Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: A feasibility study

Robert Rozenberg, Robert T. Mankowski, Luc J.C. Van Loon, Janneke G. Langendonk, Eric J.G. Sijbrands, Anton H. Van Den Meiracker, Henk J. Stam, Stephan F.E. Praet

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Abstract

Objective: The study investigated the feasibility and potential outcome measures during acute hyperoxia in type 2 diabetes patients (DM2). Methods: Eleven DM2 patients (7 men and 4 women) were included in the study. The patients cycled (30 min at 20 % Wmax) whilst breathing three different supplemental oxygen flows (SOF, 5, 10, 15 L min-1). During hyperoxic exercise, arterial blood gases and intra-arterial blood pressure measurements were obtained. Results: Arterial pO2 levels increased significantly (ANOVA, p < 0.05) with SOF: 13.9 ± 1.2 (0 L min-1); 18.5 ± 1.5 (5 L min-1); 21.7 ± 1.7 (10 L min-1); 24.0 ± 2.3 (15 L min-1). Heart rate (HR) and pH increased significantly after terminating administration of hyperoxic air. Conclusions: An SOF of 15 L min-1 appears to be more effective than 5 or 10 L min-1. Moreover, HR, blood pressure, blood lactate and pH are not recommended as primary outcome measures.

Original languageEnglish
Article number1
Pages (from-to)1-8
Number of pages8
JournalEuropean Journal of Medical Research
Volume21
Issue number1
DOIs
Publication statusPublished - 8 Jan 2016
Externally publishedYes

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