Impaired muscle strength may contribute to fatigue in patients with aneurysmal subarachnoid hemorrhage

Wouter J. Harmsen, Gerard M. Ribbers, Bart Zegers, Emiel M. Sneekes, Stephan F.E. Praet, Majanka H. Heijenbrok-Kal, Ladbon Khajeh, Fop Van Kooten, Sebastiaan J.C.M.M. Neggers, Rita J. Van Den Berg-Emons

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Patients with aneurysmal subarachnoid hemorrhage (a-SAH) show long-term fatigue and face difficulties in resuming daily physical activities. Impaired muscle strength, especially of the lower extremity, impacts the performance of daily activities and may trigger the onset of fatigue complaints. The present study evaluated knee muscle strength and fatigue in patients with a-SAH. This study included 33 patients, 6 months after a-SAH, and 33 sex-matched and age-matched healthy controls. Isokinetic muscle strength of the knee extensors and flexors was measured at 60 and 180°/s. Maximal voluntary muscle strength was defined as peak torque and measured in Newton-meter. Fatigue was examined using the Fatigue Severity Scale. In patients with a-SAH, the maximal knee extension was 22% (60°/s) and 25% (180°/s) lower and maximal knee flexion was 33% (60°/s) and 36% (180°/s) lower compared with that of matched controls (P≤0.001). The Fatigue Severity Scale score was related to maximal knee extension (60°/s: r=-0.426, P=0.015; 180°/s: r=-0.376, P=0.034) and flexion (60°/s: r=-0.482, P=0.005; 180°/s: r=-0.344, P=0.083). The knee muscle strength was 28-47% lower in fatigued (n=13) and 11-32% lower in nonfatigued (n=20) patients; deficits were larger in fatigued patients (P<0.05), particularly when the muscle strength (peak torque) was measured at 60°/s. The present results indicate that patients with a-SAH have considerably impaired knee muscle strength, which is related to more severe fatigue. The present findings are exploratory, but showed that knee muscle strength may play a role in the severity of fatigue complaints, or vice versa. Interventions targeting fatigue after a-SAH seem necessary and may consider strengthening exercise training in order to treat a debilitating condition.

Original languageEnglish
Pages (from-to)29-36
Number of pages8
JournalInternational Journal of Rehabilitation Research
Volume40
Issue number1
DOIs
Publication statusPublished - 2017
Externally publishedYes

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Muscle Strength
Subarachnoid Hemorrhage
Fatigue
Knee
Torque
Exercise
Muscle Fatigue
Lower Extremity
Skeletal Muscle

Cite this

Harmsen, W. J., Ribbers, G. M., Zegers, B., Sneekes, E. M., Praet, S. F. E., Heijenbrok-Kal, M. H., ... Van Den Berg-Emons, R. J. (2017). Impaired muscle strength may contribute to fatigue in patients with aneurysmal subarachnoid hemorrhage. International Journal of Rehabilitation Research, 40(1), 29-36. https://doi.org/10.1097/MRR.0000000000000197
Harmsen, Wouter J. ; Ribbers, Gerard M. ; Zegers, Bart ; Sneekes, Emiel M. ; Praet, Stephan F.E. ; Heijenbrok-Kal, Majanka H. ; Khajeh, Ladbon ; Van Kooten, Fop ; Neggers, Sebastiaan J.C.M.M. ; Van Den Berg-Emons, Rita J. / Impaired muscle strength may contribute to fatigue in patients with aneurysmal subarachnoid hemorrhage. In: International Journal of Rehabilitation Research. 2017 ; Vol. 40, No. 1. pp. 29-36.
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abstract = "Patients with aneurysmal subarachnoid hemorrhage (a-SAH) show long-term fatigue and face difficulties in resuming daily physical activities. Impaired muscle strength, especially of the lower extremity, impacts the performance of daily activities and may trigger the onset of fatigue complaints. The present study evaluated knee muscle strength and fatigue in patients with a-SAH. This study included 33 patients, 6 months after a-SAH, and 33 sex-matched and age-matched healthy controls. Isokinetic muscle strength of the knee extensors and flexors was measured at 60 and 180°/s. Maximal voluntary muscle strength was defined as peak torque and measured in Newton-meter. Fatigue was examined using the Fatigue Severity Scale. In patients with a-SAH, the maximal knee extension was 22{\%} (60°/s) and 25{\%} (180°/s) lower and maximal knee flexion was 33{\%} (60°/s) and 36{\%} (180°/s) lower compared with that of matched controls (P≤0.001). The Fatigue Severity Scale score was related to maximal knee extension (60°/s: r=-0.426, P=0.015; 180°/s: r=-0.376, P=0.034) and flexion (60°/s: r=-0.482, P=0.005; 180°/s: r=-0.344, P=0.083). The knee muscle strength was 28-47{\%} lower in fatigued (n=13) and 11-32{\%} lower in nonfatigued (n=20) patients; deficits were larger in fatigued patients (P<0.05), particularly when the muscle strength (peak torque) was measured at 60°/s. The present results indicate that patients with a-SAH have considerably impaired knee muscle strength, which is related to more severe fatigue. The present findings are exploratory, but showed that knee muscle strength may play a role in the severity of fatigue complaints, or vice versa. Interventions targeting fatigue after a-SAH seem necessary and may consider strengthening exercise training in order to treat a debilitating condition.",
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Harmsen, WJ, Ribbers, GM, Zegers, B, Sneekes, EM, Praet, SFE, Heijenbrok-Kal, MH, Khajeh, L, Van Kooten, F, Neggers, SJCMM & Van Den Berg-Emons, RJ 2017, 'Impaired muscle strength may contribute to fatigue in patients with aneurysmal subarachnoid hemorrhage', International Journal of Rehabilitation Research, vol. 40, no. 1, pp. 29-36. https://doi.org/10.1097/MRR.0000000000000197

