Human pharmacokinetic study of tutin in honey

A plant-derived neurotoxin

Barry Fields, John Reeve, Andrew Bartholomaeus, Utz Mueller

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Over the last 150 years a number of people in New Zealand have been incapacitated, hospitalised, or died from eating honey contaminated with tutin, a plant-derived neurotoxin. A feature of the most recent poisoning incident in 2008 was the large variability in the onset time of clinical signs and symptoms of toxicity (0.5-17. h). To investigate the basis of this variability a pharmacokinetic study was undertaken in which 6 healthy males received a single oral dose of tutin-containing honey giving a tutin dose of 1.8. µg/kg body weight. The serum concentration-time curve for all volunteers exhibited two discrete peaks with the second and higher level occurring at approximately 15 h post-dose. Two subjects reported mild, transient headache at a time post-dose corresponding to maximum tutin concentrations. There were no other signs or symptoms typical of tutin intoxication such as nausea, vomiting, dizziness or seizures. Pharmacokinetic analysis using a two-site absorption model resulted in a good fit to the observed concentration data. A novel analytical method subsequently revealed the presence of glycoside conjugates of tutin in addition to unconjugated tutin in honey. These pharmacokinetic data will be important to better define a safe maximum tutin concentration in honey.
Original languageEnglish
Pages (from-to)234-241
Number of pages8
JournalFood and Chemical Toxicology
Volume72
DOIs
Publication statusPublished - Oct 2014

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Pharmacokinetics
Honey
neurotoxins
Neurotoxins
honey
pharmacokinetics
dosage
poisoning
nausea
headache
vomiting
seizures
signs and symptoms (plants)
signs and symptoms (animals and humans)
Signs and Symptoms
volunteers
analytical methods
glycosides
mouth
ingestion

Cite this

Fields, Barry ; Reeve, John ; Bartholomaeus, Andrew ; Mueller, Utz. / Human pharmacokinetic study of tutin in honey : A plant-derived neurotoxin. In: Food and Chemical Toxicology. 2014 ; Vol. 72. pp. 234-241.
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Human pharmacokinetic study of tutin in honey : A plant-derived neurotoxin. / Fields, Barry; Reeve, John; Bartholomaeus, Andrew ; Mueller, Utz.

In: Food and Chemical Toxicology, Vol. 72, 10.2014, p. 234-241.

Research output: Contribution to journalArticle

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