Histological and Immuno-histological investigation of the lymphoid tissue in normal and mycobacteria- affected specimens of the Rufous Hare-wallaby (Lagorchestes hirsutus).

Lauren Young, Rosemary MCFARLANE, Amy Slender, Elizabeth Deane

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The histology of the spleen, lymph nodes, Gut-associated lymphoid tissue (GALT) and Bronchus-associated lymphoid tissue (BALT) are described for samples collected opportunistically from healthy and mycobacteria-affected specimens of the endangered marsupial Lagorchestes hirsutus, the Rufous Hare-wallaby. The structural elements, organization and distribution of T and B lymphocytes determined by immunohistological techniques using species cross-reactive antibodies in the lymph nodes, spleen and GALT of this species demonstrated lymphoid cell distributions that were consistent with other marsupial and eutherian mammals. The tissues of animals identified as acid-fast positive displayed immunopathology consistent with the responses to intracellular bacteria displayed in some eutherian mammals and included the presence of focal lesions, giant cells in the lung and lymphoid aggregations situated adjacent to blood and airway vessels. This is the first study to describe the lymphoid tissue of this rare macropod species and the first to document the tissue bed response to mycobacteria.
Original languageEnglish
Pages (from-to)315-325
Number of pages10
JournalJournal of Anatomy
Volume202
Publication statusPublished - 2003
Externally publishedYes

Fingerprint

Macropodidae
Hares
Mycobacterium
Lymphoid Tissue
Marsupialia
Mammals
Metatheria
Spleen
marsupial
Lymph Nodes
lymph nodes
spleen
digestive system
mammals
immunopathology
Giant Cells
mammal
Bronchi
bronchi
animal tissues

Cite this

@article{5dcd22963abc48feaa3aebfe94c30693,
title = "Histological and Immuno-histological investigation of the lymphoid tissue in normal and mycobacteria- affected specimens of the Rufous Hare-wallaby (Lagorchestes hirsutus).",
abstract = "The histology of the spleen, lymph nodes, Gut-associated lymphoid tissue (GALT) and Bronchus-associated lymphoid tissue (BALT) are described for samples collected opportunistically from healthy and mycobacteria-affected specimens of the endangered marsupial Lagorchestes hirsutus, the Rufous Hare-wallaby. The structural elements, organization and distribution of T and B lymphocytes determined by immunohistological techniques using species cross-reactive antibodies in the lymph nodes, spleen and GALT of this species demonstrated lymphoid cell distributions that were consistent with other marsupial and eutherian mammals. The tissues of animals identified as acid-fast positive displayed immunopathology consistent with the responses to intracellular bacteria displayed in some eutherian mammals and included the presence of focal lesions, giant cells in the lung and lymphoid aggregations situated adjacent to blood and airway vessels. This is the first study to describe the lymphoid tissue of this rare macropod species and the first to document the tissue bed response to mycobacteria.",
author = "Lauren Young and Rosemary MCFARLANE and Amy Slender and Elizabeth Deane",
year = "2003",
language = "English",
volume = "202",
pages = "315--325",
journal = "Journal of Anatomy",
issn = "0021-8782",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Histological and Immuno-histological investigation of the lymphoid tissue in normal and mycobacteria- affected specimens of the Rufous Hare-wallaby (Lagorchestes hirsutus).

AU - Young, Lauren

AU - MCFARLANE, Rosemary

AU - Slender, Amy

AU - Deane, Elizabeth

PY - 2003

Y1 - 2003

N2 - The histology of the spleen, lymph nodes, Gut-associated lymphoid tissue (GALT) and Bronchus-associated lymphoid tissue (BALT) are described for samples collected opportunistically from healthy and mycobacteria-affected specimens of the endangered marsupial Lagorchestes hirsutus, the Rufous Hare-wallaby. The structural elements, organization and distribution of T and B lymphocytes determined by immunohistological techniques using species cross-reactive antibodies in the lymph nodes, spleen and GALT of this species demonstrated lymphoid cell distributions that were consistent with other marsupial and eutherian mammals. The tissues of animals identified as acid-fast positive displayed immunopathology consistent with the responses to intracellular bacteria displayed in some eutherian mammals and included the presence of focal lesions, giant cells in the lung and lymphoid aggregations situated adjacent to blood and airway vessels. This is the first study to describe the lymphoid tissue of this rare macropod species and the first to document the tissue bed response to mycobacteria.

AB - The histology of the spleen, lymph nodes, Gut-associated lymphoid tissue (GALT) and Bronchus-associated lymphoid tissue (BALT) are described for samples collected opportunistically from healthy and mycobacteria-affected specimens of the endangered marsupial Lagorchestes hirsutus, the Rufous Hare-wallaby. The structural elements, organization and distribution of T and B lymphocytes determined by immunohistological techniques using species cross-reactive antibodies in the lymph nodes, spleen and GALT of this species demonstrated lymphoid cell distributions that were consistent with other marsupial and eutherian mammals. The tissues of animals identified as acid-fast positive displayed immunopathology consistent with the responses to intracellular bacteria displayed in some eutherian mammals and included the presence of focal lesions, giant cells in the lung and lymphoid aggregations situated adjacent to blood and airway vessels. This is the first study to describe the lymphoid tissue of this rare macropod species and the first to document the tissue bed response to mycobacteria.

M3 - Article

VL - 202

SP - 315

EP - 325

JO - Journal of Anatomy

JF - Journal of Anatomy

SN - 0021-8782

ER -