Functionalized polymer monoliths with carbamylated amylose for the enantioselective reversed phase nano-liquid chromatographic separation of a set of racemic pharmaceuticals

Ali Fouad, Adel A. Marzouk, Samy M. Ibrahim, Sobhy M. El-Adl, Ashraf Ghanem

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Here we report the first encapsulation of three carbamylated amylose namely R-, S- and R/S-amylose 2,3(3,5-dimethylphenylcarbamate)-6-ethylphenylcarbamate in organic polymer monolith in situ capillary columns. The columns were investigated for the enantioselective nano-liquid chromatographic separation of a set of racemic pharmaceuticals, namely, α- and β-blockers, anti-inflammatory drugs, antifungal drugs, norepinephrine-dopamine reuptake inhibitors, catecholamines, sedative hypnotics, antihistaminics, anticancer drugs, and antiarrhythmic drugs. Baseline separation was achieved for several drugs under reversed phase chromatographic conditions and only few drugs were separated under normal phase conditions. The developed columns provide more economical analysis under environmentally benign conditions.

Original languageEnglish
Pages (from-to)91-99
Number of pages9
JournalJournal of Chromatography A
Volume1515
DOIs
Publication statusPublished - 15 Sep 2017

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Amylose
Polymers
Liquids
Pharmaceutical Preparations
Dopamine Uptake Inhibitors
Organic polymers
Anti-Arrhythmia Agents
Hypnotics and Sedatives
Encapsulation
Catecholamines
Norepinephrine
Anti-Inflammatory Agents

Cite this

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title = "Functionalized polymer monoliths with carbamylated amylose for the enantioselective reversed phase nano-liquid chromatographic separation of a set of racemic pharmaceuticals",
abstract = "Here we report the first encapsulation of three carbamylated amylose namely R-, S- and R/S-amylose 2,3(3,5-dimethylphenylcarbamate)-6-ethylphenylcarbamate in organic polymer monolith in situ capillary columns. The columns were investigated for the enantioselective nano-liquid chromatographic separation of a set of racemic pharmaceuticals, namely, α- and β-blockers, anti-inflammatory drugs, antifungal drugs, norepinephrine-dopamine reuptake inhibitors, catecholamines, sedative hypnotics, antihistaminics, anticancer drugs, and antiarrhythmic drugs. Baseline separation was achieved for several drugs under reversed phase chromatographic conditions and only few drugs were separated under normal phase conditions. The developed columns provide more economical analysis under environmentally benign conditions.",
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Functionalized polymer monoliths with carbamylated amylose for the enantioselective reversed phase nano-liquid chromatographic separation of a set of racemic pharmaceuticals. / Fouad, Ali; Marzouk, Adel A.; Ibrahim, Samy M.; El-Adl, Sobhy M.; Ghanem, Ashraf.

In: Journal of Chromatography A, Vol. 1515, 15.09.2017, p. 91-99.

Research output: Contribution to journalArticle

TY - JOUR

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AU - Fouad, Ali

AU - Marzouk, Adel A.

AU - Ibrahim, Samy M.

AU - El-Adl, Sobhy M.

AU - Ghanem, Ashraf

PY - 2017/9/15

Y1 - 2017/9/15

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AB - Here we report the first encapsulation of three carbamylated amylose namely R-, S- and R/S-amylose 2,3(3,5-dimethylphenylcarbamate)-6-ethylphenylcarbamate in organic polymer monolith in situ capillary columns. The columns were investigated for the enantioselective nano-liquid chromatographic separation of a set of racemic pharmaceuticals, namely, α- and β-blockers, anti-inflammatory drugs, antifungal drugs, norepinephrine-dopamine reuptake inhibitors, catecholamines, sedative hypnotics, antihistaminics, anticancer drugs, and antiarrhythmic drugs. Baseline separation was achieved for several drugs under reversed phase chromatographic conditions and only few drugs were separated under normal phase conditions. The developed columns provide more economical analysis under environmentally benign conditions.

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KW - Capillary

KW - Enantioseparation

KW - Encapsulation

KW - Monolith

KW - Organic polymer

KW - Pharmaceutical Preparations/chemistry

KW - Stereoisomerism

KW - Chromatography, High Pressure Liquid/instrumentation

KW - Chromatography, Reverse-Phase/instrumentation

KW - Amylose/chemistry

KW - Polymers/chemistry

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DO - 10.1016/j.chroma.2017.07.065

M3 - Article

VL - 1515

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JO - Journal of Chromatography

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SN - 0021-9673

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