Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017

a systematic analysis for the Global Burden of Disease Study 2017

GBD 2017 Disease and Injury Incidence and Prevalence Collaborators, Narges Karimi, Seyed M Karimi, Amir Kasaeian, Dessalegn H Kassa, Getachew Mullu Kassa, Tesfaye Dessale Kassa, Nicholas Kassebaum, Srinivasa V Katikireddi, Norito kawakami, Ali Kazemi Karyani, Masoud M. Keighobadi, Peter Njenga Keiyoro, Laura Kemmer, Grant R. Kemp, Andre P Kengne, Andre Keren, Yousef Khader, Behzad Khafaei, Morteza Abdullatif Khafaie & 110 others Alireza Khajavi, Ibrahim Khalil, E. A. Khan, Muhammad Shahzeb Khan, Muhammad Ali Khan, Young-Ho Khang, Zahra Khazaeipour, Abdullah T Khoja, A. Khosravi, Mohammad Hossein Khosravi, Aliasghar Ahmad Kiadaliri, Daniel N. Kiirithio, Cho-Il Kim, Daniel Kim, Pauline Kim, Young-Eun Kim, Yun J Kim, Ruth Kimokoti, Yohannes KINFU, Adnan Kisa, Katarzyna Kissimova-Skarbek, Mika Kivimäki, Ann K. S. Knudsen, Jonathan M Kocarnik, Sonali Kochhar, Yoshihiro Kokubo, Tufa Kolola, Jacek A Kopec, Soewarta Kosen, Georgios A. Kotsakis, P. A. Koul, A. Koyanagi, Michael A Kravchenko, Kewal Krishan, Kristopher J. Krohn, Barthelemy Kuate Defo, B. Kucuk Bicer, G Kumar, Manasi Kumar, Hmwehmwe Kyu, Deepesh P Lad, Sheetal D Lad, Alessandra Lafranconi, Ratilal Lalloo, Tea Lallukka, Faris Hasan Al Lami, Van C Lansingh, Arman Latifi,, Kathryn Mei-Ming Lau, Jeffrey V Lazarus, Janet Leasher, Jorge R Ledesma, Paul H Lee, James Leigh, Janni Leung, Miriam Levi, Sonia Lewycka, Shanshan Li, Yichong Li, Yu Liao, Misgan Legesse Liben, Lee-Ling Lim, Stephen Lim, Shiwei Liu, Rakesh Lodha, Katharine Looker, Alan Lopez, Stefan Lorkowski, Paulo Lotufo, Nicola Low, Rafael Lozano, Timothy Lucas, Lydia R Lucchesi, Raimundas Lunevicius, Ronan Lyons, Stefan Ma, Erlyn Rachelle King Macarayan, Mark T Mackay, Fabiana Madotto, H. Magdy Abd El Razek, Mohamed Magdy Abd El Razek, Dhaval P Maghavani, Narayan Bahadur Mahotra, Hue Thi Mai, Marek Majdan, Reza Majdzadeh, Azeem Majeed, Reza Malekzadeh, Deborah C Malta, Abdullah A Mamun, Ana-Laura Manda, Helena Manguerra, Treh Manhertz, Mohammad A. Mansournia, Lorenzo G. Mantovani, Christopher Mapoma, Joemer C Maravilla, wagner MArcenes, Ashley Marks, Francisco Rogerlândio Martins-Melo, Ira Martopullo, Winfried März, M. B. Marzan, Tivani Phosa Mashamba-Thompson, Benjamin Ballard Massenburg, Manu Raj Mathur, Kunihiro Matsushita, Pallab K Maulik, Mohsen Mazidi, Colm McAlinden

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Abstract

Background: The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) includes a comprehensive assessment of incidence, prevalence, and years lived with disability (YLDs) for 354 causes in 195 countries and territories from 1990 to 2017. Previous GBD studies have shown how the decline of mortality rates from 1990 to 2016 has led to an increase in life expectancy, an ageing global population, and an expansion of the non-fatal burden of disease and injury. These studies have also shown how a substantial portion of the world's population experiences non-fatal health loss with considerable heterogeneity among different causes, locations, ages, and sexes. Ongoing objectives of the GBD study include increasing the level of estimation detail, improving analytical strategies, and increasing the amount of high-quality data. Methods: We estimated incidence and prevalence for 354 diseases and injuries and 3484 sequelae. We used an updated and extensive body of literature studies, survey data, surveillance data, inpatient admission records, outpatient visit records, and health insurance claims, and additionally used results from cause of death models to inform estimates using a total of 68 781 data sources. Newly available clinical data from India, Iran, Japan, Jordan, Nepal, China, Brazil, Norway, and Italy were incorporated, as well as updated claims data from the USA and new claims data from Taiwan (province of China) and Singapore. We used DisMod-MR 2.1, a Bayesian meta-regression tool, as the main method of estimation, ensuring consistency between rates of incidence, prevalence, remission, and cause of death for each condition. YLDs were estimated as the product of a prevalence estimate and a disability weight for health states of each mutually exclusive sequela, adjusted for comorbidity. We updated the Socio-demographic Index (SDI), a summary development indicator of income per capita, years of schooling, and total fertility rate. Additionally, we calculated differences between male and female YLDs to identify divergent trends across sexes. GBD 2017 complies with the Guidelines for Accurate and Transparent Health Estimates Reporting. Findings: Globally, for females, the causes with the greatest age-standardised prevalence were oral disorders, headache disorders, and haemoglobinopathies and haemolytic anaemias in both 1990 and 2017. For males, the causes with the greatest age-standardised prevalence were oral disorders, headache disorders, and tuberculosis including latent tuberculosis infection in both 1990 and 2017. In terms of YLDs, low back pain, headache disorders, and dietary iron deficiency were the leading Level 3 causes of YLD counts in 1990, whereas low back pain, headache disorders, and depressive disorders were the leading causes in 2017 for both sexes combined. All-cause age-standardised YLD rates decreased by 3·9% (95% uncertainty interval [UI] 3·1–4·6) from 1990 to 2017; however, the all-age YLD rate increased by 7·2% (6·0–8·4) while the total sum of global YLDs increased from 562 million (421–723) to 853 million (642–1100). The increases for males and females were similar, with increases in all-age YLD rates of 7·9% (6·6–9·2) for males and 6·5% (5·4–7·7) for females. We found significant differences between males and females in terms of age-standardised prevalence estimates for multiple causes. The causes with the greatest relative differences between sexes in 2017 included substance use disorders (3018 cases [95% UI 2782–3252] per 100 000 in males vs s1400 [1279–1524] per 100 000 in females), transport injuries (3322 [3082–3583] vs 2336 [2154–2535]), and self-harm and interpersonal violence (3265 [2943–3630] vs 5643 [5057–6302]). Interpretation: Global all-cause age-standardised YLD rates have improved only slightly over a period spanning nearly three decades. However, the magnitude of the non-fatal disease burden has expanded globally, with increasing numbers of people who have a wide spectrum of conditions. A subset of conditions has remained globally pervasive since 1990, whereas other conditions have displayed more dynamic trends, with different ages, sexes, and geographies across the globe experiencing varying burdens and trends of health loss. This study emphasises how global improvements in premature mortality for select conditions have led to older populations with complex and potentially expensive diseases, yet also highlights global achievements in certain domains of disease and injury. Funding: Bill & Melinda Gates Foundation.

Original languageEnglish
Pages (from-to)1789-1858
Number of pages70
JournalThe Lancet
Volume392
Issue number10159
DOIs
Publication statusPublished - 10 Nov 2018

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Headache Disorders
Incidence
Wounds and Injuries
Somatoform Disorders
Health
Low Back Pain
Uncertainty
Cause of Death
China
Dietary Iron
Population
Latent Tuberculosis
Hemoglobinopathies
Jordan
Nepal
Geography
Premature Mortality
Birth Rate
Information Storage and Retrieval
Hemolytic Anemia

