Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 234-241 |
| Number of pages | 8 |
| Journal | Food and Chemical Toxicology |
| Volume | 72 |
| DOIs | |
| Publication status | Published - Oct 2014 |
Fingerprint
Cite this
}
Human pharmacokinetic study of tutin in honey : A plant-derived neurotoxin. / Fields, Barry; Reeve, John; Bartholomaeus, Andrew ; Mueller, Utz.
In: Food and Chemical Toxicology, Vol. 72, 10.2014, p. 234-241.Research output: Contribution to journal › Article
TY - JOUR
T1 - Human pharmacokinetic study of tutin in honey
T2 - A plant-derived neurotoxin
AU - Fields, Barry
AU - Reeve, John
AU - Bartholomaeus, Andrew
AU - Mueller, Utz
PY - 2014/10
Y1 - 2014/10
N2 - Over the last 150 years a number of people in New Zealand have been incapacitated, hospitalised, or died from eating honey contaminated with tutin, a plant-derived neurotoxin. A feature of the most recent poisoning incident in 2008 was the large variability in the onset time of clinical signs and symptoms of toxicity (0.5-17. h). To investigate the basis of this variability a pharmacokinetic study was undertaken in which 6 healthy males received a single oral dose of tutin-containing honey giving a tutin dose of 1.8. µg/kg body weight. The serum concentration-time curve for all volunteers exhibited two discrete peaks with the second and higher level occurring at approximately 15 h post-dose. Two subjects reported mild, transient headache at a time post-dose corresponding to maximum tutin concentrations. There were no other signs or symptoms typical of tutin intoxication such as nausea, vomiting, dizziness or seizures. Pharmacokinetic analysis using a two-site absorption model resulted in a good fit to the observed concentration data. A novel analytical method subsequently revealed the presence of glycoside conjugates of tutin in addition to unconjugated tutin in honey. These pharmacokinetic data will be important to better define a safe maximum tutin concentration in honey.
AB - Over the last 150 years a number of people in New Zealand have been incapacitated, hospitalised, or died from eating honey contaminated with tutin, a plant-derived neurotoxin. A feature of the most recent poisoning incident in 2008 was the large variability in the onset time of clinical signs and symptoms of toxicity (0.5-17. h). To investigate the basis of this variability a pharmacokinetic study was undertaken in which 6 healthy males received a single oral dose of tutin-containing honey giving a tutin dose of 1.8. µg/kg body weight. The serum concentration-time curve for all volunteers exhibited two discrete peaks with the second and higher level occurring at approximately 15 h post-dose. Two subjects reported mild, transient headache at a time post-dose corresponding to maximum tutin concentrations. There were no other signs or symptoms typical of tutin intoxication such as nausea, vomiting, dizziness or seizures. Pharmacokinetic analysis using a two-site absorption model resulted in a good fit to the observed concentration data. A novel analytical method subsequently revealed the presence of glycoside conjugates of tutin in addition to unconjugated tutin in honey. These pharmacokinetic data will be important to better define a safe maximum tutin concentration in honey.
KW - Coriaria arborea
KW - Glycosides
KW - Honey
KW - Neurotoxin
KW - Pharmacokinetics
KW - Tutin
UR - http://www.scopus.com/inward/record.url?scp=84907302598&partnerID=8YFLogxK
U2 - 10.1016/j.fct.2014.07.032
DO - 10.1016/j.fct.2014.07.032
M3 - Article
VL - 72
SP - 234
EP - 241
JO - Food and Cosmetics Toxicology
JF - Food and Cosmetics Toxicology
SN - 0278-6915
ER -