Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: A feasibility study

Robert Rozenberg; Robert T. Mankowski; Luc J.C. Van Loon; Janneke G. Langendonk; Eric J.G. Sijbrands; Anton H. Van Den Meiracker; Henk J. Stam; Stephan F.E. Praet

doi:10.1186/s40001-015-0194-5

Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: A feasibility study

Robert Rozenberg
, Robert T. Mankowski
, Luc J.C. Van Loon
, Janneke G. Langendonk
, Eric J.G. Sijbrands
, Anton H. Van Den Meiracker
, Henk J. Stam
, Stephan F.E. Praet

Research output: Contribution to journal › Article › peer-review

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Abstract

Objective: The study investigated the feasibility and potential outcome measures during acute hyperoxia in type 2 diabetes patients (DM2). Methods: Eleven DM2 patients (7 men and 4 women) were included in the study. The patients cycled (30 min at 20 % W_max) whilst breathing three different supplemental oxygen flows (SOF, 5, 10, 15 L min^-1). During hyperoxic exercise, arterial blood gases and intra-arterial blood pressure measurements were obtained. Results: Arterial pO₂ levels increased significantly (ANOVA, p < 0.05) with SOF: 13.9 ± 1.2 (0 L min^-1); 18.5 ± 1.5 (5 L min^-1); 21.7 ± 1.7 (10 L min^-1); 24.0 ± 2.3 (15 L min^-1). Heart rate (HR) and pH increased significantly after terminating administration of hyperoxic air. Conclusions: An SOF of 15 L min^-1 appears to be more effective than 5 or 10 L min^-1. Moreover, HR, blood pressure, blood lactate and pH are not recommended as primary outcome measures.

Original language	English
Article number	1
Pages (from-to)	1-8
Number of pages	8
Journal	European Journal of Medical Research
Volume	21
Issue number	1
DOIs	https://doi.org/10.1186/s40001-015-0194-5
Publication status	Published - 8 Jan 2016
Externally published	Yes

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Rozenberg, R., Mankowski, R. T., Van Loon, L. J. C., Langendonk, J. G., Sijbrands, E. J. G., Van Den Meiracker, A. H., Stam, H. J., & Praet, S. F. E. (2016). Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: A feasibility study. European Journal of Medical Research, 21(1), 1-8. Article 1. https://doi.org/10.1186/s40001-015-0194-5

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title = "Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: A feasibility study",

abstract = "Objective: The study investigated the feasibility and potential outcome measures during acute hyperoxia in type 2 diabetes patients (DM2). Methods: Eleven DM2 patients (7 men and 4 women) were included in the study. The patients cycled (30 min at 20 \% Wmax) whilst breathing three different supplemental oxygen flows (SOF, 5, 10, 15 L min-1). During hyperoxic exercise, arterial blood gases and intra-arterial blood pressure measurements were obtained. Results: Arterial pO2 levels increased significantly (ANOVA, p < 0.05) with SOF: 13.9 ± 1.2 (0 L min-1); 18.5 ± 1.5 (5 L min-1); 21.7 ± 1.7 (10 L min-1); 24.0 ± 2.3 (15 L min-1). Heart rate (HR) and pH increased significantly after terminating administration of hyperoxic air. Conclusions: An SOF of 15 L min-1 appears to be more effective than 5 or 10 L min-1. Moreover, HR, blood pressure, blood lactate and pH are not recommended as primary outcome measures.",

keywords = "Diabetes type 2, Dose, Exercise, Hyperoxia, Oxygen",

author = "Robert Rozenberg and Mankowski, \{Robert T.\} and \{Van Loon\}, \{Luc J.C.\} and Langendonk, \{Janneke G.\} and Sijbrands, \{Eric J.G.\} and \{Van Den Meiracker\}, \{Anton H.\} and Stam, \{Henk J.\} and Praet, \{Stephan F.E.\}",

note = "Funding Information: This study was supported by the Dutch Research Foundation 2008.11.007. The authors would like to thank Ashraf Fagirzada and Mery Arevalo de Weever for their assistance with patient recruitment and experimental procedures. Publisher Copyright: {\textcopyright} 2016 Rozenberg et al.",

year = "2016",

month = jan,

day = "8",

doi = "10.1186/s40001-015-0194-5",

language = "English",

volume = "21",

pages = "1--8",

journal = "European Journal of Medical Research",

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T1 - Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients

T2 - A feasibility study

AU - Rozenberg, Robert

AU - Mankowski, Robert T.

AU - Van Loon, Luc J.C.

AU - Langendonk, Janneke G.

AU - Sijbrands, Eric J.G.

AU - Van Den Meiracker, Anton H.

AU - Stam, Henk J.

AU - Praet, Stephan F.E.

N1 - Funding Information: This study was supported by the Dutch Research Foundation 2008.11.007. The authors would like to thank Ashraf Fagirzada and Mery Arevalo de Weever for their assistance with patient recruitment and experimental procedures. Publisher Copyright: © 2016 Rozenberg et al.

PY - 2016/1/8

Y1 - 2016/1/8

N2 - Objective: The study investigated the feasibility and potential outcome measures during acute hyperoxia in type 2 diabetes patients (DM2). Methods: Eleven DM2 patients (7 men and 4 women) were included in the study. The patients cycled (30 min at 20 % Wmax) whilst breathing three different supplemental oxygen flows (SOF, 5, 10, 15 L min-1). During hyperoxic exercise, arterial blood gases and intra-arterial blood pressure measurements were obtained. Results: Arterial pO2 levels increased significantly (ANOVA, p < 0.05) with SOF: 13.9 ± 1.2 (0 L min-1); 18.5 ± 1.5 (5 L min-1); 21.7 ± 1.7 (10 L min-1); 24.0 ± 2.3 (15 L min-1). Heart rate (HR) and pH increased significantly after terminating administration of hyperoxic air. Conclusions: An SOF of 15 L min-1 appears to be more effective than 5 or 10 L min-1. Moreover, HR, blood pressure, blood lactate and pH are not recommended as primary outcome measures.

AB - Objective: The study investigated the feasibility and potential outcome measures during acute hyperoxia in type 2 diabetes patients (DM2). Methods: Eleven DM2 patients (7 men and 4 women) were included in the study. The patients cycled (30 min at 20 % Wmax) whilst breathing three different supplemental oxygen flows (SOF, 5, 10, 15 L min-1). During hyperoxic exercise, arterial blood gases and intra-arterial blood pressure measurements were obtained. Results: Arterial pO2 levels increased significantly (ANOVA, p < 0.05) with SOF: 13.9 ± 1.2 (0 L min-1); 18.5 ± 1.5 (5 L min-1); 21.7 ± 1.7 (10 L min-1); 24.0 ± 2.3 (15 L min-1). Heart rate (HR) and pH increased significantly after terminating administration of hyperoxic air. Conclusions: An SOF of 15 L min-1 appears to be more effective than 5 or 10 L min-1. Moreover, HR, blood pressure, blood lactate and pH are not recommended as primary outcome measures.

KW - Diabetes type 2

KW - Dose

KW - Exercise

KW - Hyperoxia

KW - Oxygen

UR - https://www.scopus.com/pages/publications/84953252506

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DO - 10.1186/s40001-015-0194-5

M3 - Article

C2 - 26744210

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VL - 21

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JO - European Journal of Medical Research

JF - European Journal of Medical Research

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M1 - 1

ER -

Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: A feasibility study

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