Background - The plasma thiols, especially homocysteine (HCY), folate and vitamin B12 (VitB12) have been implicated in the aetiology of cognitive impairment, anxiety and depression in the elderly. Objective - The aim of the study was to determine whether there was a relationship between plasma thiols, folate and VitB12 and the prevalence of cognitive impairment, anxiety and depression in a sample of 120 elderly subjects (67 females and 53 males), 65 years old and over, living in a NSW Central Coast retirement village. Design - Cognitive impairment was assessed using the Mini-Mental State Examination (MMSE) test and anxiety and depression using the Hospital Anxiety and Depression Scale (HADS). The plasma thiols HCY, cysteine (CYS), cysteinyl-glycine (CYS-GLY) and glutathione (GSH) were measured by high pressure liquid chromatography (HPLC). Serum folate and VitB12 and red cell folate were measured using automated specific binding assays. Outcomes - The severity of anxiety (Pearson’s r = -0.290, P=0.035) and depression (Pearson’s r = -0.365, P=0.007) was inversely related to the concentration of plasma CYS-GLY in males but not in females. In contrast, anxiety was inversely related to the concentration of serum VitB12 in females (Spearman’s rs = -0.269, P=0.028) but not in males. There was no relationship between the other thiols (including HCY) and folate with anxiety and depression (P>0.05). Cognitive impairment was not related to any of the thiols or vitamins probably because cognitive impairment (MMSE score≤24) was very low in this cohort (3 of the 120 subjects). Conclusions - The observed HCY-independent association of CYS-GLY and VitB12 with anxiety and depression in this cohort is a novel finding which may help shed some light on the development of these disorders in the elderly
|Number of pages||1|
|Journal||Asia Pacific Journal of Clinical Nutrition|
|Publication status||Published - 2005|
Roach, P. D., NAUMOVSKI, N., Dufficy, L., Lucock, M. D., Blades, B., Lewis, P., ... Veysey, M. (2005). Folate, vitamin B12, plasma thiols and cognitive function in an elderly population sample. Asia Pacific Journal of Clinical Nutrition, 14, 49.