Hidden gems in the niche: A new approach to the study of spermatogonial stem cells

Kate L. Loveland; Eileen A. McLaughlin

doi:10.1038/aja.2012.150

Hidden gems in the niche: A new approach to the study of spermatogonial stem cells

Kate L. Loveland, Eileen A. McLaughlin

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Kanatsu-Shinohara and colleagues continue to reveal the secrets of the rare mammalian spermatogonial stem cells. Their most recent study offers a new approach by applying principles from hematopoietic stem cell research to demonstrate that cells which form a cobblestone-like underlay beneath testicular somatic cells in culture are spermatogonial stem cells. Utilization of mouse models and cell cultures shows how the chemokine, CXCL12, fits into the signalling cascade which governs the fate of these cells and hence is essential to male fertility.

Original language	English
Pages (from-to)	214-215
Number of pages	2
Journal	Asian Journal of Andrology
Volume	15
Issue number	2
DOIs	https://doi.org/10.1038/aja.2012.150
Publication status	Published - Mar 2013
Externally published	Yes

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10.1038/aja.2012.150

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739156/pdf/aja2012150a.pdf

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abstract = "Kanatsu-Shinohara and colleagues continue to reveal the secrets of the rare mammalian spermatogonial stem cells. Their most recent study offers a new approach by applying principles from hematopoietic stem cell research to demonstrate that cells which form a cobblestone-like underlay beneath testicular somatic cells in culture are spermatogonial stem cells. Utilization of mouse models and cell cultures shows how the chemokine, CXCL12, fits into the signalling cascade which governs the fate of these cells and hence is essential to male fertility.",

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AB - Kanatsu-Shinohara and colleagues continue to reveal the secrets of the rare mammalian spermatogonial stem cells. Their most recent study offers a new approach by applying principles from hematopoietic stem cell research to demonstrate that cells which form a cobblestone-like underlay beneath testicular somatic cells in culture are spermatogonial stem cells. Utilization of mouse models and cell cultures shows how the chemokine, CXCL12, fits into the signalling cascade which governs the fate of these cells and hence is essential to male fertility.

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Hidden gems in the niche: A new approach to the study of spermatogonial stem cells

Abstract

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