Genomic Approaches to the Host Response to Pathogens

Frances SHANNON

    Research output: A Conference proceeding or a Chapter in BookChapter

    1 Citation (Scopus)

    Abstract

    The need to better understand host-pathogen interactions has risen with the expansion in genomics and related technologies. This chapter focuses on two aspects of the host response to pathogens where major advances are being made using genomic approaches. The availability of complete genomic sequences of an expanding number of pathogens, the human and mouse genome sequences, and the advent of genome-wide genotyping and gene expression profiling has opened up new avenues of investigation in the field. The genotype of the pathogen plays a major role in the response of the host to infection with more virulent pathogenic strains possessing the capability to interfere with the host immune response. In addition, different individuals in a population can have very different responses to a genetically identical pathogen. Part of the differential response is governed by the underlying genetic differences between individuals. The advent of genome-wide genotyping using single nucleotide polymorphisms or microsatellite markers is leading to major advances in molecular epidemiology. The future impact of genomic approaches on the development of diagnostics and therapeutics is discussed for infectious diseases. This includes defining the basis of genetic susceptibility to infection and system-wide molecular response to a pathogen. © 2010

    Original languageEnglish
    Title of host publicationEssentials of Genomic and Personalized Medicine
    PublisherElsevier Inc.
    Chapter57
    Pages733-743
    Number of pages11
    ISBN (Print)9780123749345
    DOIs
    Publication statusPublished - 1 Dec 2010

    Fingerprint

    Pathogens
    Genome
    Host-Pathogen Interactions
    Molecular Epidemiology
    Gene Expression Profiling
    Human Genome
    Genetic Predisposition to Disease
    Genomics
    Infection
    Individuality
    Microsatellite Repeats
    Single Nucleotide Polymorphism
    Communicable Diseases
    Genes
    Genotype
    Technology
    Population
    Polymorphism
    Gene expression
    Therapeutics

    Cite this

    SHANNON, F. (2010). Genomic Approaches to the Host Response to Pathogens. In Essentials of Genomic and Personalized Medicine (pp. 733-743). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374934-5.00057-X
    SHANNON, Frances. / Genomic Approaches to the Host Response to Pathogens. Essentials of Genomic and Personalized Medicine. Elsevier Inc., 2010. pp. 733-743
    @inbook{296d4d8ed207480f81d2886cd9fbee0d,
    title = "Genomic Approaches to the Host Response to Pathogens",
    abstract = "The need to better understand host-pathogen interactions has risen with the expansion in genomics and related technologies. This chapter focuses on two aspects of the host response to pathogens where major advances are being made using genomic approaches. The availability of complete genomic sequences of an expanding number of pathogens, the human and mouse genome sequences, and the advent of genome-wide genotyping and gene expression profiling has opened up new avenues of investigation in the field. The genotype of the pathogen plays a major role in the response of the host to infection with more virulent pathogenic strains possessing the capability to interfere with the host immune response. In addition, different individuals in a population can have very different responses to a genetically identical pathogen. Part of the differential response is governed by the underlying genetic differences between individuals. The advent of genome-wide genotyping using single nucleotide polymorphisms or microsatellite markers is leading to major advances in molecular epidemiology. The future impact of genomic approaches on the development of diagnostics and therapeutics is discussed for infectious diseases. This includes defining the basis of genetic susceptibility to infection and system-wide molecular response to a pathogen. {\circledC} 2010",
    author = "Frances SHANNON",
    year = "2010",
    month = "12",
    day = "1",
    doi = "10.1016/B978-0-12-374934-5.00057-X",
    language = "English",
    isbn = "9780123749345",
    pages = "733--743",
    booktitle = "Essentials of Genomic and Personalized Medicine",
    publisher = "Elsevier Inc.",
    address = "United States",

    }

    SHANNON, F 2010, Genomic Approaches to the Host Response to Pathogens. in Essentials of Genomic and Personalized Medicine. Elsevier Inc., pp. 733-743. https://doi.org/10.1016/B978-0-12-374934-5.00057-X

    Genomic Approaches to the Host Response to Pathogens. / SHANNON, Frances.

    Essentials of Genomic and Personalized Medicine. Elsevier Inc., 2010. p. 733-743.

    Research output: A Conference proceeding or a Chapter in BookChapter

    TY - CHAP

    T1 - Genomic Approaches to the Host Response to Pathogens

    AU - SHANNON, Frances

    PY - 2010/12/1

    Y1 - 2010/12/1

    N2 - The need to better understand host-pathogen interactions has risen with the expansion in genomics and related technologies. This chapter focuses on two aspects of the host response to pathogens where major advances are being made using genomic approaches. The availability of complete genomic sequences of an expanding number of pathogens, the human and mouse genome sequences, and the advent of genome-wide genotyping and gene expression profiling has opened up new avenues of investigation in the field. The genotype of the pathogen plays a major role in the response of the host to infection with more virulent pathogenic strains possessing the capability to interfere with the host immune response. In addition, different individuals in a population can have very different responses to a genetically identical pathogen. Part of the differential response is governed by the underlying genetic differences between individuals. The advent of genome-wide genotyping using single nucleotide polymorphisms or microsatellite markers is leading to major advances in molecular epidemiology. The future impact of genomic approaches on the development of diagnostics and therapeutics is discussed for infectious diseases. This includes defining the basis of genetic susceptibility to infection and system-wide molecular response to a pathogen. © 2010

    AB - The need to better understand host-pathogen interactions has risen with the expansion in genomics and related technologies. This chapter focuses on two aspects of the host response to pathogens where major advances are being made using genomic approaches. The availability of complete genomic sequences of an expanding number of pathogens, the human and mouse genome sequences, and the advent of genome-wide genotyping and gene expression profiling has opened up new avenues of investigation in the field. The genotype of the pathogen plays a major role in the response of the host to infection with more virulent pathogenic strains possessing the capability to interfere with the host immune response. In addition, different individuals in a population can have very different responses to a genetically identical pathogen. Part of the differential response is governed by the underlying genetic differences between individuals. The advent of genome-wide genotyping using single nucleotide polymorphisms or microsatellite markers is leading to major advances in molecular epidemiology. The future impact of genomic approaches on the development of diagnostics and therapeutics is discussed for infectious diseases. This includes defining the basis of genetic susceptibility to infection and system-wide molecular response to a pathogen. © 2010

    UR - http://www.scopus.com/inward/record.url?scp=83455227668&partnerID=8YFLogxK

    U2 - 10.1016/B978-0-12-374934-5.00057-X

    DO - 10.1016/B978-0-12-374934-5.00057-X

    M3 - Chapter

    SN - 9780123749345

    SP - 733

    EP - 743

    BT - Essentials of Genomic and Personalized Medicine

    PB - Elsevier Inc.

    ER -

    SHANNON F. Genomic Approaches to the Host Response to Pathogens. In Essentials of Genomic and Personalized Medicine. Elsevier Inc. 2010. p. 733-743 https://doi.org/10.1016/B978-0-12-374934-5.00057-X