Folate, vitamin B12, plasma thiols and cognitive function in an elderly population sample

Paul D. Roach, Nenad NAUMOVSKI, Lisa Dufficy, Mark David Lucock, Barbara Blades, Peter Lewis, Jonathon Sturm, Martin Veysey

Research output: Contribution to journalMeeting Abstract

Abstract

Background - The plasma thiols, especially homocysteine (HCY), folate and vitamin B12 (VitB12) have been implicated in the aetiology of cognitive impairment, anxiety and depression in the elderly. Objective - The aim of the study was to determine whether there was a relationship between plasma thiols, folate and VitB12 and the prevalence of cognitive impairment, anxiety and depression in a sample of 120 elderly subjects (67 females and 53 males), 65 years old and over, living in a NSW Central Coast retirement village. Design - Cognitive impairment was assessed using the Mini-Mental State Examination (MMSE) test and anxiety and depression using the Hospital Anxiety and Depression Scale (HADS). The plasma thiols HCY, cysteine (CYS), cysteinyl-glycine (CYS-GLY) and glutathione (GSH) were measured by high pressure liquid chromatography (HPLC). Serum folate and VitB12 and red cell folate were measured using automated specific binding assays. Outcomes - The severity of anxiety (Pearson’s r = -0.290, P=0.035) and depression (Pearson’s r = -0.365, P=0.007) was inversely related to the concentration of plasma CYS-GLY in males but not in females. In contrast, anxiety was inversely related to the concentration of serum VitB12 in females (Spearman’s rs = -0.269, P=0.028) but not in males. There was no relationship between the other thiols (including HCY) and folate with anxiety and depression (P>0.05). Cognitive impairment was not related to any of the thiols or vitamins probably because cognitive impairment (MMSE score≤24) was very low in this cohort (3 of the 120 subjects). Conclusions - The observed HCY-independent association of CYS-GLY and VitB12 with anxiety and depression in this cohort is a novel finding which may help shed some light on the development of these disorders in the elderly
Original languageEnglish
Pages (from-to)49
Number of pages1
JournalAsia Pacific Journal of Clinical Nutrition
Volume14
Publication statusPublished - 2005
Externally publishedYes

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Vitamin B 12
Folic Acid
Sulfhydryl Compounds
Cognition
Anxiety
Homocysteine
Depression
Population
Cysteine
cysteinylglycine
Retirement
Serum
Vitamins
Glutathione
High Pressure Liquid Chromatography
Cognitive Dysfunction

Cite this

Roach, P. D., NAUMOVSKI, N., Dufficy, L., Lucock, M. D., Blades, B., Lewis, P., ... Veysey, M. (2005). Folate, vitamin B12, plasma thiols and cognitive function in an elderly population sample. Asia Pacific Journal of Clinical Nutrition, 14, 49.
Roach, Paul D. ; NAUMOVSKI, Nenad ; Dufficy, Lisa ; Lucock, Mark David ; Blades, Barbara ; Lewis, Peter ; Sturm, Jonathon ; Veysey, Martin. / Folate, vitamin B12, plasma thiols and cognitive function in an elderly population sample. In: Asia Pacific Journal of Clinical Nutrition. 2005 ; Vol. 14. pp. 49.
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abstract = "Background - The plasma thiols, especially homocysteine (HCY), folate and vitamin B12 (VitB12) have been implicated in the aetiology of cognitive impairment, anxiety and depression in the elderly. Objective - The aim of the study was to determine whether there was a relationship between plasma thiols, folate and VitB12 and the prevalence of cognitive impairment, anxiety and depression in a sample of 120 elderly subjects (67 females and 53 males), 65 years old and over, living in a NSW Central Coast retirement village. Design - Cognitive impairment was assessed using the Mini-Mental State Examination (MMSE) test and anxiety and depression using the Hospital Anxiety and Depression Scale (HADS). The plasma thiols HCY, cysteine (CYS), cysteinyl-glycine (CYS-GLY) and glutathione (GSH) were measured by high pressure liquid chromatography (HPLC). Serum folate and VitB12 and red cell folate were measured using automated specific binding assays. Outcomes - The severity of anxiety (Pearson’s r = -0.290, P=0.035) and depression (Pearson’s r = -0.365, P=0.007) was inversely related to the concentration of plasma CYS-GLY in males but not in females. In contrast, anxiety was inversely related to the concentration of serum VitB12 in females (Spearman’s rs = -0.269, P=0.028) but not in males. There was no relationship between the other thiols (including HCY) and folate with anxiety and depression (P>0.05). Cognitive impairment was not related to any of the thiols or vitamins probably because cognitive impairment (MMSE score≤24) was very low in this cohort (3 of the 120 subjects). Conclusions - The observed HCY-independent association of CYS-GLY and VitB12 with anxiety and depression in this cohort is a novel finding which may help shed some light on the development of these disorders in the elderly",
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Roach, PD, NAUMOVSKI, N, Dufficy, L, Lucock, MD, Blades, B, Lewis, P, Sturm, J & Veysey, M 2005, 'Folate, vitamin B12, plasma thiols and cognitive function in an elderly population sample', Asia Pacific Journal of Clinical Nutrition, vol. 14, pp. 49.

