The insulin-like growth factor (IGF) pathway and visceral obesity have been independently linked with esophageal cancer. This study aimed to delineate the differential and interlinked role of visceral obesity and the IGF-1 system in esophageal adenocarcinoma and esophageal squamous-cell carcinoma (SCC). Methods: IGF-1 receptor (IGF-1R) mRNA and protein were examined in esophageal SCC (KYSE 410, OE21) and esophageal adenocarcinoma (OE19, OE33) cell lines by western blotting.
Doyle, S., Donohoe, C., Finn, S., Howard, J., LITHANDER, F., Reynolds, J., Pidgeon, G., & Lysaght, J. (2012). IGF-1 and its receptor in esophageal cancer: Association with adenocarcinoma and visceral obesity. American Journal of Gastroenterology, 107(2), 196-204. https://doi.org/10.1038/ajg.2011.417