TY - JOUR
T1 - Influence of exercise intensity and duration on functional and biochemical perturbations in the human heart
AU - Stewart, Glenn
AU - Yamada, Akira
AU - Haseler, Luke
AU - Kavanagh, Justin
AU - Chan, Jonathan
AU - KOERBIN, Gus
AU - Wood, Cameron
AU - Sabapathy, Surendran
N1 - © 2016 The Authors. The Journal of Physiology © 2016 The Physiological Society.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Strenuous endurance exercise induces transient cardiac perturbations with ambiguous health outcomes. The present study investigated the magnitude and time‐course of exercise‐induced functional and biochemical cardiac perturbations by manipulating the exercise intensity–duration matrix. Echocardiograph‐derived left (LV) and right (RV) ventricular global longitudinal strain (GLS), and serum high‐sensitivity cardiac troponin (hs‐cTnI) concentration, were examined in 10 males (age: 27 ± 4 years; urn:x-wiley:00223751:media:tjp7084:tjp7084-math-0001: 4.0 ± 0.8 l min−1) before, throughout (50%, 75% and 100%), and during recovery (1, 3, 6 and 24 h) from two exercise trials. The two exercise trials consisted of 90 and 120 min of heavy‐ and moderate‐intensity cycling, respectively, with total mechanical work matched. LVGLS decreased (P < 0.01) during the 90 min trial only, with reductions peaking at 1 h post (pre: −19.9 ± 0.6%; 1 h post: −18.5 ± 0.7%) and persisting for >24 h into recovery. RVGLS decreased (P < 0.05) during both exercise trials with reductions in the 90 min trial peaking at 1 h post (pre: −27.5 ± 0.7%; 1 h post: −25.1 ± 0.8%) and persisting for >24 h into recovery. Serum hs‐cTnI increased (P < 0.01) during both exercise trials, with concentrations peaking at 3 h post but only exceeding cardio‐healthy reference limits (14 ng l−1) in the 90 min trial (pre: 4.2 ± 2.4 ng l−1; 3 h post: 25.1 ± 7.9 ng l−1). Exercise‐induced reductions in ventricular strain and increases in cardiac injury markers persist for 24 h following exercise that is typical of day‐to‐day endurance exercise training; however, the magnitude and time‐course of this response can be altered by manipulating the intensity–duration matrix.
AB - Strenuous endurance exercise induces transient cardiac perturbations with ambiguous health outcomes. The present study investigated the magnitude and time‐course of exercise‐induced functional and biochemical cardiac perturbations by manipulating the exercise intensity–duration matrix. Echocardiograph‐derived left (LV) and right (RV) ventricular global longitudinal strain (GLS), and serum high‐sensitivity cardiac troponin (hs‐cTnI) concentration, were examined in 10 males (age: 27 ± 4 years; urn:x-wiley:00223751:media:tjp7084:tjp7084-math-0001: 4.0 ± 0.8 l min−1) before, throughout (50%, 75% and 100%), and during recovery (1, 3, 6 and 24 h) from two exercise trials. The two exercise trials consisted of 90 and 120 min of heavy‐ and moderate‐intensity cycling, respectively, with total mechanical work matched. LVGLS decreased (P < 0.01) during the 90 min trial only, with reductions peaking at 1 h post (pre: −19.9 ± 0.6%; 1 h post: −18.5 ± 0.7%) and persisting for >24 h into recovery. RVGLS decreased (P < 0.05) during both exercise trials with reductions in the 90 min trial peaking at 1 h post (pre: −27.5 ± 0.7%; 1 h post: −25.1 ± 0.8%) and persisting for >24 h into recovery. Serum hs‐cTnI increased (P < 0.01) during both exercise trials, with concentrations peaking at 3 h post but only exceeding cardio‐healthy reference limits (14 ng l−1) in the 90 min trial (pre: 4.2 ± 2.4 ng l−1; 3 h post: 25.1 ± 7.9 ng l−1). Exercise‐induced reductions in ventricular strain and increases in cardiac injury markers persist for 24 h following exercise that is typical of day‐to‐day endurance exercise training; however, the magnitude and time‐course of this response can be altered by manipulating the intensity–duration matrix.
KW - Adult
KW - Biomarkers/blood
KW - Biomechanical Phenomena/physiology
KW - Blood Pressure/physiology
KW - C-Reactive Protein/metabolism
KW - Cardiac Output/physiology
KW - Echocardiography
KW - Exercise Test/methods
KW - Exercise/physiology
KW - Heart/physiology
KW - Humans
KW - Hydrocortisone/blood
KW - Male
KW - Physical Endurance/physiology
KW - Physical Exertion/physiology
KW - Random Allocation
KW - Stroke Volume/physiology
KW - Time Factors
KW - Young Adult
UR - http://www.scopus.com/inward/record.url?scp=84960346819&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/influence-exercise-intensity-duration-functional-biochemical-perturbations-human-heart
U2 - 10.1113/JP271889
DO - 10.1113/JP271889
M3 - Article
C2 - 26801350
SN - 0022-3751
VL - 594
SP - 3031
EP - 3044
JO - Journal of Physiology
JF - Journal of Physiology
IS - 11
ER -