Immunopathology of rsv: An updated review

Harrison C. Bergeron; Ralph A. Tripp

doi:10.3390/v13122478

Immunopathology of rsv: An updated review

Harrison C. Bergeron
, Ralph A. Tripp

Research output: Contribution to journal › Review article › peer-review

89 Citations (Scopus)

174 Downloads (Pure)

Abstract

RSV is a leading cause of respiratory tract disease in infants and the elderly. RSV has limited therapeutic interventions and no FDA-approved vaccine. Gaps in our understanding of virus–host interactions and immunity contribute to the lack of biological countermeasures. This review updates the current understanding of RSV immunity and immunopathology with a focus on interferon responses, animal modeling, and correlates of protection.

Original language	English
Article number	2478
Pages (from-to)	1-30
Number of pages	30
Journal	Viruses
Volume	13
Issue number	12
DOIs	https://doi.org/10.3390/v13122478
Publication status	Published - Dec 2021
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.3390/v13122478Licence: CC BY

ArticleFinal published version, 545 KBLicence: CC BY

Cite this

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title = "Immunopathology of rsv: An updated review",

abstract = "RSV is a leading cause of respiratory tract disease in infants and the elderly. RSV has limited therapeutic interventions and no FDA-approved vaccine. Gaps in our understanding of virus–host interactions and immunity contribute to the lack of biological countermeasures. This review updates the current understanding of RSV immunity and immunopathology with a focus on interferon responses, animal modeling, and correlates of protection.",

keywords = "Host–pathogen interaction, Immunity, Immunopathology, Respiratory syncytial virus, RSV",

author = "Bergeron, \{Harrison C.\} and Tripp, \{Ralph A.\}",

note = "Funding Information: Funding: This research was funded by the Tripp laboratory, and supported by the Georgia Research Alliance (GRA). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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AU - Tripp, Ralph A.

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PY - 2021/12

Y1 - 2021/12

N2 - RSV is a leading cause of respiratory tract disease in infants and the elderly. RSV has limited therapeutic interventions and no FDA-approved vaccine. Gaps in our understanding of virus–host interactions and immunity contribute to the lack of biological countermeasures. This review updates the current understanding of RSV immunity and immunopathology with a focus on interferon responses, animal modeling, and correlates of protection.

AB - RSV is a leading cause of respiratory tract disease in infants and the elderly. RSV has limited therapeutic interventions and no FDA-approved vaccine. Gaps in our understanding of virus–host interactions and immunity contribute to the lack of biological countermeasures. This review updates the current understanding of RSV immunity and immunopathology with a focus on interferon responses, animal modeling, and correlates of protection.

KW - Host–pathogen interaction

KW - Immunity

KW - Immunopathology

KW - Respiratory syncytial virus

KW - RSV

UR - https://www.scopus.com/pages/publications/85121427632

U2 - 10.3390/v13122478

DO - 10.3390/v13122478

M3 - Review article

C2 - 34960746

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JO - Viruses

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ER -

Immunopathology of rsv: An updated review

Abstract

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