IGF-1 and its receptor in esophageal cancer: Association with adenocarcinoma and visceral obesity

Suzanne Doyle; Claire Donohoe; Stephen Finn; Julia Howard; Fiona LITHANDER; John Reynolds; Graham Pidgeon; Joanne Lysaght

doi:10.1038/ajg.2011.417

IGF-1 and its receptor in esophageal cancer: Association with adenocarcinoma and visceral obesity

Suzanne Doyle, Claire Donohoe, Stephen Finn, Julia Howard, Fiona LITHANDER, John Reynolds, Graham Pidgeon, Joanne Lysaght

Research output: Contribution to journal › Article › peer-review

91 Citations (Scopus)

Abstract

The insulin-like growth factor (IGF) pathway and visceral obesity have been independently linked with esophageal cancer. This study aimed to delineate the differential and interlinked role of visceral obesity and the IGF-1 system in esophageal adenocarcinoma and esophageal squamous-cell carcinoma (SCC). Methods: IGF-1 receptor (IGF-1R) mRNA and protein were examined in esophageal SCC (KYSE 410, OE21) and esophageal adenocarcinoma (OE19, OE33) cell lines by western blotting.

Original language	English
Pages (from-to)	196-204
Number of pages	9
Journal	American Journal of Gastroenterology
Volume	107
Issue number	2
DOIs	https://doi.org/10.1038/ajg.2011.417
Publication status	Published - 2012
Externally published	Yes

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10.1038/ajg.2011.417

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abstract = "The insulin-like growth factor (IGF) pathway and visceral obesity have been independently linked with esophageal cancer. This study aimed to delineate the differential and interlinked role of visceral obesity and the IGF-1 system in esophageal adenocarcinoma and esophageal squamous-cell carcinoma (SCC). Methods: IGF-1 receptor (IGF-1R) mRNA and protein were examined in esophageal SCC (KYSE 410, OE21) and esophageal adenocarcinoma (OE19, OE33) cell lines by western blotting.",

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AU - Doyle, Suzanne

AU - Donohoe, Claire

AU - Finn, Stephen

AU - Howard, Julia

AU - LITHANDER, Fiona

AU - Reynolds, John

AU - Pidgeon, Graham

AU - Lysaght, Joanne

PY - 2012

Y1 - 2012

N2 - The insulin-like growth factor (IGF) pathway and visceral obesity have been independently linked with esophageal cancer. This study aimed to delineate the differential and interlinked role of visceral obesity and the IGF-1 system in esophageal adenocarcinoma and esophageal squamous-cell carcinoma (SCC). Methods: IGF-1 receptor (IGF-1R) mRNA and protein were examined in esophageal SCC (KYSE 410, OE21) and esophageal adenocarcinoma (OE19, OE33) cell lines by western blotting.

AB - The insulin-like growth factor (IGF) pathway and visceral obesity have been independently linked with esophageal cancer. This study aimed to delineate the differential and interlinked role of visceral obesity and the IGF-1 system in esophageal adenocarcinoma and esophageal squamous-cell carcinoma (SCC). Methods: IGF-1 receptor (IGF-1R) mRNA and protein were examined in esophageal SCC (KYSE 410, OE21) and esophageal adenocarcinoma (OE19, OE33) cell lines by western blotting.

KW - adult

KW - aged

KW - article

KW - cancer surgery

KW - carcinoma cell

KW - cell count

KW - cell proliferation

KW - controlled study

KW - disease association

KW - enzyme

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IGF-1 and its receptor in esophageal cancer: Association with adenocarcinoma and visceral obesity

Abstract

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