Identification of relaxin immunoreactivity in human follicular fluid

D. Claire Wathes, Peter G. Wardle, Jackie M. Rees, Josephine D. Mitchell, Eileen A. Mclaughlin, Michael G.R. Hull, David G. Porter

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12 Citations (Scopus)

Abstract

Relaxin immunoreactivity has been found in samples of human follicular fluid collected from artificially stimulated pre-ovulatory follicles. The crude extract caused a reduction in the height of the contractions in a rat uterine strip bioassay. The reactive material eluted from Sephadex G50 in two major peaks. The first contained ̃ 60% of the immunoreactivity and had an elution position corresponding to that of porcine relaxin, indicating a mol. wt of ̃ 6000 daltons. The second peak was of a lower mol. wt, but its exact size and significance are unknown. A possible role for relaxin in the process of follicular rupture is suggested.

Original languageEnglish
Pages (from-to)515-517
Number of pages3
JournalHuman Reproduction
Volume1
Issue number8
DOIs
Publication statusPublished - 1 Dec 1986
Externally publishedYes

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    Wathes, D. C., Wardle, P. G., Rees, J. M., Mitchell, J. D., Mclaughlin, E. A., Hull, M. G. R., & Porter, D. G. (1986). Identification of relaxin immunoreactivity in human follicular fluid. Human Reproduction, 1(8), 515-517. https://doi.org/10.1093/oxfordjournals.humrep.a136465