Folate nutritional genetics and risk for hypertension in an elderly population sample

Xiaowei Ng, Lyndell Boyd, Lisa Dufficy, Nenad Naumovski, Barbara Blades, Cheryl Travers, Peter Lewis, Jonathon Sturm, Zoë Yates, Maureen Townley-Jones, Paul Roach, Martin Veysey, Mark Lucock

Research output: Contribution to journalArticle

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Abstract

Background/Aims: 118 elderly participants (65-90 years) were assessed for any relationship between folate, related genes and hypertension. Methods: Six B-vitamin-related SNPs were genotyped in 80 normotensive and 38 hypertensive subjects. Results: Of six polymorphisms (677C>T-MTHFR, 1298A>C-MTHFR, 80G>A-RFC, 2756A>G-MS, 66A>G- MSR, 19bpDHFR and 1561C>T-GCPII), only 677C>T-MTHFR was a significant risk for hypertension: OR 1.89; 95% CI 1.07-3.32 (χ2 p = 0.038). Additionally, hypertensive subjects had a significantly lower intake of dietary folate than normotensive individuals (p = 0.0221), although this did not markedly alter blood metabolite levels. Several significant linear associations between dietary folate and related blood metabolites were found in normotensive subjects (p < 0.001 for Hcy, red cell and serum folate) and were as predicted on an a priori basis - generally weaker associations existed in hypertensive subjects (p < 0.05 for serum folate). This was true for data examined collectively or by genotype. Multiple-regression analysis for diastolic or systolic blood pressure showed significant interaction for gender and folate intake (p = 0.014 and 0.019, respectively). In both cases this interaction occurred only in females, with higher folate intake associated with decreased blood pressure. Regressing diastolic blood pressure and 677C>T-MTHFR genotype showed significance (males; p = 0.032) and borderline significance (all subjects). Conclusion: Dietary folate and 677C>T-MTHFR genotype may modify blood pressure.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalJournal of Nutrigenetics and Nutrigenomics
Volume2
Issue number1
DOIs
Publication statusPublished - Feb 2009
Externally publishedYes

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Nutrigenomics
nutrigenomics
Folic Acid
folic acid
hypertension
Hypertension
Population
Genotype
metabolites
sampling
Vitamin B Complex
vitamin B complex
genotype
blood
blood pressure
Single Nucleotide Polymorphism
food intake
genetic polymorphism
Blood Pressure
Genes

Cite this

Ng, Xiaowei ; Boyd, Lyndell ; Dufficy, Lisa ; Naumovski, Nenad ; Blades, Barbara ; Travers, Cheryl ; Lewis, Peter ; Sturm, Jonathon ; Yates, Zoë ; Townley-Jones, Maureen ; Roach, Paul ; Veysey, Martin ; Lucock, Mark. / Folate nutritional genetics and risk for hypertension in an elderly population sample. In: Journal of Nutrigenetics and Nutrigenomics. 2009 ; Vol. 2, No. 1. pp. 1-8.
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title = "Folate nutritional genetics and risk for hypertension in an elderly population sample",
abstract = "Background/Aims: 118 elderly participants (65-90 years) were assessed for any relationship between folate, related genes and hypertension. Methods: Six B-vitamin-related SNPs were genotyped in 80 normotensive and 38 hypertensive subjects. Results: Of six polymorphisms (677C>T-MTHFR, 1298A>C-MTHFR, 80G>A-RFC, 2756A>G-MS, 66A>G- MSR, 19bpDHFR and 1561C>T-GCPII), only 677C>T-MTHFR was a significant risk for hypertension: OR 1.89; 95{\%} CI 1.07-3.32 (χ2 p = 0.038). Additionally, hypertensive subjects had a significantly lower intake of dietary folate than normotensive individuals (p = 0.0221), although this did not markedly alter blood metabolite levels. Several significant linear associations between dietary folate and related blood metabolites were found in normotensive subjects (p < 0.001 for Hcy, red cell and serum folate) and were as predicted on an a priori basis - generally weaker associations existed in hypertensive subjects (p < 0.05 for serum folate). This was true for data examined collectively or by genotype. Multiple-regression analysis for diastolic or systolic blood pressure showed significant interaction for gender and folate intake (p = 0.014 and 0.019, respectively). In both cases this interaction occurred only in females, with higher folate intake associated with decreased blood pressure. Regressing diastolic blood pressure and 677C>T-MTHFR genotype showed significance (males; p = 0.032) and borderline significance (all subjects). Conclusion: Dietary folate and 677C>T-MTHFR genotype may modify blood pressure.",
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year = "2009",
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Ng, X, Boyd, L, Dufficy, L, Naumovski, N, Blades, B, Travers, C, Lewis, P, Sturm, J, Yates, Z, Townley-Jones, M, Roach, P, Veysey, M & Lucock, M 2009, 'Folate nutritional genetics and risk for hypertension in an elderly population sample', Journal of Nutrigenetics and Nutrigenomics, vol. 2, no. 1, pp. 1-8. https://doi.org/10.1159/000160079

Folate nutritional genetics and risk for hypertension in an elderly population sample. / Ng, Xiaowei; Boyd, Lyndell; Dufficy, Lisa; Naumovski, Nenad; Blades, Barbara; Travers, Cheryl; Lewis, Peter; Sturm, Jonathon; Yates, Zoë; Townley-Jones, Maureen; Roach, Paul; Veysey, Martin; Lucock, Mark.

