Increased epicardial fat thickness in sudden death from stable coronary artery atherosclerosis

Belinda Fuller, Jack Garland, Sravan Anne, Raymond Beh, Dennis McNevin, Rexson Tse

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    Background: Sudden death from stable coronary artery atherosclerosis (SCAA) is well recognized. However, individuals can have ischemic heart disease or coronary artery atherosclerosis but die of noncardiac causes. Recently, it has been recognized that increased epicardial fat is detrimental to normal heart function. We hypothesize that individuals who die of SCAA have increased epicardial fat. Aim: The aim of this study was to investigate whether there is an increase in epicardial fat in individuals who suddenly died of SCAA. Methods: This was a 1-year retrospective study comparing the average epicardial fat thickness using postmortem computed tomography scan between individuals who suddenly died of SCAA (SCAA group) with individuals who primarily died of natural noncardiac causes but had established ischemic heart disease or significant coronary artery atherosclerosis (NCC group). Results: Average epicardial fat thickness was significantly higher in the SCAA group (8 ± 2 mm) than in the NCC group (6 ± 2 mm, P = 0.008). Conclusions: Individuals who die of SCAA appear to have higher epicardial fat thickness. The increase in epicardial fat may have an additional detrimental effect to the heart predisposing sudden death in individuals with coronary artery atherosclerosis.

    Original languageEnglish
    Pages (from-to)162-166
    Number of pages5
    JournalAmerican Journal of Forensic Medicine and Pathology
    Volume38
    Issue number2
    DOIs
    Publication statusPublished - 1 Jan 2017

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    Sudden Death
    Coronary Artery Disease
    Coronary Vessels
    Fats
    Myocardial Ischemia
    Retrospective Studies
    Tomography

    Cite this

    Fuller, Belinda ; Garland, Jack ; Anne, Sravan ; Beh, Raymond ; McNevin, Dennis ; Tse, Rexson. / Increased epicardial fat thickness in sudden death from stable coronary artery atherosclerosis. In: American Journal of Forensic Medicine and Pathology. 2017 ; Vol. 38, No. 2. pp. 162-166.
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    abstract = "Background: Sudden death from stable coronary artery atherosclerosis (SCAA) is well recognized. However, individuals can have ischemic heart disease or coronary artery atherosclerosis but die of noncardiac causes. Recently, it has been recognized that increased epicardial fat is detrimental to normal heart function. We hypothesize that individuals who die of SCAA have increased epicardial fat. Aim: The aim of this study was to investigate whether there is an increase in epicardial fat in individuals who suddenly died of SCAA. Methods: This was a 1-year retrospective study comparing the average epicardial fat thickness using postmortem computed tomography scan between individuals who suddenly died of SCAA (SCAA group) with individuals who primarily died of natural noncardiac causes but had established ischemic heart disease or significant coronary artery atherosclerosis (NCC group). Results: Average epicardial fat thickness was significantly higher in the SCAA group (8 ± 2 mm) than in the NCC group (6 ± 2 mm, P = 0.008). Conclusions: Individuals who die of SCAA appear to have higher epicardial fat thickness. The increase in epicardial fat may have an additional detrimental effect to the heart predisposing sudden death in individuals with coronary artery atherosclerosis.",
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    Increased epicardial fat thickness in sudden death from stable coronary artery atherosclerosis. / Fuller, Belinda; Garland, Jack; Anne, Sravan; Beh, Raymond; McNevin, Dennis; Tse, Rexson.

    In: American Journal of Forensic Medicine and Pathology, Vol. 38, No. 2, 01.01.2017, p. 162-166.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Increased epicardial fat thickness in sudden death from stable coronary artery atherosclerosis

    AU - Fuller, Belinda

    AU - Garland, Jack

    AU - Anne, Sravan

    AU - Beh, Raymond

    AU - McNevin, Dennis

    AU - Tse, Rexson

    PY - 2017/1/1

    Y1 - 2017/1/1

    N2 - Background: Sudden death from stable coronary artery atherosclerosis (SCAA) is well recognized. However, individuals can have ischemic heart disease or coronary artery atherosclerosis but die of noncardiac causes. Recently, it has been recognized that increased epicardial fat is detrimental to normal heart function. We hypothesize that individuals who die of SCAA have increased epicardial fat. Aim: The aim of this study was to investigate whether there is an increase in epicardial fat in individuals who suddenly died of SCAA. Methods: This was a 1-year retrospective study comparing the average epicardial fat thickness using postmortem computed tomography scan between individuals who suddenly died of SCAA (SCAA group) with individuals who primarily died of natural noncardiac causes but had established ischemic heart disease or significant coronary artery atherosclerosis (NCC group). Results: Average epicardial fat thickness was significantly higher in the SCAA group (8 ± 2 mm) than in the NCC group (6 ± 2 mm, P = 0.008). Conclusions: Individuals who die of SCAA appear to have higher epicardial fat thickness. The increase in epicardial fat may have an additional detrimental effect to the heart predisposing sudden death in individuals with coronary artery atherosclerosis.

    AB - Background: Sudden death from stable coronary artery atherosclerosis (SCAA) is well recognized. However, individuals can have ischemic heart disease or coronary artery atherosclerosis but die of noncardiac causes. Recently, it has been recognized that increased epicardial fat is detrimental to normal heart function. We hypothesize that individuals who die of SCAA have increased epicardial fat. Aim: The aim of this study was to investigate whether there is an increase in epicardial fat in individuals who suddenly died of SCAA. Methods: This was a 1-year retrospective study comparing the average epicardial fat thickness using postmortem computed tomography scan between individuals who suddenly died of SCAA (SCAA group) with individuals who primarily died of natural noncardiac causes but had established ischemic heart disease or significant coronary artery atherosclerosis (NCC group). Results: Average epicardial fat thickness was significantly higher in the SCAA group (8 ± 2 mm) than in the NCC group (6 ± 2 mm, P = 0.008). Conclusions: Individuals who die of SCAA appear to have higher epicardial fat thickness. The increase in epicardial fat may have an additional detrimental effect to the heart predisposing sudden death in individuals with coronary artery atherosclerosis.

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    KW - Epicardial fat

    KW - Ischemic heart disease

    KW - Postmortem CT

    KW - Humans

    KW - Middle Aged

    KW - Adipose Tissue/diagnostic imaging

    KW - Male

    KW - Tomography, X-Ray Computed

    KW - Death, Sudden, Cardiac/etiology

    KW - Pericardium/diagnostic imaging

    KW - Coronary Artery Disease/mortality

    KW - Aged, 80 and over

    KW - Adult

    KW - Female

    KW - Aged

    KW - Retrospective Studies

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    UR - http://www.mendeley.com/research/increased-epicardial-fat-thickness-sudden-death-stable-coronary-artery-atherosclerosis

    U2 - 10.1097/PAF.0000000000000310

    DO - 10.1097/PAF.0000000000000310

    M3 - Article

    VL - 38

    SP - 162

    EP - 166

    JO - American Journal of Forensic Medicine and Pathology

    JF - American Journal of Forensic Medicine and Pathology

    SN - 0195-7910

    IS - 2

    ER -