Cite this

GBD 2017 Disease and Injury Incidence and Prevalence Collaborators, Karimi, N., Karimi, S. M., Kasaeian, A., Kassa, D. H., Kassa, G. M., ... McAlinden, C. (2018). Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet, 392(10159), 1789-1858. https://doi.org/10.1016/S0140-6736(18)32279-7
GBD 2017 Disease and Injury Incidence and Prevalence Collaborators ; Karimi, Narges ; Karimi, Seyed M ; Kasaeian, Amir ; Kassa, Dessalegn H ; Kassa, Getachew Mullu ; Kassa, Tesfaye Dessale ; Kassebaum, Nicholas ; Katikireddi, Srinivasa V ; kawakami, Norito ; Karyani, Ali Kazemi ; Keighobadi, Masoud M. ; Keiyoro, Peter Njenga ; Kemmer, Laura ; Kemp, Grant R. ; Kengne, Andre P ; Keren, Andre ; Khader, Yousef ; Khafaei, Behzad ; Khafaie, Morteza Abdullatif ; Khajavi, Alireza ; Khalil, Ibrahim ; Khan, E. A. ; Khan, Muhammad Shahzeb ; Khan, Muhammad Ali ; Khang, Young-Ho ; Khazaeipour, Zahra ; Khoja, Abdullah T ; Khosravi, A. ; Khosravi, Mohammad Hossein ; Ahmad Kiadaliri, Aliasghar ; Kiirithio, Daniel N. ; Kim, Cho-Il ; Kim, Daniel ; Kim, Pauline ; Kim, Young-Eun ; Kim, Yun J ; Kimokoti, Ruth ; KINFU, Yohannes ; Kisa, Adnan ; Kissimova-Skarbek, Katarzyna ; Kivimäki, Mika ; Knudsen, Ann K. S. ; Kocarnik, Jonathan M ; Kochhar, Sonali ; Kokubo, Yoshihiro ; Kolola, Tufa ; Kopec, Jacek A ; Kosen, Soewarta ; Kotsakis, Georgios A. ; Koul, P. A. ; Koyanagi, A. ; Kravchenko, Michael A ; Krishan, Kewal ; Krohn, Kristopher J. ; Defo, Barthelemy Kuate ; Bicer, B. Kucuk ; Kumar, G ; Kumar, Manasi ; Kyu, Hmwehmwe ; Lad, Deepesh P ; Lad, Sheetal D ; Lafranconi, Alessandra ; Lalloo, Ratilal ; Lallukka, Tea ; Al Lami, Faris Hasan ; Lansingh, Van C ; Latifi, Arman ; Lau, Kathryn Mei-Ming ; Lazarus, Jeffrey V ; Leasher, Janet ; Ledesma, Jorge R ; Lee, Paul H ; Leigh, James ; Leung, Janni ; Levi, Miriam ; Lewycka, Sonia ; Li, Shanshan ; Li, Yichong ; Liao, Yu ; Liben, Misgan Legesse ; Lim, Lee-Ling ; Lim, Stephen ; Liu, Shiwei ; Lodha, Rakesh ; Looker, Katharine ; Lopez, Alan ; Lorkowski, Stefan ; Lotufo, Paulo ; Low, Nicola ; Lozano, Rafael ; Lucas, Timothy ; Lucchesi, Lydia R ; Lunevicius, Raimundas ; Lyons, Ronan ; Ma, Stefan ; Macarayan, Erlyn Rachelle King ; Mackay, Mark T ; Madotto, Fabiana ; Abd El Razek, H. Magdy ; Razek, Mohamed Magdy Abd El ; Maghavani, Dhaval P ; Mahotra, Narayan Bahadur ; Mai, Hue Thi ; Majdan, Marek ; Majdzadeh, Reza ; Majeed, Azeem ; Malekzadeh, Reza ; Malta, Deborah C ; Mamun, Abdullah A ; Manda, Ana-Laura ; Manguerra, Helena ; Manhertz, Treh ; Mansournia, Mohammad A. ; Mantovani, Lorenzo G. ; Mapoma, Christopher ; Maravilla, Joemer C ; MArcenes, wagner ; Marks, Ashley ; Martins-Melo, Francisco Rogerlândio ; Martopullo, Ira ; März, Winfried ; Marzan, M. B. ; Mashamba-Thompson, Tivani Phosa ; Massenburg, Benjamin Ballard ; Mathur, Manu Raj ; Matsushita, Kunihiro ; Maulik, Pallab K ; Mazidi, Mohsen ; McAlinden, Colm . / Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017 : a systematic analysis for the Global Burden of Disease Study 2017. In: The Lancet. 2018 ; Vol. 392, No. 10159. pp. 1789-1858.
@article{e41ee427e22a482aaec640aea2be7688,
title = "Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017",
abstract = "Background: The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) includes a comprehensive assessment of incidence, prevalence, and years lived with disability (YLDs) for 354 causes in 195 countries and territories from 1990 to 2017. Previous GBD studies have shown how the decline of mortality rates from 1990 to 2016 has led to an increase in life expectancy, an ageing global population, and an expansion of the non-fatal burden of disease and injury. These studies have also shown how a substantial portion of the world's population experiences non-fatal health loss with considerable heterogeneity among different causes, locations, ages, and sexes. Ongoing objectives of the GBD study include increasing the level of estimation detail, improving analytical strategies, and increasing the amount of high-quality data. Methods: We estimated incidence and prevalence for 354 diseases and injuries and 3484 sequelae. We used an updated and extensive body of literature studies, survey data, surveillance data, inpatient admission records, outpatient visit records, and health insurance claims, and additionally used results from cause of death models to inform estimates using a total of 68 781 data sources. Newly available clinical data from India, Iran, Japan, Jordan, Nepal, China, Brazil, Norway, and Italy were incorporated, as well as updated claims data from the USA and new claims data from Taiwan (province of China) and Singapore. We used DisMod-MR 2.1, a Bayesian meta-regression tool, as the main method of estimation, ensuring consistency between rates of incidence, prevalence, remission, and cause of death for each condition. YLDs were estimated as the product of a prevalence estimate and a disability weight for health states of each mutually exclusive sequela, adjusted for comorbidity. We updated the Socio-demographic Index (SDI), a summary development indicator of income per capita, years of schooling, and total fertility rate. Additionally, we calculated differences between male and female YLDs to identify divergent trends across sexes. GBD 2017 complies with the Guidelines for Accurate and Transparent Health Estimates Reporting. Findings: Globally, for females, the causes with the greatest age-standardised prevalence were oral disorders, headache disorders, and haemoglobinopathies and haemolytic anaemias in both 1990 and 2017. For males, the causes with the greatest age-standardised prevalence were oral disorders, headache disorders, and tuberculosis including latent tuberculosis infection in both 1990 and 2017. In terms of YLDs, low back pain, headache disorders, and dietary iron deficiency were the leading Level 3 causes of YLD counts in 1990, whereas low back pain, headache disorders, and depressive disorders were the leading causes in 2017 for both sexes combined. All-cause age-standardised YLD rates decreased by 3·9{\%} (95{\%} uncertainty interval [UI] 3·1–4·6) from 1990 to 2017; however, the all-age YLD rate increased by 7·2{\%} (6·0–8·4) while the total sum of global YLDs increased from 562 million (421–723) to 853 million (642–1100). The increases for males and females were similar, with increases in all-age YLD rates of 7·9{\%} (6·6–9·2) for males and 6·5{\%} (5·4–7·7) for females. We found significant differences between males and females in terms of age-standardised prevalence estimates for multiple causes. The causes with the greatest relative differences between sexes in 2017 included substance use disorders (3018 cases [95{\%} UI 2782–3252] per 100 000 in males vs s1400 [1279–1524] per 100 000 in females), transport injuries (3322 [3082–3583] vs 2336 [2154–2535]), and self-harm and interpersonal violence (3265 [2943–3630] vs 5643 [5057–6302]). Interpretation: Global all-cause age-standardised YLD rates have improved only slightly over a period spanning nearly three decades. However, the magnitude of the non-fatal disease burden has expanded globally, with increasing numbers of people who have a wide spectrum of conditions. A subset of conditions has remained globally pervasive since 1990, whereas other conditions have displayed more dynamic trends, with different ages, sexes, and geographies across the globe experiencing varying burdens and trends of health loss. This study emphasises how global improvements in premature mortality for select conditions have led to older populations with complex and potentially expensive diseases, yet also highlights global achievements in certain domains of disease and injury. Funding: Bill & Melinda Gates Foundation.",
