Increased left ventricular trabeculation in highly trained athletes

Do we need more stringent criteria for the diagnosis of left ventricular non-compaction in athletes?

Sabiha Gati, Navin Chandra, Rachel Louise Bennett, Matt Reed, Gaelle Kervio, Vasileios F. Panoulas, Saqib Ghani, Nabeel Sheikh, Abbas Zaidi, Matthew Wilson, Michael Papadakis, Francois Carré, Sanjay Sharma

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Objective To investigate the prevalence and significance of increased left ventricular (LV) trabeculation in highly trained athletes. Design Cross sectional echocardiographic study. Setting Sports cardiology institutions in the UK and France. Subjects 1146 athletes aged 14-35 years (63.3% male), participating in 27 sporting disciplines, and 415 healthy controls of similar age. The results of athletes fulfilling conventional criteria for LV non-compaction (LVNC) were compared with 75 patients with LVNC. Main outcome measure Number of athletes with increased LV trabeculation and the number fulfilling criteria for LVNC. Results Athletes displayed a higher prevalence of increased LV trabeculation compared with controls (18.3% vs 7.0%; p≤0.0001) and 8.1% athletes fulfilled conventional criteria for LVNC. Increased LV trabeculation were more common in athletes of African/Afro-Caribbean origin. A small proportion of athletes (n=10; 0.9%) revealed reduced systolic function and marked repolarisation changes in association with echocardiographic criteria for LVNC raising the possibility of an underlying cardiomyopathy. Follow-up during the ensuing 48.6±14.6 months did not reveal adverse events. Conclusions A high proportion of young athletes exhibit conventional criteria for LVNC highlighting the non-specific nature of current diagnostic criteria if applied to elite athletic populations. Further assessment of such athletes should be confined to the small minority that demonstrate low indices of systolic function and marked repolarisation changes.

Original languageEnglish
Pages (from-to)401-408
Number of pages8
JournalHeart
Volume99
Issue number6
DOIs
Publication statusPublished - Feb 2013
Externally publishedYes

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Athletes
Sports
Cardiology
Cardiomyopathies
France
Cross-Sectional Studies
Outcome Assessment (Health Care)

Cite this

Gati, Sabiha ; Chandra, Navin ; Bennett, Rachel Louise ; Reed, Matt ; Kervio, Gaelle ; Panoulas, Vasileios F. ; Ghani, Saqib ; Sheikh, Nabeel ; Zaidi, Abbas ; Wilson, Matthew ; Papadakis, Michael ; Carré, Francois ; Sharma, Sanjay. / Increased left ventricular trabeculation in highly trained athletes : Do we need more stringent criteria for the diagnosis of left ventricular non-compaction in athletes?. In: Heart. 2013 ; Vol. 99, No. 6. pp. 401-408.
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title = "Increased left ventricular trabeculation in highly trained athletes: Do we need more stringent criteria for the diagnosis of left ventricular non-compaction in athletes?",
abstract = "Objective To investigate the prevalence and significance of increased left ventricular (LV) trabeculation in highly trained athletes. Design Cross sectional echocardiographic study. Setting Sports cardiology institutions in the UK and France. Subjects 1146 athletes aged 14-35 years (63.3{\%} male), participating in 27 sporting disciplines, and 415 healthy controls of similar age. The results of athletes fulfilling conventional criteria for LV non-compaction (LVNC) were compared with 75 patients with LVNC. Main outcome measure Number of athletes with increased LV trabeculation and the number fulfilling criteria for LVNC. Results Athletes displayed a higher prevalence of increased LV trabeculation compared with controls (18.3{\%} vs 7.0{\%}; p≤0.0001) and 8.1{\%} athletes fulfilled conventional criteria for LVNC. Increased LV trabeculation were more common in athletes of African/Afro-Caribbean origin. A small proportion of athletes (n=10; 0.9{\%}) revealed reduced systolic function and marked repolarisation changes in association with echocardiographic criteria for LVNC raising the possibility of an underlying cardiomyopathy. Follow-up during the ensuing 48.6±14.6 months did not reveal adverse events. Conclusions A high proportion of young athletes exhibit conventional criteria for LVNC highlighting the non-specific nature of current diagnostic criteria if applied to elite athletic populations. Further assessment of such athletes should be confined to the small minority that demonstrate low indices of systolic function and marked repolarisation changes.",
author = "Sabiha Gati and Navin Chandra and Bennett, {Rachel Louise} and Matt Reed and Gaelle Kervio and Panoulas, {Vasileios F.} and Saqib Ghani and Nabeel Sheikh and Abbas Zaidi and Matthew Wilson and Michael Papadakis and Francois Carr{\'e} and Sanjay Sharma",
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doi = "10.1136/heartjnl-2012-303418",
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Gati, S, Chandra, N, Bennett, RL, Reed, M, Kervio, G, Panoulas, VF, Ghani, S, Sheikh, N, Zaidi, A, Wilson, M, Papadakis, M, Carré, F & Sharma, S 2013, 'Increased left ventricular trabeculation in highly trained athletes: Do we need more stringent criteria for the diagnosis of left ventricular non-compaction in athletes?', Heart, vol. 99, no. 6, pp. 401-408. https://doi.org/10.1136/heartjnl-2012-303418

