Immunopathology of rsv: An updated review

Harrison C. Bergeron; Ralph A. Tripp

doi:10.3390/v13122478

Immunopathology of rsv: An updated review

Harrison C. Bergeron, Ralph A. Tripp

Research output: Contribution to journal › Review article › peer-review

51 Citations (Scopus)

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Abstract

RSV is a leading cause of respiratory tract disease in infants and the elderly. RSV has limited therapeutic interventions and no FDA-approved vaccine. Gaps in our understanding of virus–host interactions and immunity contribute to the lack of biological countermeasures. This review updates the current understanding of RSV immunity and immunopathology with a focus on interferon responses, animal modeling, and correlates of protection.

Original language	English
Article number	2478
Pages (from-to)	1-30
Number of pages	30
Journal	Viruses
Volume	13
Issue number	12
DOIs	https://doi.org/10.3390/v13122478
Publication status	Published - Dec 2021
Externally published	Yes

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10.3390/v13122478Licence: CC BY

ArticleFinal published version, 545 KBLicence: CC BY

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keywords = "Host–pathogen interaction, Immunity, Immunopathology, Respiratory syncytial virus, RSV",

author = "Bergeron, {Harrison C.} and Tripp, {Ralph A.}",

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N2 - RSV is a leading cause of respiratory tract disease in infants and the elderly. RSV has limited therapeutic interventions and no FDA-approved vaccine. Gaps in our understanding of virus–host interactions and immunity contribute to the lack of biological countermeasures. This review updates the current understanding of RSV immunity and immunopathology with a focus on interferon responses, animal modeling, and correlates of protection.

AB - RSV is a leading cause of respiratory tract disease in infants and the elderly. RSV has limited therapeutic interventions and no FDA-approved vaccine. Gaps in our understanding of virus–host interactions and immunity contribute to the lack of biological countermeasures. This review updates the current understanding of RSV immunity and immunopathology with a focus on interferon responses, animal modeling, and correlates of protection.

KW - Host–pathogen interaction

KW - Immunity

KW - Immunopathology

KW - Respiratory syncytial virus

KW - RSV

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Immunopathology of rsv: An updated review

Abstract

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