Gut Balance, a synbiotic supplement, increases fecal Lactobacillus paracasei but has little effect on immunity in healthy physically active individuals

Nicholas P. West, David B Pyne, Allan W. Cripps, Claus T. Christophersen, Michael A. Conlon, Peter A. Fricker

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Synbiotic supplements, which contain multiple functional ingredients, may enhance the immune system more than the use of individual ingredients alone. A double blind active controlled parallel trial over a 21 d exercise training period was conducted to evaluate the effect of Gut Balance™, which contains Lactobacillus paracasei subsp. paracasei (L. casei 431®), Bifidobacterium animalis ssp. lactis (BB-12®), Lactobacillus acidophilus (LA-5®), Lactobacillus rhamnosus (LGG®), two prebiotics (raftiline and raftilose) and bovine whey derived lactoferrin and immunoglobulins with acacia gum on fecal microbiota, short chain fatty acids (SCFA), gut permeability, salivary lactoferrin and serum cytokines. All subjects randomized were included in the analysis. There was a 9-fold (1.2-fold to 64-fold; 95% confidence intervals p = 0.03) greater increase in fecal L. paracasei numbers with Gut Balance™ compared with acacia gum supplementation. Gut Balance™ was associated with a 50% (-12% to 72%; p = 0.02) smaller increase in the concentration of serum IL-16 in comparison to acacia gum from pre- to post-study. No substantial effects of either supplement were evident in fecal SCFA concentrations, measures of mucosal immunity or GI permeability. Clinical studies are now required to determine whether Gut Balance™ may exert beneficial GI health effects by increasing the recovery of fecal L. paracasei. Both supplements had little effect on immunity. Twenty two healthy physically active male subjects (mean age = 33.9 ± 6.5y) were randomly allocated to either daily prebiotic or synbiotic supplementation for 21 d. Saliva, blood, urine and fecal samples were collected pre-, mid and post-intervention. Participants recorded patterns of physical activity on a self-reported questionnaire.

Original languageEnglish
Pages (from-to)221-7
Number of pages7
JournalGut Microbes
Volume3
Issue number3
DOIs
Publication statusPublished - 11 May 2012
Externally publishedYes

Fingerprint

Synbiotics
Gum Arabic
Immunity
Prebiotics
Lactoferrin
Volatile Fatty Acids
Permeability
Interleukin-16
Lactobacillus rhamnosus
Lactobacillus acidophilus
Mucosal Immunity
Microbiota
Serum
Saliva
Immunoglobulins
Immune System
Urine
Confidence Intervals
Exercise
Cytokines

Cite this

West, Nicholas P. ; Pyne, David B ; Cripps, Allan W. ; Christophersen, Claus T. ; Conlon, Michael A. ; Fricker, Peter A. / Gut Balance, a synbiotic supplement, increases fecal Lactobacillus paracasei but has little effect on immunity in healthy physically active individuals. In: Gut Microbes. 2012 ; Vol. 3, No. 3. pp. 221-7.
@article{be3295efc6174fae81d20d5b50245044,
title = "Gut Balance, a synbiotic supplement, increases fecal Lactobacillus paracasei but has little effect on immunity in healthy physically active individuals",
abstract = "Synbiotic supplements, which contain multiple functional ingredients, may enhance the immune system more than the use of individual ingredients alone. A double blind active controlled parallel trial over a 21 d exercise training period was conducted to evaluate the effect of Gut Balance™, which contains Lactobacillus paracasei subsp. paracasei (L. casei 431{\circledR}), Bifidobacterium animalis ssp. lactis (BB-12{\circledR}), Lactobacillus acidophilus (LA-5{\circledR}), Lactobacillus rhamnosus (LGG{\circledR}), two prebiotics (raftiline and raftilose) and bovine whey derived lactoferrin and immunoglobulins with acacia gum on fecal microbiota, short chain fatty acids (SCFA), gut permeability, salivary lactoferrin and serum cytokines. All subjects randomized were included in the analysis. There was a 9-fold (1.2-fold to 64-fold; 95{\%} confidence intervals p = 0.03) greater increase in fecal L. paracasei numbers with Gut Balance™ compared with acacia gum supplementation. Gut Balance™ was associated with a 50{\%} (-12{\%} to 72{\%}; p = 0.02) smaller increase in the concentration of serum IL-16 in comparison to acacia gum from pre- to post-study. No substantial effects of either supplement were evident in fecal SCFA concentrations, measures of mucosal immunity or GI permeability. Clinical studies are now required to determine whether Gut Balance™ may exert beneficial GI health effects by increasing the recovery of fecal L. paracasei. Both supplements had little effect on immunity. Twenty two healthy physically active male subjects (mean age = 33.9 ± 6.5y) were randomly allocated to either daily prebiotic or synbiotic supplementation for 21 d. Saliva, blood, urine and fecal samples were collected pre-, mid and post-intervention. Participants recorded patterns of physical activity on a self-reported questionnaire.",
keywords = "Adult, Bacterial Load, Cytokines, Diet, Double-Blind Method, Fatty Acids, Feces, Gastrointestinal Tract, Humans, Lactobacillus, Lactoferrin, Male, Saliva, Serum, Synbiotics, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't",
author = "West, {Nicholas P.} and Pyne, {David B} and Cripps, {Allan W.} and Christophersen, {Claus T.} and Conlon, {Michael A.} and Fricker, {Peter A.}",
year = "2012",
month = "5",
day = "11",
doi = "10.4161/gmic.19579",
language = "English",
volume = "3",
pages = "221--7",
journal = "Gut Microbes",
issn = "1949-0976",
publisher = "Landes Bioscience",
number = "3",

}

Gut Balance, a synbiotic supplement, increases fecal Lactobacillus paracasei but has little effect on immunity in healthy physically active individuals. / West, Nicholas P.; Pyne, David B; Cripps, Allan W.; Christophersen, Claus T.; Conlon, Michael A.; Fricker, Peter A.