keywords = "Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Child, Child, Preschool, Disabled Persons/statistics & numerical data, Female, Global Burden of Disease/statistics & numerical data, Global Health/statistics & numerical data, Humans, Incidence, Infant, Infant, Newborn, Life Expectancy, Male, Middle Aged, Morbidity/trends, Prevalence, Sex Distribution, Socioeconomic Factors, Wounds and Injuries/epidemiology, Young Adult",
author = "{GBD 2017 Disease and Injury Incidence and Prevalence Collaborators} and James, {Spencer L.} and Degu Abate and Abate, {Kalkidan Hassen} and Abay, {Solomon M.} and Cristiana Abbafati and Nooshin Abbasi and Hedayat Abbastabar and Foad Abd-Allah and Jemal Abdela and Ahmed Abdelalim and Ibrahim Abdollahpour and Abdulkader, {Rizwan Suliankatchi} and Zegeye Abebe and Abera, {Semaw F.} and Abil, {Olifan Zewdie} and Abraha, {Haftom Niguse} and Abu-Raddad, {Laith Jamal} and Abu-Rmeileh, {Niveen M.E.} and Accrombessi, {Manfred Mario Kokou} and Dilaram Acharya and Pawan Acharya and Ackerman, {Ilana N.} and Adamu, {Abdu A.} and Adebayo, {Oladimeji M.} and Victor Adekanmbi and Adetokunboh, {Olatunji O.} and Adib, {Mina G.} and Adsuar, {Jose C.} and Afanvi, {Kossivi Agbelenko} and Mohsen Afarideh and Ashkan Afshin and Gina Agarwal and Agesa, {Kareha M.} and Rakesh Aggarwal and Aghayan, {Sargis Aghasi} and Sutapa Agrawal and Alireza Ahmadi and Mehdi Ahmadi and Hamid Ahmadieh and Ahmed, {Muktar Beshir} and Aichour, {Amani Nidhal} and Ibtihel Aichour and Aichour, {Miloud Taki Eddine} and Tomi Akinyemiju and Nadia Akseer and Ziyad Al-Aly and Ayman Al-Eyadhy and Al-Mekhlafi, {Hesham M.} and Al-Raddadi, {Rajaa M.} and Fares Alahdab and Khurshid Alam and Tahiya Alam and Alaa Alashi and Alavian, {Seyed Moayed} and Alene, {Kefyalew Addis} and Mehran Alijanzadeh and Reza Alizadeh-Navaei and Aljunid, {Syed Mohamed} and Ala'a Alkerwi and Fran{\cc}ois Alla and Peter Allebeck and Alouani, {Mohamed M.L.} and Khalid Altirkawi and Nelson Alvis-Guzman and Amare, {Azmeraw T.} and Aminde, {Leopold N.} and Walid Ammar and Amoako, {Yaw Ampem} and Anber, {Nahla Hamed} and Andrei, {Catalina Liliana} and Sofia Androudi and Animut, {Megbaru Debalkie} and Mina Anjomshoa and Ansha, {Mustafa Geleto} and Antonio, {Carl Abelardo T.} and Palwasha Anwari and Jalal Arabloo and Antonio Arauz and Olatunde Aremu and Filippo Ariani and Bahroom Armoon and Johan {\"A}rnl{\"o}v and Amit Arora and Al Artaman and Aryal, {Krishna K.} and Hamid Asayesh and Asghar, {Rana Jawad} and Zerihun Ataro and Atre, {Sachin R.} and Marcel Ausloos and Leticia Avila-Burgos and Avokpaho, {Euripide F.G.A.} and Ashish Awasthi and {Ayala Quintanilla}, {Beatriz Paulina} and Rakesh Ayer and Azzopardi, {Peter S.} and Arefeh Babazadeh and Hamid Badali and Alaa Badawi and Bali, {Ayele Geleto} and Ballesteros, {Katherine E.} and Ballew, {Shoshana H.} and Maciej Banach and Banoub, {Joseph Adel Mattar} and Amrit Banstola and Aleksandra Barac and Barboza, {Miguel A.} and Barker-Collo, {Suzanne Lyn} and B{\"a}rnighausen, {Till Winfried} and Barrero, {Lope H.} and Baune, {Bernhard T.} and Shahrzad Bazargan-Hejazi and Neeraj Bedi and Ettore Beghi and Masoud Behzadifar and Meysam Behzadifar and Yannick B{\'e}jot and Belachew, {Abate Bekele} and Belay, {Yihalem Abebe} and Bell, {Michelle L.} and Bello, {Aminu K.} and Bensenor, {Isabela M.} and Eduardo Bernabe and Bernstein, {Robert S.} and Mircea Beuran and Tina Beyranvand and Neeraj Bhala and Suraj Bhattarai and Soumyadeep Bhaumik and Bhutta, {Zulfiqar A.} and Belete Biadgo and Ali Bijani and Boris Bikbov and Ver Bilano and Nigus Bililign and {Bin Sayeed}, {Muhammad Shahdaat} and Donal Bisanzio and Blacker, {Brigette F.} and Blyth, {Fiona M.} and Bou-Orm, {Ibrahim R.} and Soufiane Boufous and Rupert Bourne and Brady, {Oliver J.} and Michael Brainin and Brant, {Luisa C.} and Alexandra Brazinova and Breitborde, {Nicholas J.K.} and Hermann Brenner and Briant, {Paul Svitil} and Briggs, {Andrew M.} and Briko, {Andrey Nikolaevich} and Gabrielle Britton and Traolach Brugha and Rachelle Buchbinder and Reinhard Busse and Butt, {Zahid A.} and Lucero Cahuana-Hurtado and Jorge Cano and Rosario C{\'a}rdenas and Carrero, {Juan J.} and Austin Carter and F{\'e}lix Carvalho and Casta{\~n}eda-Orjuela, {Carlos A.} and {Castillo Rivas}, Jacqueline and Franz Castro and Ferr{\'a}n Catal{\'a}-L{\'o}pez and Cercy, {Kelly M.} and Ester Cerin and Yazan Chaiah and Chang, {Alex R.} and Chang, {Hsing Yi} and Chang, {Jung Chen} and Charlson, {Fiona J.} and Aparajita Chattopadhyay and Chattu, {Vijay Kumar} and Pankaj Chaturvedi and Chiang, {Peggy Pei Chia} and Chin, {Ken Lee} and Abdulaal Chitheer and Choi, {Jee Young J.} and Rajiv Chowdhury and Hanne Christensen and Christopher, {Devasahayam J.} and Cicuttini, {Flavia M.} and Ciobanu, {Liliana G.} and Massimo Cirillo and Claro, {Rafael M.} and Daniel Collado-Mateo and Cyrus Cooper and Josef Coresh and Cortesi, {Paolo Angelo} and Monica Cortinovis and Megan Costa and Ewerton Cousin and Criqui, {Michael H.} and Cromwell, {Elizabeth A.} and Marita Cross and Crump, {John A.} and Dadi, {Abel Fekadu} and Lalit Dandona and Rakhi Dandona and Dargan, {Paul I.} and Ahmad Daryani and {Das Gupta}, Rajat and {Das Neves}, Jos{\'e} and Dasa, {Tamirat Tesfaye} and Gail Davey and Davis, {Adrian C.} and Davitoiu, {Dragos Virgil} and {De Courten}, Barbora and {De La Hoz}, {Fernando Pio} and {De Leo}, Diego and {De Neve}, {Jan Walter} and Degefa, {Meaza Girma} and Louisa Degenhardt and Selina Deiparine and Dellavalle, {Robert P.} and Demoz, {Gebre Teklemariam} and Kebede Deribe and Nikolaos Dervenis and {Des Jarlais}, {Don C.} and Dessie, {Getenet Ayalew} and Subhojit Dey and Dharmaratne, {Samath Dhamminda} and Dinberu, {Mesfin Tadese} and Dirac, {M. Ashworth} and Shirin Djalalinia and Linh Doan and Klara Dokova and Doku, {David Teye} and Dorsey, {E. Ray} and Doyle, {Kerrie E.