Identification of natural killer cell receptor clusters in the platypus genome reveals an expansion of C-type lectin genes

Emily Wong, Claire Sanderson, Janine Deakin, Camilla Whittington, Anthony Papenfuss, Katherine Belov

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    Natural killer (NK) cell receptors belong to two unrelated, but functionally analogous gene families: the immunoglobulin superfamily, situated in the leukocyte receptor complex (LRC) and the C-type lectin superfamily, located in the natural killer complex (NKC). Here, we describe the largest NK receptor gene expansion seen to date. We identified 213 putative C-type lectin NK receptor homologs in the genome of the platypus. Many have arisen as the result of a lineage-specific expansion. Orthologs of OLR1, CD69, KLRE, CLEC12B, and CLEC16p genes were also identified. The NKC is split into at least two regions of the genome: 34 genes map to chromosome 7, two map to a small autosome, and the remainder are unanchored in the current genome assembly. No NK receptor genes from the LRC were identified. The massive C-type lectin expansion and lack of Ig-domain-containing NK receptors represents the most extreme polarization of NK receptors found to date. We have used this new data from platypus to trace the possible evolutionary history of the NK receptor clusters.
    Original languageEnglish
    Pages (from-to)565-579
    Number of pages15
    JournalImmunogenetics
    Volume61
    DOIs
    Publication statusPublished - 2009

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    Platypus
    Natural Killer Cell Receptors
    C-Type Lectins
    Genome
    Genes
    Leukocytes
    Immunoglobulin Genes
    Chromosomes, Human, Pair 7
    Natural History

    Cite this

    Wong, Emily ; Sanderson, Claire ; Deakin, Janine ; Whittington, Camilla ; Papenfuss, Anthony ; Belov, Katherine. / Identification of natural killer cell receptor clusters in the platypus genome reveals an expansion of C-type lectin genes. In: Immunogenetics. 2009 ; Vol. 61. pp. 565-579.
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    abstract = "Natural killer (NK) cell receptors belong to two unrelated, but functionally analogous gene families: the immunoglobulin superfamily, situated in the leukocyte receptor complex (LRC) and the C-type lectin superfamily, located in the natural killer complex (NKC). Here, we describe the largest NK receptor gene expansion seen to date. We identified 213 putative C-type lectin NK receptor homologs in the genome of the platypus. Many have arisen as the result of a lineage-specific expansion. Orthologs of OLR1, CD69, KLRE, CLEC12B, and CLEC16p genes were also identified. The NKC is split into at least two regions of the genome: 34 genes map to chromosome 7, two map to a small autosome, and the remainder are unanchored in the current genome assembly. No NK receptor genes from the LRC were identified. The massive C-type lectin expansion and lack of Ig-domain-containing NK receptors represents the most extreme polarization of NK receptors found to date. We have used this new data from platypus to trace the possible evolutionary history of the NK receptor clusters.",
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    Identification of natural killer cell receptor clusters in the platypus genome reveals an expansion of C-type lectin genes. / Wong, Emily; Sanderson, Claire; Deakin, Janine; Whittington, Camilla; Papenfuss, Anthony; Belov, Katherine.

    In: Immunogenetics, Vol. 61, 2009, p. 565-579.

    Research output: Contribution to journalArticle

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    AU - Belov, Katherine

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    AB - Natural killer (NK) cell receptors belong to two unrelated, but functionally analogous gene families: the immunoglobulin superfamily, situated in the leukocyte receptor complex (LRC) and the C-type lectin superfamily, located in the natural killer complex (NKC). Here, we describe the largest NK receptor gene expansion seen to date. We identified 213 putative C-type lectin NK receptor homologs in the genome of the platypus. Many have arisen as the result of a lineage-specific expansion. Orthologs of OLR1, CD69, KLRE, CLEC12B, and CLEC16p genes were also identified. The NKC is split into at least two regions of the genome: 34 genes map to chromosome 7, two map to a small autosome, and the remainder are unanchored in the current genome assembly. No NK receptor genes from the LRC were identified. The massive C-type lectin expansion and lack of Ig-domain-containing NK receptors represents the most extreme polarization of NK receptors found to date. We have used this new data from platypus to trace the possible evolutionary history of the NK receptor clusters.

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