Improvement in muscular strength in HIV-infected individuals receiving antiretroviral therapy

Takshita Sookan, Ayesha Motala, Michael Ormsbee, Jose Antonio, Nombulelo Magula, Umesh Lalloo, Andrew McKune

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Purpose: This study investigated (1) the effect of a progressive resistance training (PRT) program and whey protein intake on maximal muscle strength in human immunodeficiency virus (HIV)-infected individuals receiving antiretroviral therapy (ART) and (2) alterations in maximal strength 12 wks after the cessation of PRT with continued supplementation. Methods: Sixty HIV-infected individuals were recruited. Whole body PRT was performed twice weekly for 12 wks. Participants received, in a double-blind placebo controlled manner, either 20 g whey or placebo (maltodextrin) before and immediately after each session. Both PRT groups continued to take either whey protein or placebo for a further 12 wks following the exercise intervention to examine the effects of detraining. Results: Forty participants (mean and standard deviation (SD) age 40.8 (±7.7) years, weight 70.8 (±16) kg, body mass index (BMI) 30.9 (±7.2) kg m2); whey protein /PRT (n = 13), placebo/PRT (n = 17), and a control group (n = 10) completed the study. A significant main effect for time occurred for the bench press (p = 0.02), the squat (p < 0.0001), the deadlift (p = 0.001) and the shoulder press (p = 0.02) one-repetition maximum (1RM) in the intervention groups. Conclusion: The PRT program increased maximal strength regardless of whey protein intake. The detraining period demonstrated minimal strength loss, which is beneficial to this population.

Original languageEnglish
Article number66
Pages (from-to)1-13
Number of pages13
JournalJournal of Functional Morphology and Kinesiology
Issue number3
Publication statusPublished - Sept 2019


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