Features that exacerbate fatigue severity in joint hypermobility syndrome/Ehlers–Danlos syndrome - hypermobility type

Anne Maree Krahe, Roger David Adams, Leslie Lorenda Nicholson

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Aim: To assess the prevalence, severity and impact of fatigue on individuals with joint hypermobility syndrome (JHS)/Ehlers–Danlos syndrome–hypermobility type (EDS-HT) and establish potential determinants of fatigue severity in this population. Methods: Questionnaires on symptoms and signs related to fatigue, quality of life, mental health, physical activity participation and sleep quality were completed by people with JHS/EDS-HT recruited through two social media sites. Multiple regression analysis was performed to identify predictors of fatigue in this population. Results: Significant fatigue was reported by 79.5% of the 117 participants. Multiple regression analysis identified five predictors of fatigue severity, four being potentially modifiable, accounting for 52.3% of the variance in reported fatigue scores. Predictors of fatigue severity were: the self-perceived extent of joint hypermobility, orthostatic dizziness related to heat and exercise, levels of participation in personal relationships and community, current levels of physical activity and dissatisfaction with the diagnostic process and management options provided for their condition. Conclusion: Fatigue is a significant symptom associated with JHS/EDS-HT. Assessment of individuals with this condition should include measures of fatigue severity to enable targeted management of potentially modifiable factors associated with fatigue severity. Implications for rehabilitation: Fatigue is a significant symptom reported by individuals affected by joint hypermobility syndrome/Ehlers–Danlos syndrome–hypermobility type. Potentially modifiable features that contribute to fatigue severity in this population have been identified. Targeted management of these features may decrease the severity and impact of fatigue in joint hypermobility syndrome/Ehlers–Danlos syndrome–hypermobility type.

Original languageEnglish
Pages (from-to)1989-1996
Number of pages8
JournalDisability and Rehabilitation
Volume40
Issue number17
DOIs
Publication statusPublished - 2018
Externally publishedYes

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Joint Instability
Fatigue
Regression Analysis
Population
Social Media
Dizziness

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Krahe, Anne Maree ; Adams, Roger David ; Nicholson, Leslie Lorenda. / Features that exacerbate fatigue severity in joint hypermobility syndrome/Ehlers–Danlos syndrome - hypermobility type. In: Disability and Rehabilitation. 2018 ; Vol. 40, No. 17. pp. 1989-1996.
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Features that exacerbate fatigue severity in joint hypermobility syndrome/Ehlers–Danlos syndrome - hypermobility type. / Krahe, Anne Maree; Adams, Roger David; Nicholson, Leslie Lorenda.

In: Disability and Rehabilitation, Vol. 40, No. 17, 2018, p. 1989-1996.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Features that exacerbate fatigue severity in joint hypermobility syndrome/Ehlers–Danlos syndrome - hypermobility type

AU - Krahe, Anne Maree

AU - Adams, Roger David

AU - Nicholson, Leslie Lorenda

PY - 2018

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AB - Aim: To assess the prevalence, severity and impact of fatigue on individuals with joint hypermobility syndrome (JHS)/Ehlers–Danlos syndrome–hypermobility type (EDS-HT) and establish potential determinants of fatigue severity in this population. Methods: Questionnaires on symptoms and signs related to fatigue, quality of life, mental health, physical activity participation and sleep quality were completed by people with JHS/EDS-HT recruited through two social media sites. Multiple regression analysis was performed to identify predictors of fatigue in this population. Results: Significant fatigue was reported by 79.5% of the 117 participants. Multiple regression analysis identified five predictors of fatigue severity, four being potentially modifiable, accounting for 52.3% of the variance in reported fatigue scores. Predictors of fatigue severity were: the self-perceived extent of joint hypermobility, orthostatic dizziness related to heat and exercise, levels of participation in personal relationships and community, current levels of physical activity and dissatisfaction with the diagnostic process and management options provided for their condition. Conclusion: Fatigue is a significant symptom associated with JHS/EDS-HT. Assessment of individuals with this condition should include measures of fatigue severity to enable targeted management of potentially modifiable factors associated with fatigue severity. Implications for rehabilitation: Fatigue is a significant symptom reported by individuals affected by joint hypermobility syndrome/Ehlers–Danlos syndrome–hypermobility type. Potentially modifiable features that contribute to fatigue severity in this population have been identified. Targeted management of these features may decrease the severity and impact of fatigue in joint hypermobility syndrome/Ehlers–Danlos syndrome–hypermobility type.

KW - Health-related quality of life

KW - hypermobile Ehlers–Danlos syndrome

KW - hypermobility syndrome

KW - mental health

KW - orthostatic intolerance

KW - physical activity

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DO - 10.1080/09638288.2017.1323022

M3 - Article

VL - 40

SP - 1989

EP - 1996

JO - International Disability Studies

JF - International Disability Studies

SN - 0963-8288

IS - 17

ER -