Functionalized polymer monoliths with carbamylated amylose for the enantioselective reversed phase nano-liquid chromatographic separation of a set of racemic pharmaceuticals

Ali Fouad, Adel A. Marzouk, Samy M. Ibrahim, Sobhy M. El-Adl, Ashraf Ghanem

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Here we report the first encapsulation of three carbamylated amylose namely R-, S- and R/S-amylose 2,3(3,5-dimethylphenylcarbamate)-6-ethylphenylcarbamate in organic polymer monolith in situ capillary columns. The columns were investigated for the enantioselective nano-liquid chromatographic separation of a set of racemic pharmaceuticals, namely, α- and β-blockers, anti-inflammatory drugs, antifungal drugs, norepinephrine-dopamine reuptake inhibitors, catecholamines, sedative hypnotics, antihistaminics, anticancer drugs, and antiarrhythmic drugs. Baseline separation was achieved for several drugs under reversed phase chromatographic conditions and only few drugs were separated under normal phase conditions. The developed columns provide more economical analysis under environmentally benign conditions.

Original languageEnglish
Pages (from-to)91-99
Number of pages9
JournalJournal of Chromatography A
Volume1515
DOIs
Publication statusPublished - 15 Sep 2017

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