Fish oil for rheumatoid arthritis

A Home Medicine Review initiative

Research output: Contribution to journalArticle

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune condition that affects about 2% of the Australian population. In RA, the overproduction of inflammatory mediators such as tumour necrosis factor, interleukin-1, 6, 8 and cytokines, causes chronic inflammation and pain in joints. There is growing evidence of the benefits of omega-3 long chain polyunsaturated fatty acids found in fish oil in reducing chronic inflammation associated with RA. Fish oil contains eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) that compete with inflammatory precursors [3]. Clinical studies and independent therapeutics guidelines suggest to use at least 2.7g of EPA in addition
8 to DHA present in fish oil per day for the pharmacological management of RA. Human studies have shown that fish oil can significantly reduce inflammatory mediators, although this appears to be most significant at when the dose of EPA+DHA is above ≥2.7g daily suggesting that there is a threshold dose required for the effectiveness of fish oil in reducing inflammation. Fish oil has also been shown to reduce the use of nonsteroidal anti-inflammatory drug (NSAID) consumption and thus the risk of well-known NSAID adverse effects such as gastrointestinal bleeding or exacerbation of heart failure.
Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalAmerican Journal of Therapeutics
DOIs
Publication statusE-pub ahead of print - Feb 2018

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Fish Oils
Rheumatoid Arthritis
Medicine
Eicosapentaenoic Acid
Docosahexaenoic Acids
Inflammation
Anti-Inflammatory Agents
Unsaturated Fatty Acids
Interleukin-1
Chronic Pain
Pharmaceutical Preparations
Interleukin-6
Heart Failure
Tumor Necrosis Factor-alpha
Joints
Pharmacology
Guidelines
Hemorrhage
Cytokines
Population

Cite this

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title = "Fish oil for rheumatoid arthritis: A Home Medicine Review initiative",
abstract = "Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune condition that affects about 2{\%} of the Australian population. In RA, the overproduction of inflammatory mediators such as tumour necrosis factor, interleukin-1, 6, 8 and cytokines, causes chronic inflammation and pain in joints. There is growing evidence of the benefits of omega-3 long chain polyunsaturated fatty acids found in fish oil in reducing chronic inflammation associated with RA. Fish oil contains eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) that compete with inflammatory precursors [3]. Clinical studies and independent therapeutics guidelines suggest to use at least 2.7g of EPA in addition8 to DHA present in fish oil per day for the pharmacological management of RA. Human studies have shown that fish oil can significantly reduce inflammatory mediators, although this appears to be most significant at when the dose of EPA+DHA is above ≥2.7g daily suggesting that there is a threshold dose required for the effectiveness of fish oil in reducing inflammation. Fish oil has also been shown to reduce the use of nonsteroidal anti-inflammatory drug (NSAID) consumption and thus the risk of well-known NSAID adverse effects such as gastrointestinal bleeding or exacerbation of heart failure.",
author = "Sam KOSARI and Mark NAUNTON and Kwang YEE and Nenad NAUMOVSKI and Jackson THOMAS",
year = "2018",
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language = "English",
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AU - NAUNTON, Mark

AU - YEE, Kwang

AU - NAUMOVSKI, Nenad

AU - THOMAS, Jackson

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N2 - Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune condition that affects about 2% of the Australian population. In RA, the overproduction of inflammatory mediators such as tumour necrosis factor, interleukin-1, 6, 8 and cytokines, causes chronic inflammation and pain in joints. There is growing evidence of the benefits of omega-3 long chain polyunsaturated fatty acids found in fish oil in reducing chronic inflammation associated with RA. Fish oil contains eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) that compete with inflammatory precursors [3]. Clinical studies and independent therapeutics guidelines suggest to use at least 2.7g of EPA in addition8 to DHA present in fish oil per day for the pharmacological management of RA. Human studies have shown that fish oil can significantly reduce inflammatory mediators, although this appears to be most significant at when the dose of EPA+DHA is above ≥2.7g daily suggesting that there is a threshold dose required for the effectiveness of fish oil in reducing inflammation. Fish oil has also been shown to reduce the use of nonsteroidal anti-inflammatory drug (NSAID) consumption and thus the risk of well-known NSAID adverse effects such as gastrointestinal bleeding or exacerbation of heart failure.

AB - Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune condition that affects about 2% of the Australian population. In RA, the overproduction of inflammatory mediators such as tumour necrosis factor, interleukin-1, 6, 8 and cytokines, causes chronic inflammation and pain in joints. There is growing evidence of the benefits of omega-3 long chain polyunsaturated fatty acids found in fish oil in reducing chronic inflammation associated with RA. Fish oil contains eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) that compete with inflammatory precursors [3]. Clinical studies and independent therapeutics guidelines suggest to use at least 2.7g of EPA in addition8 to DHA present in fish oil per day for the pharmacological management of RA. Human studies have shown that fish oil can significantly reduce inflammatory mediators, although this appears to be most significant at when the dose of EPA+DHA is above ≥2.7g daily suggesting that there is a threshold dose required for the effectiveness of fish oil in reducing inflammation. Fish oil has also been shown to reduce the use of nonsteroidal anti-inflammatory drug (NSAID) consumption and thus the risk of well-known NSAID adverse effects such as gastrointestinal bleeding or exacerbation of heart failure.

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