Abstract
Relaxin immunoreactivity has been found in samples of human follicular fluid collected from artificially stimulated pre-ovulatory follicles. The crude extract caused a reduction in the height of the contractions in a rat uterine strip bioassay. The reactive material eluted from Sephadex G50 in two major peaks. The first contained ̃ 60% of the immunoreactivity and had an elution position corresponding to that of porcine relaxin, indicating a mol. wt of ̃ 6000 daltons. The second peak was of a lower mol. wt, but its exact size and significance are unknown. A possible role for relaxin in the process of follicular rupture is suggested.
| Original language | English |
|---|---|
| Pages (from-to) | 515-517 |
| Number of pages | 3 |
| Journal | Human Reproduction |
| Volume | 1 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 1 Dec 1986 |
| Externally published | Yes |
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Identification of relaxin immunoreactivity in human follicular fluid. / Wathes, D. Claire; Wardle, Peter G.; Rees, Jackie M.; Mitchell, Josephine D.; Mclaughlin, Eileen A.; Hull, Michael G.R.; Porter, David G.
In: Human Reproduction, Vol. 1, No. 8, 01.12.1986, p. 515-517.Research output: Contribution to journal › Article
TY - JOUR
T1 - Identification of relaxin immunoreactivity in human follicular fluid
AU - Wathes, D. Claire
AU - Wardle, Peter G.
AU - Rees, Jackie M.
AU - Mitchell, Josephine D.
AU - Mclaughlin, Eileen A.
AU - Hull, Michael G.R.
AU - Porter, David G.
PY - 1986/12/1
Y1 - 1986/12/1
N2 - Relaxin immunoreactivity has been found in samples of human follicular fluid collected from artificially stimulated pre-ovulatory follicles. The crude extract caused a reduction in the height of the contractions in a rat uterine strip bioassay. The reactive material eluted from Sephadex G50 in two major peaks. The first contained ̃ 60% of the immunoreactivity and had an elution position corresponding to that of porcine relaxin, indicating a mol. wt of ̃ 6000 daltons. The second peak was of a lower mol. wt, but its exact size and significance are unknown. A possible role for relaxin in the process of follicular rupture is suggested.
AB - Relaxin immunoreactivity has been found in samples of human follicular fluid collected from artificially stimulated pre-ovulatory follicles. The crude extract caused a reduction in the height of the contractions in a rat uterine strip bioassay. The reactive material eluted from Sephadex G50 in two major peaks. The first contained ̃ 60% of the immunoreactivity and had an elution position corresponding to that of porcine relaxin, indicating a mol. wt of ̃ 6000 daltons. The second peak was of a lower mol. wt, but its exact size and significance are unknown. A possible role for relaxin in the process of follicular rupture is suggested.
KW - follicular fluid
KW - hair follicle
KW - ovarian follicle
KW - relaxin
KW - rupture
KW - suidae
KW - rats
KW - uterus
KW - ovulatory cycle
UR - http://www.scopus.com/inward/record.url?scp=0022979349&partnerID=8YFLogxK
U2 - 10.1093/oxfordjournals.humrep.a136465
DO - 10.1093/oxfordjournals.humrep.a136465
M3 - Article
VL - 1
SP - 515
EP - 517
JO - Human Reproduction
JF - Human Reproduction
SN - 0268-1161
IS - 8
ER -