Influence of demand-side measures to enhance renin-angiotensin prescribing efficiency in Europe: Implications for the future

Luka Voncina, Tihomir Strizrep, Brian Godman, Marion Bennie, Iain Bishop, Stephen Campbell, Vera Vlahovic-Palcevski, Lars L. Gustafsson

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

European countries strive to enhance prescribing efficiency. This includes renin-angiotensin drugs following the availability of generic angiotensin-converting enzyme inhibitors (ACEIs). Aims: To compare angiotensin receptor blocker utilization and expenditure patterns in Austria and Croatia following prescribing restrictions, as well as with other European countries introducing different supply- and demand-side measures. Lastly, to appraise the impact of generic losartan in Croatia on utilization of patented angiotensin receptor blockers. Method: Observational retrospective study principally between 2001 and 2007, using defined daily doses and (sic)/1000 inhabitants/year. Demand-side measures were based on the four 'E's-education, engineering, economics and enforcement. Results: Greater intensity of follow-up of prescribing restrictions in Croatia enhanced utilization of ACEIs versus Austria. There was high utilization of ACEIs in Scotland following intensive demand-side measures, similar to Austria and Croatia. Demand-side measures in Spain (Catalonia) and Sweden also appeared to moderate angiotensin receptor blockers utilization. The combination of measures helped stabilize expenditure on renin-angiotensin drugs when adjusted for population sizes despite appreciable increases in volumes. The only exception was Portugal, with less intensive measures. Conclusion: Multiple and intensive demand-side measures enhanced prescribing efficiency. The more intense follow-up of ARB prescribing restrictions in Croatia had a greater influence on subsequent utilization patterns than Austria. Both findings confirm earlier studies. Reforms also favorably enhanced the prescribing of generic losartan once available
Original languageEnglish
Pages (from-to)469-479
Number of pages11
JournalExpert Review of Pharmacoeconomics Outcomes Research
Volume11
Issue number4
DOIs
Publication statusPublished - 2011
Externally publishedYes

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Croatia
Angiotensins
Renin
Austria
Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors
Losartan
Health Expenditures
Portugal
Scotland
Population Density
Sweden
Pharmaceutical Preparations
Spain
Observational Studies
Retrospective Studies
Economics
Education

Cite this

Voncina, Luka ; Strizrep, Tihomir ; Godman, Brian ; Bennie, Marion ; Bishop, Iain ; Campbell, Stephen ; Vlahovic-Palcevski, Vera ; Gustafsson, Lars L. / Influence of demand-side measures to enhance renin-angiotensin prescribing efficiency in Europe: Implications for the future. In: Expert Review of Pharmacoeconomics Outcomes Research. 2011 ; Vol. 11, No. 4. pp. 469-479.
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Voncina, L, Strizrep, T, Godman, B, Bennie, M, Bishop, I, Campbell, S, Vlahovic-Palcevski, V & Gustafsson, LL 2011, 'Influence of demand-side measures to enhance renin-angiotensin prescribing efficiency in Europe: Implications for the future', Expert Review of Pharmacoeconomics Outcomes Research, vol. 11, no. 4, pp. 469-479. https://doi.org/10.1586/erp.11.42

Influence of demand-side measures to enhance renin-angiotensin prescribing efficiency in Europe: Implications for the future. / Voncina, Luka; Strizrep, Tihomir; Godman, Brian; Bennie, Marion; Bishop, Iain; Campbell, Stephen; Vlahovic-Palcevski, Vera; Gustafsson, Lars L.

In: Expert Review of Pharmacoeconomics Outcomes Research, Vol. 11, No. 4, 2011, p. 469-479.

Research output: Contribution to journalArticle

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