Genome-wide SNP analysis of Siamese cobra (Naja kaouthia) reveals the molecular basis of transitions between Z and W sex chromosomes and supports the presence of an ancestral super-sex chromosome in amniotes

Nararat Laopichienpong, Ekaphan Kraichak, Worapong Singchat, Siwapech Sillapaprayoon, Narongrit Muangmai, Sunutcha Suntrarachun, Sudarath Baicharoen, Surin Peyachoknagul, Lawan Chanhome, Tariq Ezaz, Kornsorn Srikulnath

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Elucidation of the process of sex chromosome differentiation is necessary to understand the dynamics of evolutionary mechanisms in organisms. The W sex chromosome of the Siamese cobra (Naja kaouthia) contains a large number of repeats and shares amniote sex chromosomal linkages. Diversity Arrays Technology provides an effective approach to identify sex-specific loci that are epoch-making, to understand the dynamics of molecular transitions between the Z and W sex chromosomes in a snake lineage. From a total of 543 sex-specific loci, 90 showed partial homology with sex chromosomes of several amniotes and 89 loci were homologous to transposable elements. Two loci were confirmed as W-specific nucleotides after PCR amplification. These loci might result from a sex chromosome differentiation process and involve putative sex-determination regions in the Siamese cobra. Sex-specific loci shared linkage homologies among amniote sex chromosomes, supporting an ancestral super-sex chromosome.

Original languageEnglish
Pages (from-to)624-636
Number of pages13
JournalGenomics
Volume113
Issue number1P2
DOIs
Publication statusPublished - Jan 2021

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