Heritable Human Genome Editing: The Public Engagement Imperative

Eli Y. Adashi; Michael M. Burgess; Simon Burall; I. Glenn Cohen; Leonard M. Fleck; John Harris; Soren Holm; Cristina Lafont; Jonathan D. Moreno; Michael A. Neblo; Simon J. Niemeyer; Eugene J. Rowe; Dietram A. Scheufele; Paul F. Tetsa; Effy Vayena; Richard P. Watermeyer; Archon Fung

doi:10.1089/crispr.2020.0049

Heritable Human Genome Editing: The Public Engagement Imperative

Eli Y. Adashi, Michael M. Burgess, Simon Burall, I. Glenn Cohen, Leonard M. Fleck, John Harris, Soren Holm, Cristina Lafont, Jonathan D. Moreno, Michael A. Neblo, Simon J. Niemeyer, Eugene J. Rowe, Dietram A. Scheufele, Paul F. Tetsa, Effy Vayena, Richard P. Watermeyer, Archon Fung

Centre for Deliberative Democracy and Global Governance

Research output: Contribution to journal › Comment/debate › peer-review

19 Citations (Scopus)

Abstract

In the view of many, heritable human genome editing (HHGE) harbors the remedial potential of ridding the world of deadly genetic diseases. A Hippocratic obligation, if there ever was one, HHGE is widely viewed as a life-sustaining proposition. The national go/no-go decision regarding the implementation of HHGE, however, must not, in the collective view of the authors, proceed absent thorough public engagement. A comparable call for an "extensive societal dialogue"was recently issued by the International Commission on the Clinical Use of Human Germline Genome Editing. In this communication, the authors lay out the foundational principles undergirding the formation, modification, and evaluation of public opinion. It is against this backdrop that the societal decision to warrant or enjoin the clinical conduct of HHGE will doubtlessly transpire.

Original language	English
Pages (from-to)	434-439
Number of pages	6
Journal	CRISPR Journal
Volume	3
Issue number	6
DOIs	https://doi.org/10.1089/crispr.2020.0049
Publication status	Published - Dec 2020

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Adashi, E. Y., Burgess, M. M., Burall, S., Cohen, I. G., Fleck, L. M., Harris, J., Holm, S., Lafont, C., Moreno, J. D., Neblo, M. A., Niemeyer, S. J., Rowe, E. J., Scheufele, D. A., Tetsa, P. F., Vayena, E., Watermeyer, R. P., & Fung, A. (2020). Heritable Human Genome Editing: The Public Engagement Imperative. CRISPR Journal, 3(6), 434-439. https://doi.org/10.1089/crispr.2020.0049

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abstract = "In the view of many, heritable human genome editing (HHGE) harbors the remedial potential of ridding the world of deadly genetic diseases. A Hippocratic obligation, if there ever was one, HHGE is widely viewed as a life-sustaining proposition. The national go/no-go decision regarding the implementation of HHGE, however, must not, in the collective view of the authors, proceed absent thorough public engagement. A comparable call for an {"}extensive societal dialogue{"}was recently issued by the International Commission on the Clinical Use of Human Germline Genome Editing. In this communication, the authors lay out the foundational principles undergirding the formation, modification, and evaluation of public opinion. It is against this backdrop that the societal decision to warrant or enjoin the clinical conduct of HHGE will doubtlessly transpire.",

author = "Adashi, {Eli Y.} and Burgess, {Michael M.} and Simon Burall and Cohen, {I. Glenn} and Fleck, {Leonard M.} and John Harris and Soren Holm and Cristina Lafont and Moreno, {Jonathan D.} and Neblo, {Michael A.} and Niemeyer, {Simon J.} and Rowe, {Eugene J.} and Scheufele, {Dietram A.} and Tetsa, {Paul F.} and Effy Vayena and Watermeyer, {Richard P.} and Archon Fung",

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AU - Adashi, Eli Y.

AU - Burgess, Michael M.

AU - Burall, Simon

AU - Cohen, I. Glenn

AU - Fleck, Leonard M.

AU - Harris, John

AU - Holm, Soren

AU - Lafont, Cristina

AU - Moreno, Jonathan D.

AU - Neblo, Michael A.

AU - Niemeyer, Simon J.

AU - Rowe, Eugene J.

AU - Scheufele, Dietram A.

AU - Tetsa, Paul F.

AU - Vayena, Effy

AU - Watermeyer, Richard P.

AU - Fung, Archon

PY - 2020/12

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N2 - In the view of many, heritable human genome editing (HHGE) harbors the remedial potential of ridding the world of deadly genetic diseases. A Hippocratic obligation, if there ever was one, HHGE is widely viewed as a life-sustaining proposition. The national go/no-go decision regarding the implementation of HHGE, however, must not, in the collective view of the authors, proceed absent thorough public engagement. A comparable call for an "extensive societal dialogue"was recently issued by the International Commission on the Clinical Use of Human Germline Genome Editing. In this communication, the authors lay out the foundational principles undergirding the formation, modification, and evaluation of public opinion. It is against this backdrop that the societal decision to warrant or enjoin the clinical conduct of HHGE will doubtlessly transpire.

AB - In the view of many, heritable human genome editing (HHGE) harbors the remedial potential of ridding the world of deadly genetic diseases. A Hippocratic obligation, if there ever was one, HHGE is widely viewed as a life-sustaining proposition. The national go/no-go decision regarding the implementation of HHGE, however, must not, in the collective view of the authors, proceed absent thorough public engagement. A comparable call for an "extensive societal dialogue"was recently issued by the International Commission on the Clinical Use of Human Germline Genome Editing. In this communication, the authors lay out the foundational principles undergirding the formation, modification, and evaluation of public opinion. It is against this backdrop that the societal decision to warrant or enjoin the clinical conduct of HHGE will doubtlessly transpire.

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Heritable Human Genome Editing: The Public Engagement Imperative

Abstract

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