} and Driscoll, {Tim Robert} and Manisha Dubey and Eleonora Dubljanin and Duken, {Eyasu Ejeta} and Duncan, {Bruce B.} and Duraes, {Andre R.} and Hedyeh Ebrahimi and Soheil Ebrahimpour and Echko, {Michelle Marie} and David Edvardsson and Andem Effiong and Ehrlich, {Joshua R.} and {El Bcheraoui}, Charbel and Maysaa Zaki and Ziad El-Khatib and Hajer Elkout and I. Elyazar and Ahmadali Enayati and Endries, {Aman Yesuf} and Benjamin Er and Erskine, {Holly E.} and Babak Eshrati and Sharareh Eskandarieh and Alireza Esteghamati and Sadaf Esteghamati and Hamed Fakhim and {Fallah Omrani}, Vahid and Mahbobeh Faramarzi and Mohammad Fareed and Farzaneh Farhadi and Talha Farid and Farinha, {C. S.E.S.} and Andrea Farioli and Andr{\'e} Faro and Maryam Farvid and Farshad Farzadfar and Feigin, {Valery L.} and Netsanet Fentahun and Seyed-Mohammad Fereshtehnejad and Eduarda Fernandes and Fernandes, {Jo{\~a}o C} and Ferrari, {Alize J.} and Garumma Feyissa and Irina Filip and Florian Fischer and Christina Fitzmaurice and Nataliya Foigt and Foreman, {Kyle J.} and Jack Fox and Tahvi Frank and Takeshi Fukumoto and Nancy Fullman and Thomas F{\"u}rst and Jo{\~a}o Furtado and Futran, {Neal D.} and Seana Gall and Morsaleh Ganji and Fortun{\'e} Gankp{\'e} and Alberto Garcia-Basteiro and William Gardner and Abadi Gebre and Gebremedhin, {A. T.} and Teklu Gebremichael and Tilayie Gelano and Johanna Geleijnse and Ricard Genova-Maleras and Yilma Geramo and Peter Gething and Kebede Gezae and Keyghobad Ghadiri and Khalil Falavarjani and Maryam Ghasemi-Kasman and Mamata Ghimire and Rakesh Ghosh and Aloke Ghoshal and Simona Giampaoli and Paramjit Gill and Gill, {Tiffany K.} and Ibrahim Ginawi and Giorgia Giussani and Elena Gnedovskaya and Ellen Goldberg and Srinivas Goli and H. G{\'o}mez-Dant{\'e}s and Gona, {Philimon N} and Gopalani, {S. V.} and Taren Gorman and Alessandra Goulart and B{\'a}rbara Goulart and Ayman Grada and Morgan Grams and Giuseppe Grosso and Harish Gugnani and Yuming Guo and Prakash Gupta and Rahul Gupta and Rajeev Gupta and Tanush Gupta and Bishal Gyawali and Haagsma, {Juanita A.} and Vladimir Hachinski and Nima Hafezi-Nejad and Hassan Haghparast-Bidgoli and Hagos, {Tekleberhan B.} and Hailu, {G. B.} and Arvin Haj-Mirzaian and Randah Hamadeh and Samer Hamidi and Alexis Handal and Hankey, {Graeme J.} and Yuantao Hao and Hilda Harb and Hadi Hassankhani and Hassen, {Hamid Yimam} and Rasmus Havmoeller and Caitlin Hawley and Hay, {Roderick J.} and Simon Hay and Akbar Hedayatizadeh-Omran and Behzad Heibati and Delia Hendrie and Andualem Henok and Claudia Herteliu and Sousan Heydarpour and Hibstu, {Desalegn T} and Hoang, {Huong Tranh} and Hoek, {Hans W.} and Howard Hoffman and Hole, {Michael K.} and Rad, {Enayatollah Homaie} and Praveen Hoogar and HDean Hosgood and Hosseini, {Seyed M.} and Mehdi Hosseinzadeh and Mihaela Hostiuc and Sorin Hostiuc and Hotez, {Peter J.} and Damian Hoy and Mohamed Hsairi and Htet, {Aung Soe} and Guoqing Hu and John Huang and Chantal Huynh and Iburg, {Kim Moesgaard} and Chad Ikeda and Ileanu, {Bogdan Vasile} and {Stephen Ilesanmi}, Olayinka and Usman Iqbal and Irvani, {Seyed S. N.} and Caleb Irvine and Islam, {Sheikh Mohammed Shariful} and Farhad Islami and Jacobsen, {K. H.} and Leila Jahangiry and Nader Jahanmehr and Jain, {Sudhir Kumar} and Jakovljevic, {M. B.} and Mehdi Javanbakht and Jayatilleke, {A. U.} and Panniyammakal Jeemon and Jha, {Ravi Prakash} and Vivekanand Jha and Ji, {John S} and Johnson, {Catherine O} and Jonas, {Jost B.} and Jacek Jozwiak and Suresh Jungari and Mikk J{\"u}risson and Zubair Kabir and Rajendra Kadel and Amaha Kahsay and Rizwan Kalani and Tanuj Kanchan and Manoochehr Karami and Matin, {Behzad Karami} and Andr{\'e} Karch and Corine Karema and Narges Karimi and Karimi, {Seyed M} and Amir Kasaeian and Kassa, {Dessalegn H} and Kassa, {Getachew Mullu} and Kassa, {Tesfaye Dessale} and Nicholas Kassebaum and Katikireddi, {Srinivasa V} and Norito kawakami and Karyani, {Ali Kazemi} and Keighobadi, {Masoud M.} and Keiyoro, {Peter Njenga} and Laura Kemmer and Kemp, {Grant R.} and Kengne, {Andre P} and Andre Keren and Yousef Khader and Behzad Khafaei and Khafaie, {Morteza Abdullatif} and Alireza Khajavi and Ibrahim Khalil and Khan, {E. A.} and Khan, {Muhammad Shahzeb} and Khan, {Muhammad Ali} and Young-Ho Khang and Zahra Khazaeipour and Khoja, {Abdullah T} and A. Khosravi and Khosravi, {Mohammad Hossein} and {Ahmad Kiadaliri}, Aliasghar and Kiirithio, {Daniel N.} and Cho-Il Kim and Daniel Kim and Pauline Kim and Young-Eun Kim and Kim, {Yun J} and Ruth Kimokoti and Yohannes KINFU and Adnan Kisa and Katarzyna Kissimova-Skarbek and Mika Kivim{\"a}ki and Knudsen, {Ann K. S.} and Kocarnik, {Jonathan M} and Sonali Kochhar and Yoshihiro Kokubo and Tufa Kolola and Kopec, {Jacek A} and Soewarta Kosen and Kotsakis, {Georgios A.} and Koul, {P. A.} and A. Koyanagi and Kravchenko, {Michael A} and Kewal Krishan and Krohn, {Kristopher J.} and Defo, {Barthelemy Kuate} and Bicer, {B. Kucuk} and G Kumar and Manasi Kumar and Hmwehmwe Kyu and Lad, {Deepesh P} and Lad, {Sheetal D} and Alessandra Lafranconi and Ratilal Lalloo and Tea Lallukka and {Al Lami}, {Faris Hasan} and Lansingh, {Van C} and Arman Latifi, and Lau, {Kathryn Mei-Ming} and Lazarus, {Jeffrey V} and Janet Leasher and Ledesma, {Jorge R} and Lee, {Paul H} and James Leigh and Janni Leung and Miriam Levi and Sonia Lewycka and Shanshan Li and Yichong Li and Yu Liao and Liben, {Misgan Legesse} and Lee-Ling Lim and Stephen Lim and Shiwei Liu and Rakesh Lodha and Katharine Looker and Alan Lopez and Stefan Lorkowski and Paulo Lotufo and Nicola Low and Rafael Lozano and Timothy Lucas and Lucchesi, {Lydia R} and Raimundas Lunevicius and Ronan Lyons and Stefan Ma and Macarayan, {Erlyn Rachelle King} and Mackay, {Mark T} and Fabiana Madotto and {Abd El Razek}, {H. Magdy} and Razek, {Mohamed Magdy Abd El} and Maghavani, {Dhaval P} and Mahotra, {Narayan Bahadur} and Mai, {Hue Thi} and Marek Majdan and Reza Majdzadeh and Azeem Majeed and Reza Malekzadeh and Malta, {Deborah C} and Mamun, {Abdullah A} and Ana-Laura Manda and Helena Manguerra and Treh Manhertz and Mansournia, {Mohammad A.} and Mantovani, {Lorenzo G.} and Christopher Mapoma and Maravilla, {Joemer C} and wagner MArcenes and Ashley Marks and Martins-Melo, {Francisco Rogerl{\^a}ndio} and Ira Martopullo and Winfried M{\"a}rz and Marzan, {M. B.} and Mashamba-Thompson, {Tivani Phosa} and Massenburg, {Benjamin Ballard} and Mathur, {Manu Raj} and Kunihiro Matsushita and Maulik, {Pallab K} and Mohsen Mazidi and Colm McAlinden",
year = "2018",
month = "11",
day = "10",
doi = "10.1016/S0140-6736(18)32279-7",
language = "English",
volume = "392",
pages = "1789--1858",
journal = "Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "10159",

