TY - JOUR
T1 - Imaging focal and interstitial fibrosis with cardiovascular magnetic resonance in athletes with left ventricular hypertrophy
T2 - Implications for sporting participation
AU - Waterhouse, Deirdre F.
AU - Ismail, Tevfik F.
AU - Prasad, Sanjay K.
AU - Wilson, Mathew G.
AU - O'Hanlon, Rory
PY - 2012/11
Y1 - 2012/11
N2 - Long-term high-intensity physical activity is associated with morphological changes, termed as the 'athlete's heart'. The differentiation of physiological cardiac adaptive changes in response to high-level exercise from pathological changes consistent with an inherited cardiomyopathy is imperative. Cardiovascular magnetic resonance (CMR) imaging allows definition of abnormal processes occurring at the tissue level, including, importantly, myocardial fibrosis. It is therefore vital in accurately making this differentiation. In this review, we will review the role of CMR imaging of fibrosis, and detail CMR characterisation of myocardial fibrosis in various cardiomyopathies, and the implications of fibrosis. Additionally, we will outline advances in imaging fibrosis, in particular T1 mapping. Finally we will address the role of CMR in pre-participation screening.
AB - Long-term high-intensity physical activity is associated with morphological changes, termed as the 'athlete's heart'. The differentiation of physiological cardiac adaptive changes in response to high-level exercise from pathological changes consistent with an inherited cardiomyopathy is imperative. Cardiovascular magnetic resonance (CMR) imaging allows definition of abnormal processes occurring at the tissue level, including, importantly, myocardial fibrosis. It is therefore vital in accurately making this differentiation. In this review, we will review the role of CMR imaging of fibrosis, and detail CMR characterisation of myocardial fibrosis in various cardiomyopathies, and the implications of fibrosis. Additionally, we will outline advances in imaging fibrosis, in particular T1 mapping. Finally we will address the role of CMR in pre-participation screening.
UR - http://www.scopus.com/inward/record.url?scp=84869043912&partnerID=8YFLogxK
U2 - 10.1136/bjsports-2012-091482
DO - 10.1136/bjsports-2012-091482
M3 - Article
C2 - 23097483
AN - SCOPUS:84869043912
SN - 0306-3674
VL - 46
SP - 69
EP - 75
JO - British Journal of Sports Medicine
JF - British Journal of Sports Medicine
IS - SUPPL. 1
ER -