Influence of exercise intensity and duration on functional and biochemical perturbations in the human heart

Glenn Stewart, Akira Yamada, Luke Haseler, Justin Kavanagh, Jonathan Chan, Gus KOERBIN, Cameron Wood, Surendran Sabapathy

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Abstract

Strenuous endurance exercise induces transient cardiac perturbations with ambiguous health outcomes. The present study investigated the magnitude and time‐course of exercise‐induced functional and biochemical cardiac perturbations by manipulating the exercise intensity–duration matrix. Echocardiograph‐derived left (LV) and right (RV) ventricular global longitudinal strain (GLS), and serum high‐sensitivity cardiac troponin (hs‐cTnI) concentration, were examined in 10 males (age: 27 ± 4 years; urn:x-wiley:00223751:media:tjp7084:tjp7084-math-0001: 4.0 ± 0.8 l min−1) before, throughout (50%, 75% and 100%), and during recovery (1, 3, 6 and 24 h) from two exercise trials. The two exercise trials consisted of 90 and 120 min of heavy‐ and moderate‐intensity cycling, respectively, with total mechanical work matched. LVGLS decreased (P < 0.01) during the 90 min trial only, with reductions peaking at 1 h post (pre: −19.9 ± 0.6%; 1 h post: −18.5 ± 0.7%) and persisting for >24 h into recovery. RVGLS decreased (P < 0.05) during both exercise trials with reductions in the 90 min trial peaking at 1 h post (pre: −27.5 ± 0.7%; 1 h post: −25.1 ± 0.8%) and persisting for >24 h into recovery. Serum hs‐cTnI increased (P < 0.01) during both exercise trials, with concentrations peaking at 3 h post but only exceeding cardio‐healthy reference limits (14 ng l−1) in the 90 min trial (pre: 4.2 ± 2.4 ng l−1; 3 h post: 25.1 ± 7.9 ng l−1). Exercise‐induced reductions in ventricular strain and increases in cardiac injury markers persist for 24 h following exercise that is typical of day‐to‐day endurance exercise training; however, the magnitude and time‐course of this response can be altered by manipulating the intensity–duration matrix.
Original languageEnglish
Pages (from-to)3031-3044
Number of pages14
JournalJournal of Physiology
Volume594
Issue number11
DOIs
Publication statusPublished - 1 Jun 2016

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Stewart, G., Yamada, A., Haseler, L., Kavanagh, J., Chan, J., KOERBIN, G., ... Sabapathy, S. (2016). Influence of exercise intensity and duration on functional and biochemical perturbations in the human heart. Journal of Physiology, 594(11), 3031-3044. https://doi.org/10.1113/JP271889