}

GBD 2017 Disease and Injury Incidence and Prevalence Collaborators, Karimi, N, Karimi, SM, Kasaeian, A, Kassa, DH, Kassa, GM, Kassa, TD, Kassebaum, N, Katikireddi, SV, kawakami, N, Karyani, AK, Keighobadi, MM, Keiyoro, PN, Kemmer, L, Kemp, GR, Kengne, AP, Keren, A, Khader, Y, Khafaei, B, Khafaie, MA, Khajavi, A, Khalil, I, Khan, EA, Khan, MS, Khan, MA, Khang, Y-H, Khazaeipour, Z, Khoja, AT, Khosravi, A, Khosravi, MH, Ahmad Kiadaliri, A, Kiirithio, DN, Kim, C-I, Kim, D, Kim, P, Kim, Y-E, Kim, YJ, Kimokoti, R, KINFU, Y, Kisa, A, Kissimova-Skarbek, K, Kivimäki, M, Knudsen, AKS, Kocarnik, JM, Kochhar, S, Kokubo, Y, Kolola, T, Kopec, JA, Kosen, S, Kotsakis, GA, Koul, PA, Koyanagi, A, Kravchenko, MA, Krishan, K, Krohn, KJ, Defo, BK, Bicer, BK, Kumar, G, Kumar, M, Kyu, H, Lad, DP, Lad, SD, Lafranconi, A, Lalloo, R, Lallukka, T, Al Lami, FH, Lansingh, VC, Latifi, A, Lau, KM-M, Lazarus, JV, Leasher, J, Ledesma, JR, Lee, PH, Leigh, J, Leung, J, Levi, M, Lewycka, S, Li, S, Li, Y, Liao, Y, Liben, ML, Lim, L-L, Lim, S, Liu, S, Lodha, R, Looker, K, Lopez, A, Lorkowski, S, Lotufo, P, Low, N, Lozano, R, Lucas, T, Lucchesi, LR, Lunevicius, R, Lyons, R, Ma, S, Macarayan, ERK, Mackay, MT, Madotto, F, Abd El Razek, HM, Razek, MMAE, Maghavani, DP, Mahotra, NB, Mai, HT, Majdan, M, Majdzadeh, R, Majeed, A, Malekzadeh, R, Malta, DC, Mamun, AA, Manda, A-L, Manguerra, H, Manhertz, T, Mansournia, MA, Mantovani, LG, Mapoma, C, Maravilla, JC, MArcenes, W, Marks, A, Martins-Melo, FR, Martopullo, I, März, W, Marzan, MB, Mashamba-Thompson, TP, Massenburg, BB, Mathur, MR, Matsushita, K, Maulik, PK, Mazidi, M & McAlinden, C 2018, 'Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017', The Lancet, vol. 392, no. 10159, pp. 1789-1858. https://doi.org/10.1016/S0140-6736(18)32279-7

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017 : a systematic analysis for the Global Burden of Disease Study 2017. / GBD 2017 Disease and Injury Incidence and Prevalence Collaborators; Karimi, Narges; Karimi, Seyed M ; Kasaeian, Amir; Kassa, Dessalegn H ; Kassa, Getachew Mullu ; Kassa, Tesfaye Dessale ; Kassebaum, Nicholas; Katikireddi, Srinivasa V; kawakami, Norito; Karyani, Ali Kazemi ; Keighobadi, Masoud M.; Keiyoro, Peter Njenga; Kemmer, Laura; Kemp, Grant R.; Kengne, Andre P; Keren, Andre; Khader, Yousef; Khafaei, Behzad ; Khafaie, Morteza Abdullatif ; Khajavi, Alireza ; Khalil, Ibrahim; Khan, E. A.; Khan, Muhammad Shahzeb ; Khan, Muhammad Ali ; Khang, Young-Ho; Khazaeipour, Zahra ; Khoja, Abdullah T ; Khosravi, A.; Khosravi, Mohammad Hossein ; Ahmad Kiadaliri, Aliasghar; Kiirithio, Daniel N.; Kim, Cho-Il; Kim, Daniel; Kim, Pauline; Kim, Young-Eun ; Kim, Yun J; Kimokoti, Ruth; KINFU, Yohannes; Kisa, Adnan ; Kissimova-Skarbek, Katarzyna ; Kivimäki, Mika ; Knudsen, Ann K. S.; Kocarnik, Jonathan M ; Kochhar, Sonali ; Kokubo, Yoshihiro; Kolola, Tufa ; Kopec, Jacek A ; Kosen, Soewarta; Kotsakis, Georgios A.; Koul, P. A.; Koyanagi, A.; Kravchenko, Michael A ; Krishan, Kewal ; Krohn, Kristopher J.; Defo, Barthelemy Kuate; Bicer, B. Kucuk; Kumar, G; Kumar, Manasi ; Kyu, Hmwehmwe; Lad, Deepesh P ; Lad, Sheetal D ; Lafranconi, Alessandra ; Lalloo, Ratilal; Lallukka, Tea; Al Lami, Faris Hasan; Lansingh, Van C ; Latifi, Arman; Lau, Kathryn Mei-Ming ; Lazarus, Jeffrey V ; Leasher, Janet; Ledesma, Jorge R; Lee, Paul H ; Leigh, James; Leung, Janni; Levi, Miriam; Lewycka, Sonia ; Li, Shanshan ; Li, Yichong; Liao, Yu; Liben, Misgan Legesse ; Lim, Lee-Ling ; Lim, Stephen; Liu, Shiwei; Lodha, Rakesh ; Looker, Katharine; Lopez, Alan; Lorkowski, Stefan ; Lotufo, Paulo; Low, Nicola; Lozano, Rafael; Lucas, Timothy; Lucchesi, Lydia R ; Lunevicius, Raimundas; Lyons, Ronan; Ma, Stefan; Macarayan, Erlyn Rachelle King ; Mackay, Mark T ; Madotto, Fabiana ; Abd El Razek, H. Magdy; Razek, Mohamed Magdy Abd El; Maghavani, Dhaval P ; Mahotra, Narayan Bahadur ; Mai, Hue Thi; Majdan, Marek; Majdzadeh, Reza ; Majeed, Azeem; Malekzadeh, Reza; Malta, Deborah C; Mamun, Abdullah A ; Manda, Ana-Laura ; Manguerra, Helena; Manhertz, Treh; Mansournia, Mohammad A.; Mantovani, Lorenzo G.; Mapoma, Christopher; Maravilla, Joemer C ; MArcenes, wagner; Marks, Ashley ; Martins-Melo, Francisco Rogerlândio ; Martopullo, Ira; März, Winfried; Marzan, M. B.; Mashamba-Thompson, Tivani Phosa; Massenburg, Benjamin Ballard ; Mathur, Manu Raj ; Matsushita, Kunihiro; Maulik, Pallab K ; Mazidi, Mohsen; McAlinden, Colm .

In: The Lancet, Vol. 392, No. 10159, 10.11.2018, p. 1789-1858.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017

T2 - a systematic analysis for the Global Burden of Disease Study 2017

AU - GBD 2017 Disease and Injury Incidence and Prevalence Collaborators

AU - James, Spencer L.

AU - Abate, Degu

AU - Abate, Kalkidan Hassen

AU - Abay, Solomon M.

AU - Abbafati, Cristiana

AU - Abbasi, Nooshin

AU - Abbastabar, Hedayat

AU - Abd-Allah, Foad

AU - Abdela, Jemal

AU - Abdelalim, Ahmed

AU - Abdollahpour, Ibrahim

AU - Abdulkader, Rizwan Suliankatchi

AU - Abebe, Zegeye

AU - Abera, Semaw F.

AU - Abil, Olifan Zewdie

AU - Abraha, Haftom Niguse

AU - Abu-Raddad, Laith Jamal

AU - Abu-Rmeileh, Niveen M.E.

AU - Accrombessi, Manfred Mario Kokou

AU - Acharya, Dilaram

AU - Acharya, Pawan

AU - Ackerman, Ilana N.

AU - Adamu, Abdu A.

AU - Adebayo, Oladimeji M.

AU - Adekanmbi, Victor

AU - Adetokunboh, Olatunji O.

AU - Adib, Mina G.

AU - Adsuar, Jose C.

AU - Afanvi, Kossivi Agbelenko

AU - Afarideh, Mohsen

AU - Afshin, Ashkan

AU - Agarwal, Gina

AU - Agesa, Kareha M.

AU - Aggarwal, Rakesh

AU - Aghayan, Sargis Aghasi

AU - Agrawal, Sutapa

AU - Ahmadi, Alireza

AU - Ahmadi, Mehdi

AU - Ahmadieh, Hamid

AU - Ahmed, Muktar Beshir

AU - Aichour, Amani Nidhal

AU - Aichour, Ibtihel

AU - Aichour, Miloud Taki Eddine

AU - Akinyemiju, Tomi

AU - Akseer, Nadia

AU - Al-Aly, Ziyad

AU - Al-Eyadhy, Ayman

AU - Al-Mekhlafi, Hesham M.

AU - Al-Raddadi, Rajaa M.

AU - Alahdab, Fares

AU - Alam, Khurshid

AU - Alam, Tahiya

AU - Alashi, Alaa

AU - Alavian, Seyed Moayed

AU - Alene, Kefyalew Addis

AU - Alijanzadeh, Mehran

AU - Alizadeh-Navaei, Reza

AU - Aljunid, Syed Mohamed

AU - Alkerwi, Ala'a

AU - Alla, François

AU - Allebeck, Peter

AU - Alouani, Mohamed M.L.

