Identification of relaxin immunoreactivity in human follicular fluid

D. Claire Wathes, Peter G. Wardle, Jackie M. Rees, Josephine D. Mitchell, Eileen A. Mclaughlin, Michael G.R. Hull, David G. Porter

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Relaxin immunoreactivity has been found in samples of human follicular fluid collected from artificially stimulated pre-ovulatory follicles. The crude extract caused a reduction in the height of the contractions in a rat uterine strip bioassay. The reactive material eluted from Sephadex G50 in two major peaks. The first contained ̃ 60% of the immunoreactivity and had an elution position corresponding to that of porcine relaxin, indicating a mol. wt of ̃ 6000 daltons. The second peak was of a lower mol. wt, but its exact size and significance are unknown. A possible role for relaxin in the process of follicular rupture is suggested.

Original languageEnglish
Pages (from-to)515-517
Number of pages3
JournalHuman Reproduction
Issue number8
Publication statusPublished - 1 Dec 1986
Externally publishedYes


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