Increased substance P expression in the trochanteric bursa of patients with greater trochanteric pain syndrome

Angie FEARON, Jane Twin, Jane Dahlstrom, Jill Cook, Wes Cormick, Paul Smith, Alexander Scott

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15 Citations (Scopus)

Abstract

Greater trochanteric pain syndrome (GTPS) is a pathology that can involve the trochanteric bursa or the tendons which attach to the greater trochanter. To clarify the potential importance of bursa versus tendon pathology and of substance P (SP) in contributing to pain in this condition tendon and bursa tissue biopsies were obtained from 34 patients with GTPS and 29 control subjects. Specimens were evaluated via light microscopy for histopathological and morphological differences, as well as using immunohistochemistry for macrophages (CD68), inflammatory cells (CD45) and SP. Bursa [stroma score, mean (SD): 4.18 (1.65) vs. 2.53 (1.61), p = 0.051] and tendon [Bonar score, mean (SD): GTPS mean (SD) 12.65 (2.0), control (10.43 (4.84), p = 0.04] from subjects with GTPS demonstrated more extensive signs of pathology than specimens from control subjects. There was a significantly greater presence of SP in the bursa (frequency: 9/12 vs. 6/16, p = 0.047), but not in the tendon (8/12 vs. 8/15, p = 0.484) of subjects with GTPS compared to controls. An increased presence of SP in the trochanteric bursa may be related to the pain associated with GTPS.

Original languageEnglish
Pages (from-to)1441-1448
Number of pages8
JournalRheumatology International
Volume34
Issue number10
DOIs
Publication statusPublished - 24 Sep 2014
Externally publishedYes

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Substance P
Pain
Tendons
Pathology
Femur
Microscopy
Immunohistochemistry
Macrophages
Biopsy
Light

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FEARON, Angie ; Twin, Jane ; Dahlstrom, Jane ; Cook, Jill ; Cormick, Wes ; Smith, Paul ; Scott, Alexander. / Increased substance P expression in the trochanteric bursa of patients with greater trochanteric pain syndrome. In: Rheumatology International. 2014 ; Vol. 34, No. 10. pp. 1441-1448.
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Increased substance P expression in the trochanteric bursa of patients with greater trochanteric pain syndrome. / FEARON, Angie; Twin, Jane; Dahlstrom, Jane; Cook, Jill; Cormick, Wes; Smith, Paul; Scott, Alexander.

In: Rheumatology International, Vol. 34, No. 10, 24.09.2014, p. 1441-1448.

Research output: Contribution to journalArticle

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T1 - Increased substance P expression in the trochanteric bursa of patients with greater trochanteric pain syndrome

AU - FEARON, Angie

AU - Twin, Jane

AU - Dahlstrom, Jane

AU - Cook, Jill

AU - Cormick, Wes

AU - Smith, Paul

AU - Scott, Alexander

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AB - Greater trochanteric pain syndrome (GTPS) is a pathology that can involve the trochanteric bursa or the tendons which attach to the greater trochanter. To clarify the potential importance of bursa versus tendon pathology and of substance P (SP) in contributing to pain in this condition tendon and bursa tissue biopsies were obtained from 34 patients with GTPS and 29 control subjects. Specimens were evaluated via light microscopy for histopathological and morphological differences, as well as using immunohistochemistry for macrophages (CD68), inflammatory cells (CD45) and SP. Bursa [stroma score, mean (SD): 4.18 (1.65) vs. 2.53 (1.61), p = 0.051] and tendon [Bonar score, mean (SD): GTPS mean (SD) 12.65 (2.0), control (10.43 (4.84), p = 0.04] from subjects with GTPS demonstrated more extensive signs of pathology than specimens from control subjects. There was a significantly greater presence of SP in the bursa (frequency: 9/12 vs. 6/16, p = 0.047), but not in the tendon (8/12 vs. 8/15, p = 0.484) of subjects with GTPS compared to controls. An increased presence of SP in the trochanteric bursa may be related to the pain associated with GTPS.

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KW - Pain/metabolism

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