Gender-specific, lifestyle-related factors and 10-year cardiovascular disease risk; the ATTICA and GREECS cohort studies

Matina Kouvari, Demosthenes B. Panagiotakos, Christina Chrysohoou, Ekavi Georgousopoulou, Venetia Notara, Dimitrios Tousoulis, Christos Pitsavos

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Lifestyle remains a huge driving force of Cardiovascular Diseases (CVD) on-set/progression. Lifestyle-patterns are highly dependent on gender-related attitudes. Objective: To evaluate the gender-specific association of lifestyle-related factors (adherence to Mediterranean diet (MedDiet), Physical Activity (PA), smoking) with 10-year first and recurrent CVD events. Methods: Two prospective studies, the ATTICA (2002-2012, n=3,042 subjects free-of-CVD) and GREECS (2004-2014, n=2,172 subjects with Acute Coronary Syndrome (ACS)) were undertaken. Baseline adherence to MedDiet (MedDietScore <27/≥27, range 0-55), PA (sedentary/physically active) and smoking (current/never) was tested against 10-year first (ATTICA) and recurrent (GREECS) CVD events, in men and women. Results: The “superiority” of men over women regarding overall CVD events was revealed in both first (ATTICA, 19.7% men vs. 11.7% women, p<0.001) and recurrent CVD events, but less significantly (GREECS, 38.8% men vs. 32.9% women, p=0.016). Gender-stratified analysis revealed that: lower adherence to MedDiet in women (Odds Ratio (OR)=1.22, 95% Confidence Interval (95%CI) 1.03, 1.51) and PA (OR=1.35, 95%CI 1.01, 1.85) and smoking (OR=1.28, 95%CI 1.04, 1.82) in men, were independent predictors of 10-year first CVD event; whereas, adherence to MedDiet (OR=1.28, 95%CI 1.01, 1.59), PA (OR=1.25, 95%CI 1.01, 2.50) and smoking (OR=1.15, 95%CI 1.01, 1.30) in women, yet only adherence to MedDiet (OR=1.27, 95%CI 1.01, 1.35) and PA (OR=1.27, 95%CI 1.02, 1.59) in men, were independent predictors of 10-year CVD recurrent events. Conclusion: Differences between men and women, in the effect-size measures of lifestyle-related factors, underline different paths for men and women, probably contributing to better designing strategies for primary and secondary CVD prevention.

Original languageEnglish
Pages (from-to)401-410
Number of pages10
JournalCurrent Vascular Pharmacology
Volume17
Issue number4
DOIs
Publication statusPublished - 2019

Fingerprint

Life Style
Cohort Studies
Cardiovascular Diseases
Mediterranean Diet
Odds Ratio
Confidence Intervals
Smoking
Exercise
Acute Coronary Syndrome
Prospective Studies

