IGF-1 and its receptor in esophageal cancer: Association with adenocarcinoma and visceral obesity

Suzanne Doyle, Claire Donohoe, Stephen Finn, Julia Howard, Fiona LITHANDER, John Reynolds, Graham Pidgeon, Joanne Lysaght

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The insulin-like growth factor (IGF) pathway and visceral obesity have been independently linked with esophageal cancer. This study aimed to delineate the differential and interlinked role of visceral obesity and the IGF-1 system in esophageal adenocarcinoma and esophageal squamous-cell carcinoma (SCC). Methods: IGF-1 receptor (IGF-1R) mRNA and protein were examined in esophageal SCC (KYSE 410, OE21) and esophageal adenocarcinoma (OE19, OE33) cell lines by western blotting.
Original languageEnglish
Pages (from-to)196-204
Number of pages9
JournalAmerican Journal of Gastroenterology
Volume107
Issue number2
DOIs
Publication statusPublished - 2012
Externally publishedYes

    Fingerprint

Cite this

Doyle, S., Donohoe, C., Finn, S., Howard, J., LITHANDER, F., Reynolds, J., ... Lysaght, J. (2012). IGF-1 and its receptor in esophageal cancer: Association with adenocarcinoma and visceral obesity. American Journal of Gastroenterology, 107(2), 196-204. https://doi.org/10.1038/ajg.2011.417