AU - Altirkawi, Khalid

AU - Alvis-Guzman, Nelson

AU - Amare, Azmeraw T.

AU - Aminde, Leopold N.

AU - Ammar, Walid

AU - Amoako, Yaw Ampem

AU - Anber, Nahla Hamed

AU - Andrei, Catalina Liliana

AU - Androudi, Sofia

AU - Animut, Megbaru Debalkie

AU - Anjomshoa, Mina

AU - Ansha, Mustafa Geleto

AU - Antonio, Carl Abelardo T.

AU - Anwari, Palwasha

AU - Arabloo, Jalal

AU - Arauz, Antonio

AU - Aremu, Olatunde

AU - Ariani, Filippo

AU - Armoon, Bahroom

AU - Ärnlöv, Johan

AU - Arora, Amit

AU - Artaman, Al

AU - Aryal, Krishna K.

AU - Asayesh, Hamid

AU - Asghar, Rana Jawad

AU - Ataro, Zerihun

AU - Atre, Sachin R.

AU - Ausloos, Marcel

AU - Avila-Burgos, Leticia

AU - Avokpaho, Euripide F.G.A.

AU - Awasthi, Ashish

AU - Ayala Quintanilla, Beatriz Paulina

AU - Ayer, Rakesh

AU - Azzopardi, Peter S.

AU - Babazadeh, Arefeh

AU - Badali, Hamid

AU - Badawi, Alaa

AU - Bali, Ayele Geleto

AU - Ballesteros, Katherine E.

AU - Ballew, Shoshana H.

AU - Banach, Maciej

AU - Banoub, Joseph Adel Mattar

AU - Banstola, Amrit

AU - Barac, Aleksandra

AU - Barboza, Miguel A.

AU - Barker-Collo, Suzanne Lyn

AU - Bärnighausen, Till Winfried

AU - Barrero, Lope H.

AU - Baune, Bernhard T.

AU - Bazargan-Hejazi, Shahrzad

AU - Bedi, Neeraj

AU - Beghi, Ettore

AU - Behzadifar, Masoud

AU - Behzadifar, Meysam

AU - Béjot, Yannick

AU - Belachew, Abate Bekele

AU - Belay, Yihalem Abebe

AU - Bell, Michelle L.

AU - Bello, Aminu K.

AU - Bensenor, Isabela M.

AU - Bernabe, Eduardo

AU - Bernstein, Robert S.

AU - Beuran, Mircea

AU - Beyranvand, Tina

AU - Bhala, Neeraj

AU - Bhattarai, Suraj

AU - Bhaumik, Soumyadeep

AU - Bhutta, Zulfiqar A.

AU - Biadgo, Belete

AU - Bijani, Ali

AU - Bikbov, Boris

AU - Bilano, Ver

AU - Bililign, Nigus

AU - Bin Sayeed, Muhammad Shahdaat

AU - Bisanzio, Donal

AU - Blacker, Brigette F.

AU - Blyth, Fiona M.

AU - Bou-Orm, Ibrahim R.

AU - Boufous, Soufiane

AU - Bourne, Rupert

AU - Brady, Oliver J.

AU - Brainin, Michael

AU - Brant, Luisa C.

AU - Brazinova, Alexandra

AU - Breitborde, Nicholas J.K.

AU - Brenner, Hermann

AU - Briant, Paul Svitil

AU - Briggs, Andrew M.

AU - Briko, Andrey Nikolaevich

AU - Britton, Gabrielle

AU - Brugha, Traolach

AU - Buchbinder, Rachelle

AU - Busse, Reinhard

AU - Butt, Zahid A.

AU - Cahuana-Hurtado, Lucero

AU - Cano, Jorge

AU - Cárdenas, Rosario

AU - Carrero, Juan J.

AU - Carter, Austin

AU - Carvalho, Félix

AU - Castañeda-Orjuela, Carlos A.

AU - Castillo Rivas, Jacqueline

AU - Castro, Franz

AU - Catalá-López, Ferrán

AU - Cercy, Kelly M.

AU - Cerin, Ester

AU - Chaiah, Yazan

AU - Chang, Alex R.

AU - Chang, Hsing Yi

AU - Chang, Jung Chen

AU - Charlson, Fiona J.

AU - Chattopadhyay, Aparajita

AU - Chattu, Vijay Kumar

AU - Chaturvedi, Pankaj

AU - Chiang, Peggy Pei Chia

AU - Chin, Ken Lee

AU - Chitheer, Abdulaal

AU - Choi, Jee Young J.

AU - Chowdhury, Rajiv

AU - Christensen, Hanne

AU - Christopher, Devasahayam J.

AU - Cicuttini, Flavia M.

AU - Ciobanu, Liliana G.

AU - Cirillo, Massimo

AU - Claro, Rafael M.

AU - Collado-Mateo, Daniel

AU - Cooper, Cyrus

AU - Coresh, Josef

AU - Cortesi, Paolo Angelo

AU - Cortinovis, Monica

AU - Costa, Megan

AU - Cousin, Ewerton

AU - Criqui, Michael H.

AU - Cromwell, Elizabeth A.

AU - Cross, Marita

AU - Crump, John A.

AU - Dadi, Abel Fekadu

AU - Dandona, Lalit

AU - Dandona, Rakhi

AU - Dargan, Paul I.

AU - Daryani, Ahmad

AU - Das Gupta, Rajat

AU - Das Neves, José

AU - Dasa, Tamirat Tesfaye

AU - Davey, Gail

AU - Davis, Adrian C.

AU - Davitoiu, Dragos Virgil

AU - De Courten, Barbora

AU - De La Hoz, Fernando Pio

AU - De Leo, Diego

AU - De Neve, Jan Walter

AU - Degefa, Meaza Girma

AU - Degenhardt, Louisa

AU - Deiparine, Selina

AU - Dellavalle, Robert P.

AU - Demoz, Gebre Teklemariam

AU - Deribe, Kebede

AU - Dervenis, Nikolaos

AU - Des Jarlais, Don C.

AU - Dessie, Getenet Ayalew

AU - Dey, Subhojit

AU - Dharmaratne, Samath Dhamminda

AU - Dinberu, Mesfin Tadese

AU - Dirac, M. Ashworth

AU - Djalalinia, Shirin

AU - Doan, Linh

AU - Dokova, Klara

AU - Doku, David Teye

AU - Dorsey, E. Ray

AU - Doyle, Kerrie E.

AU - Driscoll, Tim Robert

AU - Dubey, Manisha

AU - Dubljanin, Eleonora

AU - Duken, Eyasu Ejeta

AU - Duncan, Bruce B.

AU - Duraes, Andre R.

AU - Ebrahimi, Hedyeh

AU - Ebrahimpour, Soheil

AU - Echko, Michelle Marie

AU - Edvardsson, David

AU - Effiong, Andem

AU - Ehrlich, Joshua R.

AU - El Bcheraoui, Charbel

AU - Zaki, Maysaa

AU - El-Khatib, Ziad

AU - Elkout, Hajer

AU - Elyazar, I.

AU - Enayati, Ahmadali

AU - Endries, Aman Yesuf

AU - Er, Benjamin

AU - Erskine, Holly E.

AU - Eshrati, Babak

AU - Eskandarieh, Sharareh

AU - Esteghamati, Alireza

AU - Esteghamati, Sadaf

AU - Fakhim, Hamed

AU - Fallah Omrani, Vahid

AU - Faramarzi, Mahbobeh

AU - Fareed, Mohammad

AU - Farhadi, Farzaneh

AU - Farid, Talha

AU - Farinha, C. S.E.S.

AU - Farioli, Andrea

AU - Faro, André

AU - Farvid, Maryam

AU - Farzadfar, Farshad

AU - Feigin, Valery L.

AU - Fentahun, Netsanet

AU - Fereshtehnejad, Seyed-Mohammad

AU - Fernandes, Eduarda

AU - Fernandes, João C

AU - Ferrari, Alize J.

AU - Feyissa, Garumma

AU - Filip, Irina

AU - Fischer, Florian

AU - Fitzmaurice, Christina

AU - Foigt, Nataliya

AU - Foreman, Kyle J.

AU - Fox, Jack

AU - Frank, Tahvi

AU - Fukumoto, Takeshi

AU - Fullman, Nancy

AU - Fürst, Thomas

AU - Furtado, João

AU - Futran, Neal D.

AU - Gall, Seana

AU - Ganji, Morsaleh

AU - Gankpé, Fortuné

AU - Garcia-Basteiro, Alberto

AU - Gardner, William

AU - Gebre, Abadi

AU - Gebremedhin, A. T.

