TY - JOUR
T1 - Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients
T2 - A feasibility study
AU - Rozenberg, Robert
AU - Mankowski, Robert T.
AU - Van Loon, Luc J.C.
AU - Langendonk, Janneke G.
AU - Sijbrands, Eric J.G.
AU - Van Den Meiracker, Anton H.
AU - Stam, Henk J.
AU - Praet, Stephan F.E.
N1 - Funding Information:
This study was supported by the Dutch Research Foundation 2008.11.007. The authors would like to thank Ashraf Fagirzada and Mery Arevalo de Weever for their assistance with patient recruitment and experimental procedures.
Publisher Copyright:
© 2016 Rozenberg et al.
PY - 2016/1/8
Y1 - 2016/1/8
N2 - Objective: The study investigated the feasibility and potential outcome measures during acute hyperoxia in type 2 diabetes patients (DM2). Methods: Eleven DM2 patients (7 men and 4 women) were included in the study. The patients cycled (30 min at 20 % Wmax) whilst breathing three different supplemental oxygen flows (SOF, 5, 10, 15 L min-1). During hyperoxic exercise, arterial blood gases and intra-arterial blood pressure measurements were obtained. Results: Arterial pO2 levels increased significantly (ANOVA, p < 0.05) with SOF: 13.9 ± 1.2 (0 L min-1); 18.5 ± 1.5 (5 L min-1); 21.7 ± 1.7 (10 L min-1); 24.0 ± 2.3 (15 L min-1). Heart rate (HR) and pH increased significantly after terminating administration of hyperoxic air. Conclusions: An SOF of 15 L min-1 appears to be more effective than 5 or 10 L min-1. Moreover, HR, blood pressure, blood lactate and pH are not recommended as primary outcome measures.
AB - Objective: The study investigated the feasibility and potential outcome measures during acute hyperoxia in type 2 diabetes patients (DM2). Methods: Eleven DM2 patients (7 men and 4 women) were included in the study. The patients cycled (30 min at 20 % Wmax) whilst breathing three different supplemental oxygen flows (SOF, 5, 10, 15 L min-1). During hyperoxic exercise, arterial blood gases and intra-arterial blood pressure measurements were obtained. Results: Arterial pO2 levels increased significantly (ANOVA, p < 0.05) with SOF: 13.9 ± 1.2 (0 L min-1); 18.5 ± 1.5 (5 L min-1); 21.7 ± 1.7 (10 L min-1); 24.0 ± 2.3 (15 L min-1). Heart rate (HR) and pH increased significantly after terminating administration of hyperoxic air. Conclusions: An SOF of 15 L min-1 appears to be more effective than 5 or 10 L min-1. Moreover, HR, blood pressure, blood lactate and pH are not recommended as primary outcome measures.
KW - Diabetes type 2
KW - Dose
KW - Exercise
KW - Hyperoxia
KW - Oxygen
UR - http://www.scopus.com/inward/record.url?scp=84953252506&partnerID=8YFLogxK
U2 - 10.1186/s40001-015-0194-5
DO - 10.1186/s40001-015-0194-5
M3 - Article
C2 - 26744210
AN - SCOPUS:84953252506
SN - 2047-783X
VL - 21
SP - 1
EP - 8
JO - European Journal of Medical Research
JF - European Journal of Medical Research
IS - 1
M1 - 1
ER -