Cite this

Kouvari, M., Panagiotakos, D. B., Chrysohoou, C., Georgousopoulou, E., Notara, V., Tousoulis, D., & Pitsavos, C. (2019). Gender-specific, lifestyle-related factors and 10-year cardiovascular disease risk; the ATTICA and GREECS cohort studies. Current Vascular Pharmacology, 17(4), 401-410. https://doi.org/10.2174/1570161116666180608121720
Kouvari, Matina ; Panagiotakos, Demosthenes B. ; Chrysohoou, Christina ; Georgousopoulou, Ekavi ; Notara, Venetia ; Tousoulis, Dimitrios ; Pitsavos, Christos. / Gender-specific, lifestyle-related factors and 10-year cardiovascular disease risk; the ATTICA and GREECS cohort studies. In: Current Vascular Pharmacology. 2019 ; Vol. 17, No. 4. pp. 401-410.
@article{1c5f3b8bbfcb45bf9efa9233aed54a4b,
title = "Gender-specific, lifestyle-related factors and 10-year cardiovascular disease risk; the ATTICA and GREECS cohort studies",
abstract = "Background: Lifestyle remains a huge driving force of Cardiovascular Diseases (CVD) on-set/progression. Lifestyle-patterns are highly dependent on gender-related attitudes. Objective: To evaluate the gender-specific association of lifestyle-related factors (adherence to Mediterranean diet (MedDiet), Physical Activity (PA), smoking) with 10-year first and recurrent CVD events. Methods: Two prospective studies, the ATTICA (2002-2012, n=3,042 subjects free-of-CVD) and GREECS (2004-2014, n=2,172 subjects with Acute Coronary Syndrome (ACS)) were undertaken. Baseline adherence to MedDiet (MedDietScore <27/≥27, range 0-55), PA (sedentary/physically active) and smoking (current/never) was tested against 10-year first (ATTICA) and recurrent (GREECS) CVD events, in men and women. Results: The “superiority” of men over women regarding overall CVD events was revealed in both first (ATTICA, 19.7{\%} men vs. 11.7{\%} women, p<0.001) and recurrent CVD events, but less significantly (GREECS, 38.8{\%} men vs. 32.9{\%} women, p=0.016). Gender-stratified analysis revealed that: lower adherence to MedDiet in women (Odds Ratio (OR)=1.22, 95{\%} Confidence Interval (95{\%}CI) 1.03, 1.51) and PA (OR=1.35, 95{\%}CI 1.01, 1.85) and smoking (OR=1.28, 95{\%}CI 1.04, 1.82) in men, were independent predictors of 10-year first CVD event; whereas, adherence to MedDiet (OR=1.28, 95{\%}CI 1.01, 1.59), PA (OR=1.25, 95{\%}CI 1.01, 2.50) and smoking (OR=1.15, 95{\%}CI 1.01, 1.30) in women, yet only adherence to MedDiet (OR=1.27, 95{\%}CI 1.01, 1.35) and PA (OR=1.27, 95{\%}CI 1.02, 1.59) in men, were independent predictors of 10-year CVD recurrent events. Conclusion: Differences between men and women, in the effect-size measures of lifestyle-related factors, underline different paths for men and women, probably contributing to better designing strategies for primary and secondary CVD prevention.",
keywords = "Cardiovascular diseases, Gender, Lifestyle, Primary prevention, Secondary prevention, Sex",
author = "Matina Kouvari and Panagiotakos, {Demosthenes B.} and Christina Chrysohoou and Ekavi Georgousopoulou and Venetia Notara and Dimitrios Tousoulis and Christos Pitsavos",
year = "2019",
doi = "10.2174/1570161116666180608121720",
language = "English",
volume = "17",
pages = "401--410",
journal = "Current Vascular Pharmacology",
issn = "1570-1611",
publisher = "Bentham Science Publishers B.V.",
number = "4",

}

Kouvari, M, Panagiotakos, DB, Chrysohoou, C, Georgousopoulou, E, Notara, V, Tousoulis, D & Pitsavos, C 2019, 'Gender-specific, lifestyle-related factors and 10-year cardiovascular disease risk; the ATTICA and GREECS cohort studies', Current Vascular Pharmacology, vol. 17, no. 4, pp. 401-410. https://doi.org/10.2174/1570161116666180608121720

Gender-specific, lifestyle-related factors and 10-year cardiovascular disease risk; the ATTICA and GREECS cohort studies. / Kouvari, Matina; Panagiotakos, Demosthenes B.; Chrysohoou, Christina; Georgousopoulou, Ekavi; Notara, Venetia; Tousoulis, Dimitrios; Pitsavos, Christos.

In: Current Vascular Pharmacology, Vol. 17, No. 4, 2019, p. 401-410.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Gender-specific, lifestyle-related factors and 10-year cardiovascular disease risk; the ATTICA and GREECS cohort studies

AU - Kouvari, Matina

AU - Panagiotakos, Demosthenes B.

