TY - JOUR
T1 - Gastrointestinal mucositis
T2 - The role of MMP-tight junction interactions in tissue injury
AU - Al-Dasooqi, Noor
AU - Wardill, Hannah R.
AU - Gibson, Rachel J.
PY - 2014/7
Y1 - 2014/7
N2 - Chemotherapy for cancer causes significant gut toxicity known as mucositis. The pathogenesis of mucositis is ill defined. Recent clinical research guidelines have highlighted epithelial junctional complexes as emerging targets within mucositis research. Given the robust biological evidence linking tight junctions and matrix metalloproteinases, key mediators of mucositis, tight junction proteins have received significant attention. Despite this, the link between tight junctions, matrix metalloproteinases and mucositis development is yet to be established. This critical review therefore aims to describe the role of matrix metalloproteinases in mucositis, and how matrix metalloproteinase- dependent tight junction disruption may contribute to the pathobiology of mucositis.
AB - Chemotherapy for cancer causes significant gut toxicity known as mucositis. The pathogenesis of mucositis is ill defined. Recent clinical research guidelines have highlighted epithelial junctional complexes as emerging targets within mucositis research. Given the robust biological evidence linking tight junctions and matrix metalloproteinases, key mediators of mucositis, tight junction proteins have received significant attention. Despite this, the link between tight junctions, matrix metalloproteinases and mucositis development is yet to be established. This critical review therefore aims to describe the role of matrix metalloproteinases in mucositis, and how matrix metalloproteinase- dependent tight junction disruption may contribute to the pathobiology of mucositis.
KW - Gut toxicity, Mucositis, Chemotherapy
KW - Matrix metalloproteinases
KW - Tight junctions
UR - http://www.scopus.com/inward/record.url?scp=84904110854&partnerID=8YFLogxK
U2 - 10.1007/s12253-013-9733-y
DO - 10.1007/s12253-013-9733-y
M3 - Review article
C2 - 24424533
AN - SCOPUS:84904110854
SN - 1219-4956
VL - 20
SP - 485
EP - 491
JO - Pathology and Oncology Research
JF - Pathology and Oncology Research
IS - 3
ER -
