Forensic characterization of 15 autosomal STRs in four populations from Xinjiang, China, and genetic relationships with neighboring populations

Xiaoni Zhan, Atif Adnan, Yuzhang Zhou, Amjad Khan, Kadirya Kasim, Dennis McNevin

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Abstract

The Xinjiang Uyghur Autonomous Region of China (XUARC) harbors 47 ethnic groups including the Manchu (MCH: 0.11%), Mongols (MGL: 0.81%), Kyrgyz (KGZ: 0.86%) and Uzbek (UZK: 0.066%). To establish DNA databases for these populations, allele frequency distributions for 15 autosomal short tandem repeat (STR) loci were determined using the AmpFlSTR Identifiler PCR amplification kit. There was no evidence of departures from Hardy-Weinberg equilibrium (HWE) in any of the four populations and minimal departure from linkage equilibrium (LE) for a very small number of pairwise combinations of loci. The probabilities of identity for the different populations ranged from 1 in 1.51 × 1017 (MCH) to 1 in 9.94 × 1018 (MGL), the combined powers of discrimination ranged from 0.99999999999999999824 (UZK) to 0.9999999999999999848 (MCH) and the combined probabilities of paternal exclusion ranged from 0.9999979323 (UZK) to 0.9999994839 (MCH). Genetic distances, a phylogenetic tree and principal component analysis (PCA) revealed that the MCH, KGZ and UZK are genetically closer to the Han population of Liaoning and the Mongol population of Mongolia while the MGL are closer to Han, Japanese, Korean, Malaysian, Hong Kong Han and Russians living in China.

Original languageEnglish
Article number4673
Number of pages7
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - 16 Mar 2018

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genetic relationships
China
loci
Mongolia
nationalities and ethnic groups
gene frequency
genetic distance
linkage (genetics)
principal component analysis
forensic sciences
microsatellite repeats
phylogeny
DNA

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Zhan, Xiaoni ; Adnan, Atif ; Zhou, Yuzhang ; Khan, Amjad ; Kasim, Kadirya ; McNevin, Dennis. / Forensic characterization of 15 autosomal STRs in four populations from Xinjiang, China, and genetic relationships with neighboring populations. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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Forensic characterization of 15 autosomal STRs in four populations from Xinjiang, China, and genetic relationships with neighboring populations. / Zhan, Xiaoni; Adnan, Atif; Zhou, Yuzhang; Khan, Amjad; Kasim, Kadirya; McNevin, Dennis.

In: Scientific Reports, Vol. 8, No. 1, 4673, 16.03.2018.

Research output: Contribution to journalArticle

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