Impaired muscle strength may contribute to fatigue in patients with aneurysmal subarachnoid hemorrhage. / Harmsen, Wouter J.; Ribbers, Gerard M.; Zegers, Bart; Sneekes, Emiel M.; Praet, Stephan F.E.; Heijenbrok-Kal, Majanka H.; Khajeh, Ladbon; Van Kooten, Fop; Neggers, Sebastiaan J.C.M.M.; Van Den Berg-Emons, Rita J.

In: International Journal of Rehabilitation Research, Vol. 40, No. 1, 2017, p. 29-36.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impaired muscle strength may contribute to fatigue in patients with aneurysmal subarachnoid hemorrhage

AU - Harmsen, Wouter J.

AU - Ribbers, Gerard M.

AU - Zegers, Bart

AU - Sneekes, Emiel M.

AU - Praet, Stephan F.E.

AU - Heijenbrok-Kal, Majanka H.

AU - Khajeh, Ladbon

AU - Van Kooten, Fop

AU - Neggers, Sebastiaan J.C.M.M.

AU - Van Den Berg-Emons, Rita J.

PY - 2017

Y1 - 2017

N2 - Patients with aneurysmal subarachnoid hemorrhage (a-SAH) show long-term fatigue and face difficulties in resuming daily physical activities. Impaired muscle strength, especially of the lower extremity, impacts the performance of daily activities and may trigger the onset of fatigue complaints. The present study evaluated knee muscle strength and fatigue in patients with a-SAH. This study included 33 patients, 6 months after a-SAH, and 33 sex-matched and age-matched healthy controls. Isokinetic muscle strength of the knee extensors and flexors was measured at 60 and 180°/s. Maximal voluntary muscle strength was defined as peak torque and measured in Newton-meter. Fatigue was examined using the Fatigue Severity Scale. In patients with a-SAH, the maximal knee extension was 22% (60°/s) and 25% (180°/s) lower and maximal knee flexion was 33% (60°/s) and 36% (180°/s) lower compared with that of matched controls (P≤0.001). The Fatigue Severity Scale score was related to maximal knee extension (60°/s: r=-0.426, P=0.015; 180°/s: r=-0.376, P=0.034) and flexion (60°/s: r=-0.482, P=0.005; 180°/s: r=-0.344, P=0.083). The knee muscle strength was 28-47% lower in fatigued (n=13) and 11-32% lower in nonfatigued (n=20) patients; deficits were larger in fatigued patients (P<0.05), particularly when the muscle strength (peak torque) was measured at 60°/s. The present results indicate that patients with a-SAH have considerably impaired knee muscle strength, which is related to more severe fatigue. The present findings are exploratory, but showed that knee muscle strength may play a role in the severity of fatigue complaints, or vice versa. Interventions targeting fatigue after a-SAH seem necessary and may consider strengthening exercise training in order to treat a debilitating condition.

AB - Patients with aneurysmal subarachnoid hemorrhage (a-SAH) show long-term fatigue and face difficulties in resuming daily physical activities. Impaired muscle strength, especially of the lower extremity, impacts the performance of daily activities and may trigger the onset of fatigue complaints. The present study evaluated knee muscle strength and fatigue in patients with a-SAH. This study included 33 patients, 6 months after a-SAH, and 33 sex-matched and age-matched healthy controls. Isokinetic muscle strength of the knee extensors and flexors was measured at 60 and 180°/s. Maximal voluntary muscle strength was defined as peak torque and measured in Newton-meter. Fatigue was examined using the Fatigue Severity Scale. In patients with a-SAH, the maximal knee extension was 22% (60°/s) and 25% (180°/s) lower and maximal knee flexion was 33% (60°/s) and 36% (180°/s) lower compared with that of matched controls (P≤0.001). The Fatigue Severity Scale score was related to maximal knee extension (60°/s: r=-0.426, P=0.015; 180°/s: r=-0.376, P=0.034) and flexion (60°/s: r=-0.482, P=0.005; 180°/s: r=-0.344, P=0.083). The knee muscle strength was 28-47% lower in fatigued (n=13) and 11-32% lower in nonfatigued (n=20) patients; deficits were larger in fatigued patients (P<0.05), particularly when the muscle strength (peak torque) was measured at 60°/s. The present results indicate that patients with a-SAH have considerably impaired knee muscle strength, which is related to more severe fatigue. The present findings are exploratory, but showed that knee muscle strength may play a role in the severity of fatigue complaints, or vice versa. Interventions targeting fatigue after a-SAH seem necessary and may consider strengthening exercise training in order to treat a debilitating condition.

KW - fatigue

KW - muscle strength

KW - physical fitness

KW - rehabilitation

KW - subarachnoid hemorrhage

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