In Vivo Function and Evolution of the Eutherian-Specific Pluripotency Marker UTF1

Masazumi Nishimoto, Miyuki Katano, Toshiyuki Yamagishi, Tomoaki Hishida, Masayoshi Kamon, Ayumu Suzuki, Masataka Hirasaki, Yoko Nabeshima, Yo-ichi Nabeshima, Yukako Katsura, Yoko Satta, Janine Deakin, Jennifer Marshall Graves, Yoko Kuroki, Ryuichi Ono, Fumitoshi Ishino, Masatsugu Ema, Satoru Takahashi, Hidemasa Kato, Akihiko Okuda

Research output: Contribution to journalArticle

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Abstract

Embryogenesis in placental mammals is sustained by exquisite interplay between the embryo proper and placenta. UTF1 is a developmentally regulated gene expressed in both cell lineages. Here, we analyzed the consequence of loss of the UTF1 gene during mouse development. We found that homozygous UTF1 mutant newborn mice were significantly smaller than wild-type or heterozygous mutant mice, suggesting that placental insufficiency caused by the loss of UTF1 expression in extra-embryonic ectodermal cells at least in part contributed to this phenotype. We also found that the effects of loss of UTF1 expression in embryonic stem cells on their pluripotency were very subtle. Genome structure and sequence comparisons revealed that the UTF1 gene exists only in placental mammals. Our analyses of a family of genes with homology to UTF1 revealed a possible mechanism by which placental mammals have evolved the UTF1 genes.
Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalPLoS One
Volume8
DOIs
Publication statusPublished - 2013
Externally publishedYes

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Genes
Mammals
mammals
genes
mice
Placental Insufficiency
mutants
embryonic stem cells
Cell Lineage
Embryonic Stem Cells
placenta
Placenta
Embryonic Development
Stem cells
embryo (animal)
neonates
embryogenesis
Embryonic Structures
Genome
cells

Cite this

Nishimoto, M., Katano, M., Yamagishi, T., Hishida, T., Kamon, M., Suzuki, A., ... Okuda, A. (2013). In Vivo Function and Evolution of the Eutherian-Specific Pluripotency Marker UTF1. PLoS One, 8, 1-14. https://doi.org/10.1371/journal.pone.0068119
Nishimoto, Masazumi ; Katano, Miyuki ; Yamagishi, Toshiyuki ; Hishida, Tomoaki ; Kamon, Masayoshi ; Suzuki, Ayumu ; Hirasaki, Masataka ; Nabeshima, Yoko ; Nabeshima, Yo-ichi ; Katsura, Yukako ; Satta, Yoko ; Deakin, Janine ; Marshall Graves, Jennifer ; Kuroki, Yoko ; Ono, Ryuichi ; Ishino, Fumitoshi ; Ema, Masatsugu ; Takahashi, Satoru ; Kato, Hidemasa ; Okuda, Akihiko. / In Vivo Function and Evolution of the Eutherian-Specific Pluripotency Marker UTF1. In: PLoS One. 2013 ; Vol. 8. pp. 1-14.
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abstract = "Embryogenesis in placental mammals is sustained by exquisite interplay between the embryo proper and placenta. UTF1 is a developmentally regulated gene expressed in both cell lineages. Here, we analyzed the consequence of loss of the UTF1 gene during mouse development. We found that homozygous UTF1 mutant newborn mice were significantly smaller than wild-type or heterozygous mutant mice, suggesting that placental insufficiency caused by the loss of UTF1 expression in extra-embryonic ectodermal cells at least in part contributed to this phenotype. We also found that the effects of loss of UTF1 expression in embryonic stem cells on their pluripotency were very subtle. Genome structure and sequence comparisons revealed that the UTF1 gene exists only in placental mammals. Our analyses of a family of genes with homology to UTF1 revealed a possible mechanism by which placental mammals have evolved the UTF1 genes.",
author = "Masazumi Nishimoto and Miyuki Katano and Toshiyuki Yamagishi and Tomoaki Hishida and Masayoshi Kamon and Ayumu Suzuki and Masataka Hirasaki and Yoko Nabeshima and Yo-ichi Nabeshima and Yukako Katsura and Yoko Satta and Janine Deakin and {Marshall Graves}, Jennifer and Yoko Kuroki and Ryuichi Ono and Fumitoshi Ishino and Masatsugu Ema and Satoru Takahashi and Hidemasa Kato and Akihiko Okuda",
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Nishimoto, M, Katano, M, Yamagishi, T, Hishida, T, Kamon, M, Suzuki, A, Hirasaki, M, Nabeshima, Y, Nabeshima, Y, Katsura, Y, Satta, Y, Deakin, J, Marshall Graves, J, Kuroki, Y, Ono, R, Ishino, F, Ema, M, Takahashi, S, Kato, H & Okuda, A 2013, 'In Vivo Function and Evolution of the Eutherian-Specific Pluripotency Marker UTF1', PLoS One, vol. 8, pp. 1-14. https://doi.org/10.1371/journal.pone.0068119

