Impact of age and body size on inter-individual variation in measures of lipid metabolism

Influence of gender and apolipoprotein E genotype

S. Lussier-Cacan, A. Bolduc, M. Xhignesse, T. Niyonsenga, P. W. Connelly, C. F. Sing

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

This study was undertaken in 1695 adult subjects (870 women and 825 men) in order to further document the complexity of the influence of the apolipoprotein (apo) E genotypes on the mean levels and intragenotypic variability of seven measures of lipid metabolism. In addition, the statistical relationships between variability in these traits and variation in age, body mass index (BMI) and waist-to-hip ratio (WHR) were assessed. The contribution of variation in age and body size to inter-individual variation was found to be dependent on context, defined by gender and apo E genotype. Our findings are consistent with the reality that it is neither genes nor environments, but their interactions that are responsible for the variation in risk of cardiovascular disease.

Original languageEnglish
Pages (from-to)35-47
Number of pages13
JournalClinical Genetics
Volume57
Issue number1
DOIs
Publication statusPublished - 2 Mar 2000
Externally publishedYes

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Body Size
Apolipoproteins E
Lipid Metabolism
Genotype
Waist-Hip Ratio
Body Mass Index
Cardiovascular Diseases
Genes

Cite this

Lussier-Cacan, S. ; Bolduc, A. ; Xhignesse, M. ; Niyonsenga, T. ; Connelly, P. W. ; Sing, C. F. / Impact of age and body size on inter-individual variation in measures of lipid metabolism : Influence of gender and apolipoprotein E genotype. In: Clinical Genetics. 2000 ; Vol. 57, No. 1. pp. 35-47.
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Impact of age and body size on inter-individual variation in measures of lipid metabolism : Influence of gender and apolipoprotein E genotype. / Lussier-Cacan, S.; Bolduc, A.; Xhignesse, M.; Niyonsenga, T.; Connelly, P. W.; Sing, C. F.

In: Clinical Genetics, Vol. 57, No. 1, 02.03.2000, p. 35-47.

Research output: Contribution to journalArticle

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