Abstract
Greater trochanteric pain syndrome (GTPS) is a pathology that can involve the trochanteric bursa or the tendons which attach to the greater trochanter. To clarify the potential importance of bursa versus tendon pathology and of substance P (SP) in contributing to pain in this condition tendon and bursa tissue biopsies were obtained from 34 patients with GTPS and 29 control subjects. Specimens were evaluated via light microscopy for histopathological and morphological differences, as well as using immunohistochemistry for macrophages (CD68), inflammatory cells (CD45) and SP. Bursa [stroma score, mean (SD): 4.18 (1.65) vs. 2.53 (1.61), p = 0.051] and tendon [Bonar score, mean (SD): GTPS mean (SD) 12.65 (2.0), control (10.43 (4.84), p = 0.04] from subjects with GTPS demonstrated more extensive signs of pathology than specimens from control subjects. There was a significantly greater presence of SP in the bursa (frequency: 9/12 vs. 6/16, p = 0.047), but not in the tendon (8/12 vs. 8/15, p = 0.484) of subjects with GTPS compared to controls. An increased presence of SP in the trochanteric bursa may be related to the pain associated with GTPS.
| Original language | English |
|---|---|
| Pages (from-to) | 1441-1448 |
| Number of pages | 8 |
| Journal | Rheumatology International |
| Volume | 34 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 24 Sep 2014 |
| Externally published | Yes |
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Increased substance P expression in the trochanteric bursa of patients with greater trochanteric pain syndrome. / FEARON, Angie; Twin, Jane; Dahlstrom, Jane; Cook, Jill; Cormick, Wes; Smith, Paul; Scott, Alexander.
In: Rheumatology International, Vol. 34, No. 10, 24.09.2014, p. 1441-1448.Research output: Contribution to journal › Article
TY - JOUR
T1 - Increased substance P expression in the trochanteric bursa of patients with greater trochanteric pain syndrome
AU - FEARON, Angie
AU - Twin, Jane
AU - Dahlstrom, Jane
AU - Cook, Jill
AU - Cormick, Wes
AU - Smith, Paul
AU - Scott, Alexander
PY - 2014/9/24
Y1 - 2014/9/24
N2 - Greater trochanteric pain syndrome (GTPS) is a pathology that can involve the trochanteric bursa or the tendons which attach to the greater trochanter. To clarify the potential importance of bursa versus tendon pathology and of substance P (SP) in contributing to pain in this condition tendon and bursa tissue biopsies were obtained from 34 patients with GTPS and 29 control subjects. Specimens were evaluated via light microscopy for histopathological and morphological differences, as well as using immunohistochemistry for macrophages (CD68), inflammatory cells (CD45) and SP. Bursa [stroma score, mean (SD): 4.18 (1.65) vs. 2.53 (1.61), p = 0.051] and tendon [Bonar score, mean (SD): GTPS mean (SD) 12.65 (2.0), control (10.43 (4.84), p = 0.04] from subjects with GTPS demonstrated more extensive signs of pathology than specimens from control subjects. There was a significantly greater presence of SP in the bursa (frequency: 9/12 vs. 6/16, p = 0.047), but not in the tendon (8/12 vs. 8/15, p = 0.484) of subjects with GTPS compared to controls. An increased presence of SP in the trochanteric bursa may be related to the pain associated with GTPS.
AB - Greater trochanteric pain syndrome (GTPS) is a pathology that can involve the trochanteric bursa or the tendons which attach to the greater trochanter. To clarify the potential importance of bursa versus tendon pathology and of substance P (SP) in contributing to pain in this condition tendon and bursa tissue biopsies were obtained from 34 patients with GTPS and 29 control subjects. Specimens were evaluated via light microscopy for histopathological and morphological differences, as well as using immunohistochemistry for macrophages (CD68), inflammatory cells (CD45) and SP. Bursa [stroma score, mean (SD): 4.18 (1.65) vs. 2.53 (1.61), p = 0.051] and tendon [Bonar score, mean (SD): GTPS mean (SD) 12.65 (2.0), control (10.43 (4.84), p = 0.04] from subjects with GTPS demonstrated more extensive signs of pathology than specimens from control subjects. There was a significantly greater presence of SP in the bursa (frequency: 9/12 vs. 6/16, p = 0.047), but not in the tendon (8/12 vs. 8/15, p = 0.484) of subjects with GTPS compared to controls. An increased presence of SP in the trochanteric bursa may be related to the pain associated with GTPS.
KW - Bursitis
KW - Histopathology
KW - Lateral hip pain
KW - Osteoarthritis
KW - Tendinopathy
KW - Prospective Studies
KW - Humans
KW - Bursa, Synovial/metabolism
KW - Substance P/metabolism
KW - Tendons/metabolism
KW - Biopsy
KW - Female
KW - Retrospective Studies
KW - Femur/metabolism
KW - Pain/metabolism
UR - http://www.scopus.com/inward/record.url?scp=84918803719&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/increased-substance-p-expression-trochanteric-bursa-patients-greater-trochanteric-pain-syndrome-1
U2 - 10.1007/s00296-014-2957-7
DO - 10.1007/s00296-014-2957-7
M3 - Article
VL - 34
SP - 1441
EP - 1448
JO - Rheumatology International
JF - Rheumatology International
SN - 0172-8172
IS - 10
ER -