AU - Gebremichael, Teklu

AU - Gelano, Tilayie

AU - Geleijnse, Johanna

AU - Genova-Maleras, Ricard

AU - Geramo, Yilma

AU - Gething, Peter

AU - Gezae, Kebede

AU - Ghadiri, Keyghobad

AU - Falavarjani, Khalil

AU - Ghasemi-Kasman, Maryam

AU - Ghimire, Mamata

AU - Ghosh, Rakesh

AU - Ghoshal, Aloke

AU - Giampaoli, Simona

AU - Gill, Paramjit

AU - Gill, Tiffany K.

AU - Ginawi, Ibrahim

AU - Giussani, Giorgia

AU - Gnedovskaya, Elena

AU - Goldberg, Ellen

AU - Goli, Srinivas

AU - Gómez-Dantés, H.

AU - Gona, Philimon N

AU - Gopalani, S. V.

AU - Gorman, Taren

AU - Goulart, Alessandra

AU - Goulart, Bárbara

AU - Grada, Ayman

AU - Grams, Morgan

AU - Grosso, Giuseppe

AU - Gugnani, Harish

AU - Guo, Yuming

AU - Gupta, Prakash

AU - Gupta, Rahul

AU - Gupta, Rajeev

AU - Gupta, Tanush

AU - Gyawali, Bishal

AU - Haagsma, Juanita A.

AU - Hachinski, Vladimir

AU - Hafezi-Nejad, Nima

AU - Haghparast-Bidgoli, Hassan

AU - Hagos, Tekleberhan B.

AU - Hailu, G. B.

AU - Haj-Mirzaian, Arvin

AU - Hamadeh, Randah

AU - Hamidi, Samer

AU - Handal, Alexis

AU - Hankey, Graeme J.

AU - Hao, Yuantao

AU - Harb, Hilda

AU - Hassankhani, Hadi

AU - Hassen, Hamid Yimam

AU - Havmoeller, Rasmus

AU - Hawley, Caitlin

AU - Hay, Roderick J.

AU - Hay, Simon

AU - Hedayatizadeh-Omran, Akbar

AU - Heibati, Behzad

AU - Hendrie, Delia

AU - Henok, Andualem

AU - Herteliu, Claudia

AU - Heydarpour, Sousan

AU - Hibstu, Desalegn T

AU - Hoang, Huong Tranh

AU - Hoek, Hans W.

AU - Hoffman, Howard

AU - Hole, Michael K.

AU - Rad, Enayatollah Homaie

AU - Hoogar, Praveen

AU - Hosgood, HDean

AU - Hosseini, Seyed M.

AU - Hosseinzadeh, Mehdi

AU - Hostiuc, Mihaela

AU - Hostiuc, Sorin

AU - Hotez, Peter J.

AU - Hoy, Damian

AU - Hsairi, Mohamed

AU - Htet, Aung Soe

AU - Hu, Guoqing

AU - Huang, John

AU - Huynh, Chantal

AU - Iburg, Kim Moesgaard

AU - Ikeda, Chad

AU - Ileanu, Bogdan Vasile

AU - Stephen Ilesanmi, Olayinka

AU - Iqbal, Usman

AU - Irvani, Seyed S. N.

AU - Irvine, Caleb

AU - Islam, Sheikh Mohammed Shariful

AU - Islami, Farhad

AU - Jacobsen, K. H.

AU - Jahangiry, Leila

AU - Jahanmehr, Nader

AU - Jain, Sudhir Kumar

AU - Jakovljevic, M. B.

AU - Javanbakht, Mehdi

AU - Jayatilleke, A. U.

AU - Jeemon, Panniyammakal

AU - Jha, Ravi Prakash

AU - Jha, Vivekanand

AU - Ji, John S

AU - Johnson, Catherine O

AU - Jonas, Jost B.

AU - Jozwiak, Jacek

AU - Jungari, Suresh

AU - Jürisson, Mikk

AU - Kabir, Zubair

AU - Kadel, Rajendra

AU - Kahsay, Amaha

AU - Kalani, Rizwan

AU - Kanchan, Tanuj

AU - Karami, Manoochehr

AU - Matin, Behzad Karami

AU - Karch, André

AU - Karema, Corine

AU - Karimi, Narges

AU - Karimi, Seyed M

AU - Kasaeian, Amir

AU - Kassa, Dessalegn H

AU - Kassa, Getachew Mullu

AU - Kassa, Tesfaye Dessale

AU - Kassebaum, Nicholas

AU - Katikireddi, Srinivasa V

AU - kawakami, Norito

AU - Karyani, Ali Kazemi

AU - Keighobadi, Masoud M.

AU - Keiyoro, Peter Njenga

AU - Kemmer, Laura

AU - Kemp, Grant R.

AU - Kengne, Andre P

AU - Keren, Andre

AU - Khader, Yousef

AU - Khafaei, Behzad

AU - Khafaie, Morteza Abdullatif

AU - Khajavi, Alireza

AU - Khalil, Ibrahim

AU - Khan, E. A.

AU - Khan, Muhammad Shahzeb

AU - Khan, Muhammad Ali

AU - Khang, Young-Ho

AU - Khazaeipour, Zahra

AU - Khoja, Abdullah T

AU - Khosravi, A.

AU - Khosravi, Mohammad Hossein

AU - Ahmad Kiadaliri, Aliasghar

AU - Kiirithio, Daniel N.

AU - Kim, Cho-Il

AU - Kim, Daniel

AU - Kim, Pauline

AU - Kim, Young-Eun

AU - Kim, Yun J

AU - Kimokoti, Ruth

AU - KINFU, Yohannes

AU - Kisa, Adnan

AU - Kissimova-Skarbek, Katarzyna

AU - Kivimäki, Mika

AU - Knudsen, Ann K. S.

AU - Kocarnik, Jonathan M

AU - Kochhar, Sonali

AU - Kokubo, Yoshihiro

AU - Kolola, Tufa

AU - Kopec, Jacek A

AU - Kosen, Soewarta

AU - Kotsakis, Georgios A.

AU - Koul, P. A.

AU - Koyanagi, A.

AU - Kravchenko, Michael A

AU - Krishan, Kewal

AU - Krohn, Kristopher J.

AU - Defo, Barthelemy Kuate

AU - Bicer, B. Kucuk

AU - Kumar, G

AU - Kumar, Manasi

AU - Kyu, Hmwehmwe

AU - Lad, Deepesh P

AU - Lad, Sheetal D

AU - Lafranconi, Alessandra

AU - Lalloo, Ratilal

AU - Lallukka, Tea

AU - Al Lami, Faris Hasan

AU - Lansingh, Van C

AU - Latifi,, Arman

AU - Lau, Kathryn Mei-Ming

AU - Lazarus, Jeffrey V

AU - Leasher, Janet

AU - Ledesma, Jorge R

AU - Lee, Paul H

AU - Leigh, James

AU - Leung, Janni

AU - Levi, Miriam

AU - Lewycka, Sonia

AU - Li, Shanshan

AU - Li, Yichong

AU - Liao, Yu

AU - Liben, Misgan Legesse

AU - Lim, Lee-Ling

AU - Lim, Stephen

AU - Liu, Shiwei

AU - Lodha, Rakesh

AU - Looker, Katharine

AU - Lopez, Alan

AU - Lorkowski, Stefan

AU - Lotufo, Paulo

AU - Low, Nicola

AU - Lozano, Rafael

AU - Lucas, Timothy

AU - Lucchesi, Lydia R

AU - Lunevicius, Raimundas

AU - Lyons, Ronan

AU - Ma, Stefan

AU - Macarayan, Erlyn Rachelle King

AU - Mackay, Mark T

AU - Madotto, Fabiana

AU - Abd El Razek, H. Magdy

AU - Razek, Mohamed Magdy Abd El

AU - Maghavani, Dhaval P

AU - Mahotra, Narayan Bahadur

AU - Mai, Hue Thi

AU - Majdan, Marek

AU - Majdzadeh, Reza

AU - Majeed, Azeem

AU - Malekzadeh, Reza

AU - Malta, Deborah C

AU - Mamun, Abdullah A

AU - Manda, Ana-Laura

AU - Manguerra, Helena

AU - Manhertz, Treh

AU - Mansournia, Mohammad A.

AU - Mantovani, Lorenzo G.

AU - Mapoma, Christopher

AU - Maravilla, Joemer C

AU - MArcenes, wagner

AU - Marks, Ashley

AU - Martins-Melo, Francisco Rogerlândio

AU - Martopullo, Ira

AU - März, Winfried

AU - Marzan, M. B.

