TY - CHAP
T1 - Human respiratory syncytial virus
T2 - An introduction
AU - Jorquera, Patricia A.
AU - Anderson, Lydia
AU - Tripp, Ralph A.
N1 - Publisher Copyright:
© Springer Science+Business Media New York 2016.
PY - 2016
Y1 - 2016
N2 - Human respiratory syncytial virus (RSV) is understood to be a significant human pathogen in infants, young children, and the elderly and the immunocompromised. Over the last decade many important mechanisms contributing to RSV infection, replication, and disease pathogenesis have been revealed; however, there is still insufficient knowledge which has in part hampered vaccine development. Considerable information is accumulating regarding how RSV proteins modulate molecular signaling and immune responses to infection. Understanding how RSV interacts with its host is crucial to facilitate the development of safe and effective vaccines and therapeutic treatments. In this chapter, we provide a brief introduction into RSV replication, pathogenesis, and host immune response, and summarize the state of RSV vaccine and antiviral compounds in clinical stages of development. This chapter frames features of this book and the molecular methods used for understanding RSV interaction with the host.
AB - Human respiratory syncytial virus (RSV) is understood to be a significant human pathogen in infants, young children, and the elderly and the immunocompromised. Over the last decade many important mechanisms contributing to RSV infection, replication, and disease pathogenesis have been revealed; however, there is still insufficient knowledge which has in part hampered vaccine development. Considerable information is accumulating regarding how RSV proteins modulate molecular signaling and immune responses to infection. Understanding how RSV interacts with its host is crucial to facilitate the development of safe and effective vaccines and therapeutic treatments. In this chapter, we provide a brief introduction into RSV replication, pathogenesis, and host immune response, and summarize the state of RSV vaccine and antiviral compounds in clinical stages of development. This chapter frames features of this book and the molecular methods used for understanding RSV interaction with the host.
KW - Adaptive immune response
KW - Antiviral compounds
KW - Innate immune response
KW - Respiratory syncytial virus
KW - RSV proteins
KW - Vaccine
UR - http://www.scopus.com/inward/record.url?scp=84981489358&partnerID=8YFLogxK
U2 - 10.1007/978-1-4939-3687-8_1
DO - 10.1007/978-1-4939-3687-8_1
M3 - Other chapter contribution
C2 - 27464683
AN - SCOPUS:84981489358
SN - 9781493936854
T3 - Methods in Molecular Biology
SP - 1
EP - 12
BT - Methods in Molecular Biology
A2 - Tripp, Ralph A.
A2 - Jorquera, Patricia A.
PB - Springer
CY - New York
ER -