In: Gut Microbes, Vol. 3, No. 3, 11.05.2012, p. 221-7.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Gut Balance, a synbiotic supplement, increases fecal Lactobacillus paracasei but has little effect on immunity in healthy physically active individuals

AU - West, Nicholas P.

AU - Pyne, David B

AU - Cripps, Allan W.

AU - Christophersen, Claus T.

AU - Conlon, Michael A.

AU - Fricker, Peter A.

PY - 2012/5/11

Y1 - 2012/5/11

N2 - Synbiotic supplements, which contain multiple functional ingredients, may enhance the immune system more than the use of individual ingredients alone. A double blind active controlled parallel trial over a 21 d exercise training period was conducted to evaluate the effect of Gut Balance™, which contains Lactobacillus paracasei subsp. paracasei (L. casei 431®), Bifidobacterium animalis ssp. lactis (BB-12®), Lactobacillus acidophilus (LA-5®), Lactobacillus rhamnosus (LGG®), two prebiotics (raftiline and raftilose) and bovine whey derived lactoferrin and immunoglobulins with acacia gum on fecal microbiota, short chain fatty acids (SCFA), gut permeability, salivary lactoferrin and serum cytokines. All subjects randomized were included in the analysis. There was a 9-fold (1.2-fold to 64-fold; 95% confidence intervals p = 0.03) greater increase in fecal L. paracasei numbers with Gut Balance™ compared with acacia gum supplementation. Gut Balance™ was associated with a 50% (-12% to 72%; p = 0.02) smaller increase in the concentration of serum IL-16 in comparison to acacia gum from pre- to post-study. No substantial effects of either supplement were evident in fecal SCFA concentrations, measures of mucosal immunity or GI permeability. Clinical studies are now required to determine whether Gut Balance™ may exert beneficial GI health effects by increasing the recovery of fecal L. paracasei. Both supplements had little effect on immunity. Twenty two healthy physically active male subjects (mean age = 33.9 ± 6.5y) were randomly allocated to either daily prebiotic or synbiotic supplementation for 21 d. Saliva, blood, urine and fecal samples were collected pre-, mid and post-intervention. Participants recorded patterns of physical activity on a self-reported questionnaire.

AB - Synbiotic supplements, which contain multiple functional ingredients, may enhance the immune system more than the use of individual ingredients alone. A double blind active controlled parallel trial over a 21 d exercise training period was conducted to evaluate the effect of Gut Balance™, which contains Lactobacillus paracasei subsp. paracasei (L. casei 431®), Bifidobacterium animalis ssp. lactis (BB-12®), Lactobacillus acidophilus (LA-5®), Lactobacillus rhamnosus (LGG®), two prebiotics (raftiline and raftilose) and bovine whey derived lactoferrin and immunoglobulins with acacia gum on fecal microbiota, short chain fatty acids (SCFA), gut permeability, salivary lactoferrin and serum cytokines. All subjects randomized were included in the analysis. There was a 9-fold (1.2-fold to 64-fold; 95% confidence intervals p = 0.03) greater increase in fecal L. paracasei numbers with Gut Balance™ compared with acacia gum supplementation. Gut Balance™ was associated with a 50% (-12% to 72%; p = 0.02) smaller increase in the concentration of serum IL-16 in comparison to acacia gum from pre- to post-study. No substantial effects of either supplement were evident in fecal SCFA concentrations, measures of mucosal immunity or GI permeability. Clinical studies are now required to determine whether Gut Balance™ may exert beneficial GI health effects by increasing the recovery of fecal L. paracasei. Both supplements had little effect on immunity. Twenty two healthy physically active male subjects (mean age = 33.9 ± 6.5y) were randomly allocated to either daily prebiotic or synbiotic supplementation for 21 d. Saliva, blood, urine and fecal samples were collected pre-, mid and post-intervention. Participants recorded patterns of physical activity on a self-reported questionnaire.

KW - Adult

KW - Bacterial Load

KW - Cytokines

KW - Diet

KW - Double-Blind Method

KW - Fatty Acids

KW - Feces

KW - Gastrointestinal Tract

KW - Humans

KW - Lactobacillus

KW - Lactoferrin

KW - Male

KW - Saliva

KW - Serum

KW - Synbiotics

KW - Journal Article

KW - Randomized Controlled Trial

KW - Research Support, Non-U.S. Gov't

U2 - 10.4161/gmic.19579

DO - 10.4161/gmic.19579

M3 - Article

VL - 3

SP - 221

EP - 227

JO - Gut Microbes

JF - Gut Microbes

SN - 1949-0976

IS - 3

ER -