Folate, vitamin B12, plasma thiols and cognitive function in an elderly population sample. / Roach, Paul D.; NAUMOVSKI, Nenad; Dufficy, Lisa; Lucock, Mark David; Blades, Barbara; Lewis, Peter; Sturm, Jonathon; Veysey, Martin.

In: Asia Pacific Journal of Clinical Nutrition, Vol. 14, 2005, p. 49.

Research output: Contribution to journalMeeting Abstract

TY - JOUR

T1 - Folate, vitamin B12, plasma thiols and cognitive function in an elderly population sample

AU - Roach, Paul D.

AU - NAUMOVSKI, Nenad

AU - Dufficy, Lisa

AU - Lucock, Mark David

AU - Blades, Barbara

AU - Lewis, Peter

AU - Sturm, Jonathon

AU - Veysey, Martin

PY - 2005

Y1 - 2005

N2 - Background - The plasma thiols, especially homocysteine (HCY), folate and vitamin B12 (VitB12) have been implicated in the aetiology of cognitive impairment, anxiety and depression in the elderly. Objective - The aim of the study was to determine whether there was a relationship between plasma thiols, folate and VitB12 and the prevalence of cognitive impairment, anxiety and depression in a sample of 120 elderly subjects (67 females and 53 males), 65 years old and over, living in a NSW Central Coast retirement village. Design - Cognitive impairment was assessed using the Mini-Mental State Examination (MMSE) test and anxiety and depression using the Hospital Anxiety and Depression Scale (HADS). The plasma thiols HCY, cysteine (CYS), cysteinyl-glycine (CYS-GLY) and glutathione (GSH) were measured by high pressure liquid chromatography (HPLC). Serum folate and VitB12 and red cell folate were measured using automated specific binding assays. Outcomes - The severity of anxiety (Pearson’s r = -0.290, P=0.035) and depression (Pearson’s r = -0.365, P=0.007) was inversely related to the concentration of plasma CYS-GLY in males but not in females. In contrast, anxiety was inversely related to the concentration of serum VitB12 in females (Spearman’s rs = -0.269, P=0.028) but not in males. There was no relationship between the other thiols (including HCY) and folate with anxiety and depression (P>0.05). Cognitive impairment was not related to any of the thiols or vitamins probably because cognitive impairment (MMSE score≤24) was very low in this cohort (3 of the 120 subjects). Conclusions - The observed HCY-independent association of CYS-GLY and VitB12 with anxiety and depression in this cohort is a novel finding which may help shed some light on the development of these disorders in the elderly

AB - Background - The plasma thiols, especially homocysteine (HCY), folate and vitamin B12 (VitB12) have been implicated in the aetiology of cognitive impairment, anxiety and depression in the elderly. Objective - The aim of the study was to determine whether there was a relationship between plasma thiols, folate and VitB12 and the prevalence of cognitive impairment, anxiety and depression in a sample of 120 elderly subjects (67 females and 53 males), 65 years old and over, living in a NSW Central Coast retirement village. Design - Cognitive impairment was assessed using the Mini-Mental State Examination (MMSE) test and anxiety and depression using the Hospital Anxiety and Depression Scale (HADS). The plasma thiols HCY, cysteine (CYS), cysteinyl-glycine (CYS-GLY) and glutathione (GSH) were measured by high pressure liquid chromatography (HPLC). Serum folate and VitB12 and red cell folate were measured using automated specific binding assays. Outcomes - The severity of anxiety (Pearson’s r = -0.290, P=0.035) and depression (Pearson’s r = -0.365, P=0.007) was inversely related to the concentration of plasma CYS-GLY in males but not in females. In contrast, anxiety was inversely related to the concentration of serum VitB12 in females (Spearman’s rs = -0.269, P=0.028) but not in males. There was no relationship between the other thiols (including HCY) and folate with anxiety and depression (P>0.05). Cognitive impairment was not related to any of the thiols or vitamins probably because cognitive impairment (MMSE score≤24) was very low in this cohort (3 of the 120 subjects). Conclusions - The observed HCY-independent association of CYS-GLY and VitB12 with anxiety and depression in this cohort is a novel finding which may help shed some light on the development of these disorders in the elderly

M3 - Meeting Abstract

VL - 14

SP - 49

JO - Asia Pacific Journal of Clinical Nutrition

JF - Asia Pacific Journal of Clinical Nutrition

SN - 0964-7058

ER -