Hepatitis C virus replication in cell culture

Michael Frese, Volker Lohmann, Thomas Pietschmann, Artur Kaul, Nicole Krieger, Jens Bukh, Ralf Bartenschlager

    Research output: A Conference proceeding or a Chapter in BookConference contributionpeer-review


    By using self-replicating hepatitis C virus (HCV) RNAs, it is now possible to investigate various aspects of the viral replication cycle in cell culture. Here, we describe the construction of subgenomic and genomic replicons which replicate to high levels in the human hepatoma cell line Huh-7. Furthermore, we report and discuss recent contributions from our laboratory which has provided a better understanding of (i) HCV particle formation, (ii) the mechanisms behind the cell culture-adaptation of HCV, and (iii) the innate immune response against HCV
    Original languageEnglish
    Title of host publicationTherapy for Viral Hepatitis and Prevention of Hepatocellular Carcinoma
    EditorsM Omata, K Okita
    Place of PublicationTokyo
    Number of pages15
    ISBN (Electronic)9784431539773
    ISBN (Print)9784431679752
    Publication statusPublished - 2004
    EventFirst JSH Single Topic Conference - , Japan
    Duration: 14 Nov 200215 Nov 2002


    ConferenceFirst JSH Single Topic Conference


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