AU - Chrysohoou, Christina

AU - Georgousopoulou, Ekavi

AU - Notara, Venetia

AU - Tousoulis, Dimitrios

AU - Pitsavos, Christos

PY - 2019

Y1 - 2019

N2 - Background: Lifestyle remains a huge driving force of Cardiovascular Diseases (CVD) on-set/progression. Lifestyle-patterns are highly dependent on gender-related attitudes. Objective: To evaluate the gender-specific association of lifestyle-related factors (adherence to Mediterranean diet (MedDiet), Physical Activity (PA), smoking) with 10-year first and recurrent CVD events. Methods: Two prospective studies, the ATTICA (2002-2012, n=3,042 subjects free-of-CVD) and GREECS (2004-2014, n=2,172 subjects with Acute Coronary Syndrome (ACS)) were undertaken. Baseline adherence to MedDiet (MedDietScore <27/≥27, range 0-55), PA (sedentary/physically active) and smoking (current/never) was tested against 10-year first (ATTICA) and recurrent (GREECS) CVD events, in men and women. Results: The “superiority” of men over women regarding overall CVD events was revealed in both first (ATTICA, 19.7% men vs. 11.7% women, p<0.001) and recurrent CVD events, but less significantly (GREECS, 38.8% men vs. 32.9% women, p=0.016). Gender-stratified analysis revealed that: lower adherence to MedDiet in women (Odds Ratio (OR)=1.22, 95% Confidence Interval (95%CI) 1.03, 1.51) and PA (OR=1.35, 95%CI 1.01, 1.85) and smoking (OR=1.28, 95%CI 1.04, 1.82) in men, were independent predictors of 10-year first CVD event; whereas, adherence to MedDiet (OR=1.28, 95%CI 1.01, 1.59), PA (OR=1.25, 95%CI 1.01, 2.50) and smoking (OR=1.15, 95%CI 1.01, 1.30) in women, yet only adherence to MedDiet (OR=1.27, 95%CI 1.01, 1.35) and PA (OR=1.27, 95%CI 1.02, 1.59) in men, were independent predictors of 10-year CVD recurrent events. Conclusion: Differences between men and women, in the effect-size measures of lifestyle-related factors, underline different paths for men and women, probably contributing to better designing strategies for primary and secondary CVD prevention.

AB - Background: Lifestyle remains a huge driving force of Cardiovascular Diseases (CVD) on-set/progression. Lifestyle-patterns are highly dependent on gender-related attitudes. Objective: To evaluate the gender-specific association of lifestyle-related factors (adherence to Mediterranean diet (MedDiet), Physical Activity (PA), smoking) with 10-year first and recurrent CVD events. Methods: Two prospective studies, the ATTICA (2002-2012, n=3,042 subjects free-of-CVD) and GREECS (2004-2014, n=2,172 subjects with Acute Coronary Syndrome (ACS)) were undertaken. Baseline adherence to MedDiet (MedDietScore <27/≥27, range 0-55), PA (sedentary/physically active) and smoking (current/never) was tested against 10-year first (ATTICA) and recurrent (GREECS) CVD events, in men and women. Results: The “superiority” of men over women regarding overall CVD events was revealed in both first (ATTICA, 19.7% men vs. 11.7% women, p<0.001) and recurrent CVD events, but less significantly (GREECS, 38.8% men vs. 32.9% women, p=0.016). Gender-stratified analysis revealed that: lower adherence to MedDiet in women (Odds Ratio (OR)=1.22, 95% Confidence Interval (95%CI) 1.03, 1.51) and PA (OR=1.35, 95%CI 1.01, 1.85) and smoking (OR=1.28, 95%CI 1.04, 1.82) in men, were independent predictors of 10-year first CVD event; whereas, adherence to MedDiet (OR=1.28, 95%CI 1.01, 1.59), PA (OR=1.25, 95%CI 1.01, 2.50) and smoking (OR=1.15, 95%CI 1.01, 1.30) in women, yet only adherence to MedDiet (OR=1.27, 95%CI 1.01, 1.35) and PA (OR=1.27, 95%CI 1.02, 1.59) in men, were independent predictors of 10-year CVD recurrent events. Conclusion: Differences between men and women, in the effect-size measures of lifestyle-related factors, underline different paths for men and women, probably contributing to better designing strategies for primary and secondary CVD prevention.

KW - Cardiovascular diseases

KW - Gender

KW - Lifestyle

KW - Primary prevention

KW - Secondary prevention

KW - Sex

UR - http://www.scopus.com/inward/record.url?scp=85060237368&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/genderspecific-lifestylerelated-factors-10year-cardiovascular-disease-risk-attica-greecs-cohort-stud

U2 - 10.2174/1570161116666180608121720

DO - 10.2174/1570161116666180608121720

M3 - Article

VL - 17

SP - 401

EP - 410

JO - Current Vascular Pharmacology

JF - Current Vascular Pharmacology

SN - 1570-1611

IS - 4

ER -