In: Journal of Nutrigenetics and Nutrigenomics, Vol. 2, No. 1, 02.2009, p. 1-8.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Folate nutritional genetics and risk for hypertension in an elderly population sample

AU - Ng, Xiaowei

AU - Boyd, Lyndell

AU - Dufficy, Lisa

AU - Naumovski, Nenad

AU - Blades, Barbara

AU - Travers, Cheryl

AU - Lewis, Peter

AU - Sturm, Jonathon

AU - Yates, Zoë

AU - Townley-Jones, Maureen

AU - Roach, Paul

AU - Veysey, Martin

AU - Lucock, Mark

PY - 2009/2

Y1 - 2009/2

N2 - Background/Aims: 118 elderly participants (65-90 years) were assessed for any relationship between folate, related genes and hypertension. Methods: Six B-vitamin-related SNPs were genotyped in 80 normotensive and 38 hypertensive subjects. Results: Of six polymorphisms (677C>T-MTHFR, 1298A>C-MTHFR, 80G>A-RFC, 2756A>G-MS, 66A>G- MSR, 19bpDHFR and 1561C>T-GCPII), only 677C>T-MTHFR was a significant risk for hypertension: OR 1.89; 95% CI 1.07-3.32 (χ2 p = 0.038). Additionally, hypertensive subjects had a significantly lower intake of dietary folate than normotensive individuals (p = 0.0221), although this did not markedly alter blood metabolite levels. Several significant linear associations between dietary folate and related blood metabolites were found in normotensive subjects (p < 0.001 for Hcy, red cell and serum folate) and were as predicted on an a priori basis - generally weaker associations existed in hypertensive subjects (p < 0.05 for serum folate). This was true for data examined collectively or by genotype. Multiple-regression analysis for diastolic or systolic blood pressure showed significant interaction for gender and folate intake (p = 0.014 and 0.019, respectively). In both cases this interaction occurred only in females, with higher folate intake associated with decreased blood pressure. Regressing diastolic blood pressure and 677C>T-MTHFR genotype showed significance (males; p = 0.032) and borderline significance (all subjects). Conclusion: Dietary folate and 677C>T-MTHFR genotype may modify blood pressure.

AB - Background/Aims: 118 elderly participants (65-90 years) were assessed for any relationship between folate, related genes and hypertension. Methods: Six B-vitamin-related SNPs were genotyped in 80 normotensive and 38 hypertensive subjects. Results: Of six polymorphisms (677C>T-MTHFR, 1298A>C-MTHFR, 80G>A-RFC, 2756A>G-MS, 66A>G- MSR, 19bpDHFR and 1561C>T-GCPII), only 677C>T-MTHFR was a significant risk for hypertension: OR 1.89; 95% CI 1.07-3.32 (χ2 p = 0.038). Additionally, hypertensive subjects had a significantly lower intake of dietary folate than normotensive individuals (p = 0.0221), although this did not markedly alter blood metabolite levels. Several significant linear associations between dietary folate and related blood metabolites were found in normotensive subjects (p < 0.001 for Hcy, red cell and serum folate) and were as predicted on an a priori basis - generally weaker associations existed in hypertensive subjects (p < 0.05 for serum folate). This was true for data examined collectively or by genotype. Multiple-regression analysis for diastolic or systolic blood pressure showed significant interaction for gender and folate intake (p = 0.014 and 0.019, respectively). In both cases this interaction occurred only in females, with higher folate intake associated with decreased blood pressure. Regressing diastolic blood pressure and 677C>T-MTHFR genotype showed significance (males; p = 0.032) and borderline significance (all subjects). Conclusion: Dietary folate and 677C>T-MTHFR genotype may modify blood pressure.

KW - Folate

KW - Homocysteine

KW - Hypertension

KW - MTHFR

KW - Polymorphism

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U2 - 10.1159/000160079

DO - 10.1159/000160079

M3 - Article

VL - 2

SP - 1

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JO - Journal of Nutrigenetics and Nutrigenomics

JF - Journal of Nutrigenetics and Nutrigenomics

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