IGF-1 and its receptor in esophageal cancer: Association with adenocarcinoma and visceral obesity

Suzanne Doyle, Claire Donohoe, Stephen Finn, Julia Howard, Fiona LITHANDER, John Reynolds, Graham Pidgeon, Joanne Lysaght

Research output: Contribution to journalArticle

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Abstract

The insulin-like growth factor (IGF) pathway and visceral obesity have been independently linked with esophageal cancer. This study aimed to delineate the differential and interlinked role of visceral obesity and the IGF-1 system in esophageal adenocarcinoma and esophageal squamous-cell carcinoma (SCC). Methods: IGF-1 receptor (IGF-1R) mRNA and protein were examined in esophageal SCC (KYSE 410, OE21) and esophageal adenocarcinoma (OE19, OE33) cell lines by western blotting.
Original languageEnglish
Pages (from-to)196-204
Number of pages9
JournalAmerican Journal of Gastroenterology
Volume107
Issue number2
DOIs
Publication statusPublished - 2012
Externally publishedYes

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Abdominal Obesity
Somatomedins
Esophageal Neoplasms
Adenocarcinoma
Somatomedin Receptors
Western Blotting
Cell Line
Messenger RNA
Proteins
Esophageal Squamous Cell Carcinoma

Cite this

Doyle, S., Donohoe, C., Finn, S., Howard, J., LITHANDER, F., Reynolds, J., ... Lysaght, J. (2012). IGF-1 and its receptor in esophageal cancer: Association with adenocarcinoma and visceral obesity. American Journal of Gastroenterology, 107(2), 196-204. https://doi.org/10.1038/ajg.2011.417
Doyle, Suzanne ; Donohoe, Claire ; Finn, Stephen ; Howard, Julia ; LITHANDER, Fiona ; Reynolds, John ; Pidgeon, Graham ; Lysaght, Joanne. / IGF-1 and its receptor in esophageal cancer: Association with adenocarcinoma and visceral obesity. In: American Journal of Gastroenterology. 2012 ; Vol. 107, No. 2. pp. 196-204.
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Doyle, S, Donohoe, C, Finn, S, Howard, J, LITHANDER, F, Reynolds, J, Pidgeon, G & Lysaght, J 2012, 'IGF-1 and its receptor in esophageal cancer: Association with adenocarcinoma and visceral obesity', American Journal of Gastroenterology, vol. 107, no. 2, pp. 196-204. https://doi.org/10.1038/ajg.2011.417

IGF-1 and its receptor in esophageal cancer: Association with adenocarcinoma and visceral obesity. / Doyle, Suzanne; Donohoe, Claire; Finn, Stephen; Howard, Julia; LITHANDER, Fiona; Reynolds, John; Pidgeon, Graham; Lysaght, Joanne.

In: American Journal of Gastroenterology, Vol. 107, No. 2, 2012, p. 196-204.

Research output: Contribution to journalArticle

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AU - Pidgeon, Graham

AU - Lysaght, Joanne

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