In Vivo Function and Evolution of the Eutherian-Specific Pluripotency Marker UTF1. / Nishimoto, Masazumi; Katano, Miyuki; Yamagishi, Toshiyuki; Hishida, Tomoaki; Kamon, Masayoshi; Suzuki, Ayumu; Hirasaki, Masataka; Nabeshima, Yoko; Nabeshima, Yo-ichi; Katsura, Yukako; Satta, Yoko; Deakin, Janine; Marshall Graves, Jennifer; Kuroki, Yoko; Ono, Ryuichi; Ishino, Fumitoshi; Ema, Masatsugu; Takahashi, Satoru; Kato, Hidemasa; Okuda, Akihiko.

In: PLoS One, Vol. 8, 2013, p. 1-14.

Research output: Contribution to journalArticle

TY - JOUR

T1 - In Vivo Function and Evolution of the Eutherian-Specific Pluripotency Marker UTF1

AU - Nishimoto, Masazumi

AU - Katano, Miyuki

AU - Yamagishi, Toshiyuki

AU - Hishida, Tomoaki

AU - Kamon, Masayoshi

AU - Suzuki, Ayumu

AU - Hirasaki, Masataka

AU - Nabeshima, Yoko

AU - Nabeshima, Yo-ichi

AU - Katsura, Yukako

AU - Satta, Yoko

AU - Deakin, Janine

AU - Marshall Graves, Jennifer

AU - Kuroki, Yoko

AU - Ono, Ryuichi

AU - Ishino, Fumitoshi

AU - Ema, Masatsugu

AU - Takahashi, Satoru

AU - Kato, Hidemasa

AU - Okuda, Akihiko

PY - 2013

Y1 - 2013

N2 - Embryogenesis in placental mammals is sustained by exquisite interplay between the embryo proper and placenta. UTF1 is a developmentally regulated gene expressed in both cell lineages. Here, we analyzed the consequence of loss of the UTF1 gene during mouse development. We found that homozygous UTF1 mutant newborn mice were significantly smaller than wild-type or heterozygous mutant mice, suggesting that placental insufficiency caused by the loss of UTF1 expression in extra-embryonic ectodermal cells at least in part contributed to this phenotype. We also found that the effects of loss of UTF1 expression in embryonic stem cells on their pluripotency were very subtle. Genome structure and sequence comparisons revealed that the UTF1 gene exists only in placental mammals. Our analyses of a family of genes with homology to UTF1 revealed a possible mechanism by which placental mammals have evolved the UTF1 genes.

AB - Embryogenesis in placental mammals is sustained by exquisite interplay between the embryo proper and placenta. UTF1 is a developmentally regulated gene expressed in both cell lineages. Here, we analyzed the consequence of loss of the UTF1 gene during mouse development. We found that homozygous UTF1 mutant newborn mice were significantly smaller than wild-type or heterozygous mutant mice, suggesting that placental insufficiency caused by the loss of UTF1 expression in extra-embryonic ectodermal cells at least in part contributed to this phenotype. We also found that the effects of loss of UTF1 expression in embryonic stem cells on their pluripotency were very subtle. Genome structure and sequence comparisons revealed that the UTF1 gene exists only in placental mammals. Our analyses of a family of genes with homology to UTF1 revealed a possible mechanism by which placental mammals have evolved the UTF1 genes.

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DO - 10.1371/journal.pone.0068119

M3 - Article

VL - 8

SP - 1

EP - 14

JO - PLoS One

JF - PLoS One

SN - 1932-6203

ER -

Nishimoto M, Katano M, Yamagishi T, Hishida T, Kamon M, Suzuki A et al. In Vivo Function and Evolution of the Eutherian-Specific Pluripotency Marker UTF1. PLoS One. 2013;8:1-14. https://doi.org/10.1371/journal.pone.0068119