Hidden gems in the niche

A new approach to the study of spermatogonial stem cells

Kate L. Loveland, Eileen A. McLaughlin

Research output: Contribution to journalComment/debate


Kanatsu-Shinohara and colleagues continue to reveal the secrets of the rare mammalian spermatogonial stem cells. Their most recent study offers a new approach by applying principles from hematopoietic stem cell research to demonstrate that cells which form a cobblestone-like underlay beneath testicular somatic cells in culture are spermatogonial stem cells. Utilization of mouse models and cell cultures shows how the chemokine, CXCL12, fits into the signalling cascade which governs the fate of these cells and hence is essential to male fertility.
Original languageEnglish
Pages (from-to)214-215
Number of pages2
JournalAsian Journal of Andrology
Issue number2
Publication statusPublished - Mar 2013
Externally publishedYes


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