TY - JOUR
T1 - Functionalized polymer monoliths with carbamylated amylose for the enantioselective reversed phase nano-liquid chromatographic separation of a set of racemic pharmaceuticals
AU - Fouad, Ali
AU - Marzouk, Adel A.
AU - Ibrahim, Samy M.
AU - El-Adl, Sobhy M.
AU - Ghanem, Ashraf
PY - 2017/9/15
Y1 - 2017/9/15
N2 - Here we report the first encapsulation of three carbamylated amylose namely R-, S- and R/S-amylose 2,3(3,5-dimethylphenylcarbamate)-6-ethylphenylcarbamate in organic polymer monolith in situ capillary columns. The columns were investigated for the enantioselective nano-liquid chromatographic separation of a set of racemic pharmaceuticals, namely, α- and β-blockers, anti-inflammatory drugs, antifungal drugs, norepinephrine-dopamine reuptake inhibitors, catecholamines, sedative hypnotics, antihistaminics, anticancer drugs, and antiarrhythmic drugs. Baseline separation was achieved for several drugs under reversed phase chromatographic conditions and only few drugs were separated under normal phase conditions. The developed columns provide more economical analysis under environmentally benign conditions.
AB - Here we report the first encapsulation of three carbamylated amylose namely R-, S- and R/S-amylose 2,3(3,5-dimethylphenylcarbamate)-6-ethylphenylcarbamate in organic polymer monolith in situ capillary columns. The columns were investigated for the enantioselective nano-liquid chromatographic separation of a set of racemic pharmaceuticals, namely, α- and β-blockers, anti-inflammatory drugs, antifungal drugs, norepinephrine-dopamine reuptake inhibitors, catecholamines, sedative hypnotics, antihistaminics, anticancer drugs, and antiarrhythmic drugs. Baseline separation was achieved for several drugs under reversed phase chromatographic conditions and only few drugs were separated under normal phase conditions. The developed columns provide more economical analysis under environmentally benign conditions.
KW - Amylose
KW - Capillary
KW - Enantioseparation
KW - Encapsulation
KW - Monolith
KW - Organic polymer
KW - Pharmaceutical Preparations/chemistry
KW - Stereoisomerism
KW - Chromatography, High Pressure Liquid/instrumentation
KW - Chromatography, Reverse-Phase/instrumentation
KW - Amylose/chemistry
KW - Polymers/chemistry
UR - http://www.scopus.com/inward/record.url?scp=85026887187&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/functionalized-polymer-monoliths-carbamylated-amylose-enantioselective-reversed-phase-nanoliquid-chr
U2 - 10.1016/j.chroma.2017.07.065
DO - 10.1016/j.chroma.2017.07.065
M3 - Article
C2 - 28797665
AN - SCOPUS:85026887187
SN - 1873-3778
VL - 1515
SP - 91
EP - 99
JO - Journal of Chromatography A
JF - Journal of Chromatography A
ER -