Heart rate variability and arterial oxygen saturation response during extreme normobaric hypoxia

Michal Botek, Jakub Krejci, Stefan De Smet, Ales Gaba, Andrew MCKUNE

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    Abstract

    The primary purpose of this study was to assess the response of autonomic cardiac activity and changes in the arterial oxygen saturation (SpO2) during normobaric hypoxia and subsequent recovery. Heart rate variability (HRV) and SpO2 were monitored in a supine position during hypoxia (FiO2=9.6%) for 10min, and normoxic recovery in 29 subjects. Spectral analysis of HRV quantified the autonomic cardiac activity by means of low frequency (LF) (0.05-0.15Hz) and high frequency (HF) (0.15-0.50Hz) power transformed by natural logarithm (Ln). Based on the SpO2 response to hypoxia, the subjects were divided into Resistant (RG, SpO2=80.8±7.0%) or Sensitive (SG, SpO2=67.2±2.9%) group. The SpO2 and vagal activity (LnHF) significantly decreased during hypoxia in both groups. A withdrawal in vagal activity was significantly greater in SG compared to RG. Moreover, only in SG, a relative increase in sympathetic modulation (Ln LF/HF) during hypoxia occurred. Correlations (r=-0.461, and r=0.595, both P<0.05) between δSpO2 (delta) and δLn LF/HF, and δLnHF were found. Based on results, it seems that SpO2 level could be an important factor that influences the autonomic cardiac response in hypoxia.

    Original languageEnglish
    Pages (from-to)40-45
    Number of pages6
    JournalAutonomic Neuroscience: Basic and Clinical
    Volume190
    Issue number10
    DOIs
    Publication statusPublished - 2015

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    Heart Rate
    Oxygen
    Supine Position
    Hypoxia

    Cite this

    Botek, Michal ; Krejci, Jakub ; De Smet, Stefan ; Gaba, Ales ; MCKUNE, Andrew. / Heart rate variability and arterial oxygen saturation response during extreme normobaric hypoxia. In: Autonomic Neuroscience: Basic and Clinical. 2015 ; Vol. 190, No. 10. pp. 40-45.
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    abstract = "The primary purpose of this study was to assess the response of autonomic cardiac activity and changes in the arterial oxygen saturation (SpO2) during normobaric hypoxia and subsequent recovery. Heart rate variability (HRV) and SpO2 were monitored in a supine position during hypoxia (FiO2=9.6{\%}) for 10min, and normoxic recovery in 29 subjects. Spectral analysis of HRV quantified the autonomic cardiac activity by means of low frequency (LF) (0.05-0.15Hz) and high frequency (HF) (0.15-0.50Hz) power transformed by natural logarithm (Ln). Based on the SpO2 response to hypoxia, the subjects were divided into Resistant (RG, SpO2=80.8±7.0{\%}) or Sensitive (SG, SpO2=67.2±2.9{\%}) group. The SpO2 and vagal activity (LnHF) significantly decreased during hypoxia in both groups. A withdrawal in vagal activity was significantly greater in SG compared to RG. Moreover, only in SG, a relative increase in sympathetic modulation (Ln LF/HF) during hypoxia occurred. Correlations (r=-0.461, and r=0.595, both P<0.05) between δSpO2 (delta) and δLn LF/HF, and δLnHF were found. Based on results, it seems that SpO2 level could be an important factor that influences the autonomic cardiac response in hypoxia.",
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    Heart rate variability and arterial oxygen saturation response during extreme normobaric hypoxia. / Botek, Michal; Krejci, Jakub; De Smet, Stefan; Gaba, Ales; MCKUNE, Andrew.

    In: Autonomic Neuroscience: Basic and Clinical, Vol. 190, No. 10, 2015, p. 40-45.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Heart rate variability and arterial oxygen saturation response during extreme normobaric hypoxia

    AU - Botek, Michal

    AU - Krejci, Jakub

    AU - De Smet, Stefan

    AU - Gaba, Ales

    AU - MCKUNE, Andrew

    PY - 2015

    Y1 - 2015

    N2 - The primary purpose of this study was to assess the response of autonomic cardiac activity and changes in the arterial oxygen saturation (SpO2) during normobaric hypoxia and subsequent recovery. Heart rate variability (HRV) and SpO2 were monitored in a supine position during hypoxia (FiO2=9.6%) for 10min, and normoxic recovery in 29 subjects. Spectral analysis of HRV quantified the autonomic cardiac activity by means of low frequency (LF) (0.05-0.15Hz) and high frequency (HF) (0.15-0.50Hz) power transformed by natural logarithm (Ln). Based on the SpO2 response to hypoxia, the subjects were divided into Resistant (RG, SpO2=80.8±7.0%) or Sensitive (SG, SpO2=67.2±2.9%) group. The SpO2 and vagal activity (LnHF) significantly decreased during hypoxia in both groups. A withdrawal in vagal activity was significantly greater in SG compared to RG. Moreover, only in SG, a relative increase in sympathetic modulation (Ln LF/HF) during hypoxia occurred. Correlations (r=-0.461, and r=0.595, both P<0.05) between δSpO2 (delta) and δLn LF/HF, and δLnHF were found. Based on results, it seems that SpO2 level could be an important factor that influences the autonomic cardiac response in hypoxia.

    AB - The primary purpose of this study was to assess the response of autonomic cardiac activity and changes in the arterial oxygen saturation (SpO2) during normobaric hypoxia and subsequent recovery. Heart rate variability (HRV) and SpO2 were monitored in a supine position during hypoxia (FiO2=9.6%) for 10min, and normoxic recovery in 29 subjects. Spectral analysis of HRV quantified the autonomic cardiac activity by means of low frequency (LF) (0.05-0.15Hz) and high frequency (HF) (0.15-0.50Hz) power transformed by natural logarithm (Ln). Based on the SpO2 response to hypoxia, the subjects were divided into Resistant (RG, SpO2=80.8±7.0%) or Sensitive (SG, SpO2=67.2±2.9%) group. The SpO2 and vagal activity (LnHF) significantly decreased during hypoxia in both groups. A withdrawal in vagal activity was significantly greater in SG compared to RG. Moreover, only in SG, a relative increase in sympathetic modulation (Ln LF/HF) during hypoxia occurred. Correlations (r=-0.461, and r=0.595, both P<0.05) between δSpO2 (delta) and δLn LF/HF, and δLnHF were found. Based on results, it seems that SpO2 level could be an important factor that influences the autonomic cardiac response in hypoxia.

    KW - Autonomic cardiac regulation

    KW - Desaturation

    KW - Simulated altitude

    KW - Sympathovagal balance

    KW - Vagal activity

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    M3 - Article

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    JF - Journal of the Autonomic Nervous System

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