Increased left ventricular trabeculation in highly trained athletes : Do we need more stringent criteria for the diagnosis of left ventricular non-compaction in athletes? / Gati, Sabiha; Chandra, Navin; Bennett, Rachel Louise; Reed, Matt; Kervio, Gaelle; Panoulas, Vasileios F.; Ghani, Saqib; Sheikh, Nabeel; Zaidi, Abbas; Wilson, Matthew; Papadakis, Michael; Carré, Francois; Sharma, Sanjay.

In: Heart, Vol. 99, No. 6, 02.2013, p. 401-408.

Research output: Contribution to journalArticle

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T1 - Increased left ventricular trabeculation in highly trained athletes

T2 - Do we need more stringent criteria for the diagnosis of left ventricular non-compaction in athletes?

AU - Gati, Sabiha

AU - Chandra, Navin

AU - Bennett, Rachel Louise

AU - Reed, Matt

AU - Kervio, Gaelle

AU - Panoulas, Vasileios F.

AU - Ghani, Saqib

AU - Sheikh, Nabeel

AU - Zaidi, Abbas

AU - Wilson, Matthew

AU - Papadakis, Michael

AU - Carré, Francois

AU - Sharma, Sanjay

PY - 2013/2

Y1 - 2013/2

N2 - Objective To investigate the prevalence and significance of increased left ventricular (LV) trabeculation in highly trained athletes. Design Cross sectional echocardiographic study. Setting Sports cardiology institutions in the UK and France. Subjects 1146 athletes aged 14-35 years (63.3% male), participating in 27 sporting disciplines, and 415 healthy controls of similar age. The results of athletes fulfilling conventional criteria for LV non-compaction (LVNC) were compared with 75 patients with LVNC. Main outcome measure Number of athletes with increased LV trabeculation and the number fulfilling criteria for LVNC. Results Athletes displayed a higher prevalence of increased LV trabeculation compared with controls (18.3% vs 7.0%; p≤0.0001) and 8.1% athletes fulfilled conventional criteria for LVNC. Increased LV trabeculation were more common in athletes of African/Afro-Caribbean origin. A small proportion of athletes (n=10; 0.9%) revealed reduced systolic function and marked repolarisation changes in association with echocardiographic criteria for LVNC raising the possibility of an underlying cardiomyopathy. Follow-up during the ensuing 48.6±14.6 months did not reveal adverse events. Conclusions A high proportion of young athletes exhibit conventional criteria for LVNC highlighting the non-specific nature of current diagnostic criteria if applied to elite athletic populations. Further assessment of such athletes should be confined to the small minority that demonstrate low indices of systolic function and marked repolarisation changes.

AB - Objective To investigate the prevalence and significance of increased left ventricular (LV) trabeculation in highly trained athletes. Design Cross sectional echocardiographic study. Setting Sports cardiology institutions in the UK and France. Subjects 1146 athletes aged 14-35 years (63.3% male), participating in 27 sporting disciplines, and 415 healthy controls of similar age. The results of athletes fulfilling conventional criteria for LV non-compaction (LVNC) were compared with 75 patients with LVNC. Main outcome measure Number of athletes with increased LV trabeculation and the number fulfilling criteria for LVNC. Results Athletes displayed a higher prevalence of increased LV trabeculation compared with controls (18.3% vs 7.0%; p≤0.0001) and 8.1% athletes fulfilled conventional criteria for LVNC. Increased LV trabeculation were more common in athletes of African/Afro-Caribbean origin. A small proportion of athletes (n=10; 0.9%) revealed reduced systolic function and marked repolarisation changes in association with echocardiographic criteria for LVNC raising the possibility of an underlying cardiomyopathy. Follow-up during the ensuing 48.6±14.6 months did not reveal adverse events. Conclusions A high proportion of young athletes exhibit conventional criteria for LVNC highlighting the non-specific nature of current diagnostic criteria if applied to elite athletic populations. Further assessment of such athletes should be confined to the small minority that demonstrate low indices of systolic function and marked repolarisation changes.

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SN - 1355-6037

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