AU - Mashamba-Thompson, Tivani Phosa

AU - Massenburg, Benjamin Ballard

AU - Mathur, Manu Raj

AU - Matsushita, Kunihiro

AU - Maulik, Pallab K

AU - Mazidi, Mohsen

AU - McAlinden, Colm

PY - 2018/11/10

Y1 - 2018/11/10

N2 - Background: The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) includes a comprehensive assessment of incidence, prevalence, and years lived with disability (YLDs) for 354 causes in 195 countries and territories from 1990 to 2017. Previous GBD studies have shown how the decline of mortality rates from 1990 to 2016 has led to an increase in life expectancy, an ageing global population, and an expansion of the non-fatal burden of disease and injury. These studies have also shown how a substantial portion of the world's population experiences non-fatal health loss with considerable heterogeneity among different causes, locations, ages, and sexes. Ongoing objectives of the GBD study include increasing the level of estimation detail, improving analytical strategies, and increasing the amount of high-quality data. Methods: We estimated incidence and prevalence for 354 diseases and injuries and 3484 sequelae. We used an updated and extensive body of literature studies, survey data, surveillance data, inpatient admission records, outpatient visit records, and health insurance claims, and additionally used results from cause of death models to inform estimates using a total of 68 781 data sources. Newly available clinical data from India, Iran, Japan, Jordan, Nepal, China, Brazil, Norway, and Italy were incorporated, as well as updated claims data from the USA and new claims data from Taiwan (province of China) and Singapore. We used DisMod-MR 2.1, a Bayesian meta-regression tool, as the main method of estimation, ensuring consistency between rates of incidence, prevalence, remission, and cause of death for each condition. YLDs were estimated as the product of a prevalence estimate and a disability weight for health states of each mutually exclusive sequela, adjusted for comorbidity. We updated the Socio-demographic Index (SDI), a summary development indicator of income per capita, years of schooling, and total fertility rate. Additionally, we calculated differences between male and female YLDs to identify divergent trends across sexes. GBD 2017 complies with the Guidelines for Accurate and Transparent Health Estimates Reporting. Findings: Globally, for females, the causes with the greatest age-standardised prevalence were oral disorders, headache disorders, and haemoglobinopathies and haemolytic anaemias in both 1990 and 2017. For males, the causes with the greatest age-standardised prevalence were oral disorders, headache disorders, and tuberculosis including latent tuberculosis infection in both 1990 and 2017. In terms of YLDs, low back pain, headache disorders, and dietary iron deficiency were the leading Level 3 causes of YLD counts in 1990, whereas low back pain, headache disorders, and depressive disorders were the leading causes in 2017 for both sexes combined. All-cause age-standardised YLD rates decreased by 3·9% (95% uncertainty interval [UI] 3·1–4·6) from 1990 to 2017; however, the all-age YLD rate increased by 7·2% (6·0–8·4) while the total sum of global YLDs increased from 562 million (421–723) to 853 million (642–1100). The increases for males and females were similar, with increases in all-age YLD rates of 7·9% (6·6–9·2) for males and 6·5% (5·4–7·7) for females. We found significant differences between males and females in terms of age-standardised prevalence estimates for multiple causes. The causes with the greatest relative differences between sexes in 2017 included substance use disorders (3018 cases [95% UI 2782–3252] per 100 000 in males vs s1400 [1279–1524] per 100 000 in females), transport injuries (3322 [3082–3583] vs 2336 [2154–2535]), and self-harm and interpersonal violence (3265 [2943–3630] vs 5643 [5057–6302]). Interpretation: Global all-cause age-standardised YLD rates have improved only slightly over a period spanning nearly three decades. However, the magnitude of the non-fatal disease burden has expanded globally, with increasing numbers of people who have a wide spectrum of conditions. A subset of conditions has remained globally pervasive since 1990, whereas other conditions have displayed more dynamic trends, with different ages, sexes, and geographies across the globe experiencing varying burdens and trends of health loss. This study emphasises how global improvements in premature mortality for select conditions have led to older populations with complex and potentially expensive diseases, yet also highlights global achievements in certain domains of disease and injury. Funding: Bill & Melinda Gates Foundation.

AB - Background: The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) includes a comprehensive assessment of incidence, prevalence, and years lived with disability (YLDs) for 354 causes in 195 countries and territories from 1990 to 2017. Previous GBD studies have shown how the decline of mortality rates from 1990 to 2016 has led to an increase in life expectancy, an ageing global population, and an expansion of the non-fatal burden of disease and injury. These studies have also shown how a substantial portion of the world's population experiences non-fatal health loss with considerable heterogeneity among different causes, locations, ages, and sexes. Ongoing objectives of the GBD study include increasing the level of estimation detail, improving analytical strategies, and increasing the amount of high-quality data. Methods: We estimated incidence and prevalence for 354 diseases and injuries and 3484 sequelae. We used an updated and extensive body of literature studies, survey data, surveillance data, inpatient admission records, outpatient visit records, and health insurance claims, and additionally used results from cause of death models to inform estimates using a total of 68 781 data sources. Newly available clinical data from India, Iran, Japan, Jordan, Nepal, China, Brazil, Norway, and Italy were incorporated, as well as updated claims data from the USA and new claims data from Taiwan (province of China) and Singapore. We used DisMod-MR 2.1, a Bayesian meta-regression tool, as the main method of estimation, ensuring consistency between rates of incidence, prevalence, remission, and cause of death for each condition. YLDs were estimated as the product of a prevalence estimate and a disability weight for health states of each mutually exclusive sequela, adjusted for comorbidity. We updated the Socio-demographic Index (SDI), a summary development indicator of income per capita, years of schooling, and total fertility rate. Additionally, we calculated differences between male and female YLDs to identify divergent trends across sexes. GBD 2017 complies with the Guidelines for Accurate and Transparent Health Estimates Reporting. Findings: Globally, for females, the causes with the greatest age-standardised prevalence were oral disorders, headache disorders, and haemoglobinopathies and haemolytic anaemias in both 1990 and 2017. For males, the causes with the greatest age-standardised prevalence were oral disorders, headache disorders, and tuberculosis including latent tuberculosis infection in both 1990 and 2017. In terms of YLDs, low back pain, headache disorders, and dietary iron deficiency were the leading Level 3 causes of YLD counts in 1990, whereas low back pain, headache disorders, and depressive disorders were the leading causes in 2017 for both sexes combined. All-cause age-standardised YLD rates decreased by 3·9% (95% uncertainty interval [UI] 3·1–4·6) from 1990 to 2017; however, the all-age YLD rate increased by 7·2% (6·0–8·4) while the total sum of global YLDs increased from 562 million (421–723) to 853 million (642–1100). The increases for males and females were similar, with increases in all-age YLD rates of 7·9% (6·6–9·2) for males and 6·5% (5·4–7·7) for females. We found significant differences between males and females in terms of age-standardised prevalence estimates for multiple causes. The causes with the greatest relative differences between sexes in 2017 included substance use disorders (3018 cases [95% UI 2782–3252] per 100 000 in males vs s1400 [1279–1524] per 100 000 in females), transport injuries (3322 [3082–3583] vs 2336 [2154–2535]), and self-harm and interpersonal violence (3265 [2943–3630] vs 5643 [5057–6302]). Interpretation: Global all-cause age-standardised YLD rates have improved only slightly over a period spanning nearly three decades. However, the magnitude of the non-fatal disease burden has expanded globally, with increasing numbers of people who have a wide spectrum of conditions. A subset of conditions has remained globally pervasive since 1990, whereas other conditions have displayed more dynamic trends, with different ages, sexes, and geographies across the globe experiencing varying burdens and trends of health loss. This study emphasises how global improvements in premature mortality for select conditions have led to older populations with complex and potentially expensive diseases, yet also highlights global achievements in certain domains of disease and injury. Funding: Bill & Melinda Gates Foundation.

KW - Adolescent

KW - Adult

KW - Age Distribution

KW - Aged

KW - Aged, 80 and over

KW - Child

KW - Child, Preschool

KW - Disabled Persons/statistics & numerical data

KW - Female

KW - Global Burden of Disease/statistics & numerical data

KW - Global Health/statistics & numerical data

KW - Humans

KW - Incidence

KW - Infant

KW - Infant, Newborn

KW - Life Expectancy

KW - Male

KW - Middle Aged

KW - Morbidity/trends

KW - Prevalence

KW - Sex Distribution

KW - Socioeconomic Factors

KW - Wounds and Injuries/epidemiology

KW - Young Adult

UR - http://www.scopus.com/inward/record.url?scp=85056201393&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(18)32279-7

DO - 10.1016/S0140-6736(18)32279-7

M3 - Article

VL - 392

SP - 1789

EP - 1858

JO - Lancet

JF - Lancet

SN - 0140-6736

IS - 10159

ER -