had a higher risk of HAT than siblings of individuals who had never had HAT, but no such association was documented for half-sisters and half-brothers. Among married couples, a past history of HAT in one spouse had no impact on the other spouse's risk of HAT. Indirect arguments suggested that familial clustering was a consequence of shared exposure, either sequential or simultaneous, rather than of genetic susceptibility. The existence of familial clustering should be kept in mind when implementing passive or active case-finding activities.

Original languageEnglish
Pages (from-to)521-524
Number of pages4
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume91
Issue number5
DOIs
Publication statusPublished - 1997
Externally publishedYes

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Trypanosoma brucei gambiense
African Trypanosomiasis
Democratic Republic of the Congo
Trypanosomiasis
Incidence
Siblings
Cluster Analysis
Spouses
Genetic Predisposition to Disease
Fathers

Cite this

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title = "Familial aggregation of Trypanosoma brucei gambiense trypanosomiasis in a very high incidence community in Zaire",
abstract = "Familial aggregation of Trypanosoma brucei gambiense human African trypanosomiasis (HAT) was investigated in 3 adjacent villages of central Zaire where 318/1431 inhabitants had previously suffered from HAT. Neither spatial nor familial aggregation was detected when analysing the distribution of cases in the whole community using Poisson, negative binomial and pairwise odds ratio models. However, clustering of cases was observed when specific familial relationships were examined. The risk of HAT for a child was significantly increased if the mother had also had HAT, but it was not influenced by a past history of HAT in the father. Sisters and brothers of cases of HAT had a higher risk of HAT than siblings of individuals who had never had HAT, but no such association was documented for half-sisters and half-brothers. Among married couples, a past history of HAT in one spouse had no impact on the other spouse's risk of HAT. Indirect arguments suggested that familial clustering was a consequence of shared exposure, either sequential or simultaneous, rather than of genetic susceptibility. The existence of familial clustering should be kept in mind when implementing passive or active case-finding activities.",
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Familial aggregation of Trypanosoma brucei gambiense trypanosomiasis in a very high incidence community in Zaire. / Khonde, N.; Pépin, J.; Niyonsenga, T.; De Wals, P.

In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 91, No. 5, 1997, p. 521-524.

Research output: Contribution to journalArticle

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