High prevalence of human parvovirus 4 infection in HBV and HCV infected individuals in Shanghai

Xuelian Yu, Jing Zhang, Liang Hong, Jiayu Wang, Zhengan Yuan, Xi Zhang, Reena Ghildyal

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Human parvovirus 4 (PARV4) has been detected in blood and diverse tissues samples from HIV/AIDS patients who are injecting drug users. Although B19 virus, the best characterized human parvovirus, has been shown to co-infect patients with hepatitis B or hepatitis C virus (HBV, HCV) infection, the association of PARV4 with HBV or HCV infections is still unknown.

The aim of this study was to characterise the association of viruses belonging to PARV4 genotype 1 and 2 with chronic HBV and HCV infection in Shanghai.

Serum samples of healthy controls, HCV infected subjects and HBV infected subjects were retrieved from Shanghai Center for Disease Control and Prevention (SCDC) Sample Bank. Parvovirus-specific nested-PCR was performed and results confirmed by sequencing. Sequences were compared with reference sequences obtained from Genbank to derive phylogeny trees.

The frequency of parvovirus molecular detection was 16–22%, 33% and 41% in healthy controls, HCV infected and HBV infected subjects respectively, with PARV4 being the only parvovirus detected. HCV infected and HBV infected subjects had a significantly higher PARV4 prevalence than the healthy population. No statistical difference was found in PARV4 prevalence between HBV or HCV infected subjects. PARV4 sequence divergence within study groups was similar in healthy subjects, HBV or HCV infected subjects.

Our data clearly demonstrate that PARV4 infection is strongly associated with HCV and HBV infection in Shanghai but may not cause increased disease severity
Original languageEnglish
Pages (from-to)e29474-e29478
Number of pages5
JournalPLoS One
Volume7
Issue number1
DOIs
Publication statusPublished - 2012

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Parvoviridae Infections
Parvovirus
Protoparvovirus
Viruses
China
infection
Disease control
Blood
Tissue
Pharmaceutical Preparations
Infection
Human Parvovirus B19
B19 virus
Nucleic Acid Databases
Centers for Disease Control and Prevention
Phylogeny
Centers for Disease Control and Prevention (U.S.)
Drug Users
Hepatitis B
Hepatitis C virus

Cite this

Yu, Xuelian ; Zhang, Jing ; Hong, Liang ; Wang, Jiayu ; Yuan, Zhengan ; Zhang, Xi ; Ghildyal, Reena. / High prevalence of human parvovirus 4 infection in HBV and HCV infected individuals in Shanghai. In: PLoS One. 2012 ; Vol. 7, No. 1. pp. e29474-e29478.
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abstract = "Human parvovirus 4 (PARV4) has been detected in blood and diverse tissues samples from HIV/AIDS patients who are injecting drug users. Although B19 virus, the best characterized human parvovirus, has been shown to co-infect patients with hepatitis B or hepatitis C virus (HBV, HCV) infection, the association of PARV4 with HBV or HCV infections is still unknown.The aim of this study was to characterise the association of viruses belonging to PARV4 genotype 1 and 2 with chronic HBV and HCV infection in Shanghai.Serum samples of healthy controls, HCV infected subjects and HBV infected subjects were retrieved from Shanghai Center for Disease Control and Prevention (SCDC) Sample Bank. Parvovirus-specific nested-PCR was performed and results confirmed by sequencing. Sequences were compared with reference sequences obtained from Genbank to derive phylogeny trees.The frequency of parvovirus molecular detection was 16–22{\%}, 33{\%} and 41{\%} in healthy controls, HCV infected and HBV infected subjects respectively, with PARV4 being the only parvovirus detected. HCV infected and HBV infected subjects had a significantly higher PARV4 prevalence than the healthy population. No statistical difference was found in PARV4 prevalence between HBV or HCV infected subjects. PARV4 sequence divergence within study groups was similar in healthy subjects, HBV or HCV infected subjects.Our data clearly demonstrate that PARV4 infection is strongly associated with HCV and HBV infection in Shanghai but may not cause increased disease severity",
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High prevalence of human parvovirus 4 infection in HBV and HCV infected individuals in Shanghai. / Yu, Xuelian; Zhang, Jing; Hong, Liang; Wang, Jiayu; Yuan, Zhengan; Zhang, Xi; Ghildyal, Reena.

In: PLoS One, Vol. 7, No. 1, 2012, p. e29474-e29478.

Research output: Contribution to journalArticle

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AU - Ghildyal, Reena

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