TY - JOUR
T1 - Influence of residential land cover on childhood allergic and respiratory symptoms and diseases
T2 - Evidence from 9 European cohorts
AU - Parmes, Eija
AU - Pesce, Giancarlo
AU - Sabel, Clive E.
AU - Baldacci, Sandra
AU - Bono, Roberto
AU - Brescianini, Sonia
AU - D'Ippolito, Cristina
AU - Hanke, Wojciech
AU - Horvat, Milena
AU - Liedes, Hilkka
AU - Maio, Sara
AU - Marchetti, Pierpaolo
AU - Marcon, Alessandro
AU - Medda, Emanuela
AU - Molinier, Matthieu
AU - Panunzi, Silvia
AU - Pärkkä, Juha
AU - Polańska, Kinga
AU - Prud'homme, Julie
AU - Ricci, Paolo
AU - Snoj Tratnik, Janja
AU - Squillacioti, Giulia
AU - Stazi, Maria Antonietta
AU - Maesano, Cara Nichole
AU - Annesi-Maesano, Isabella
N1 - Funding Information:
In addition, the following funding supported the individual cohort studies: PHIME-SLO work was supported by the EU through the 6th Framework Program ( FOOD-CT-2006-016253 , PHIME project) and the CROME-LIFE + project; the REPRO_PL cohort received financial support from the National Science Centre , Poland, under grant No. UMO-2014/15/B/NZ7/00998 ; the Pisa2 study was supported in part by the Italian National Research Council Targeted Project ‘Prevention and Control Disease Factors-SP 2’ (Contract No. 91.00171.PF41 ), by the Italian Ministry of Labour and Social Security (Contract No. 587–1997 ), and by the CNR-ENEL (Italian Electric Power Authority) ‘Interaction of Energy Systems with Human Health and Environment’ Project (1989). ITR was funded by the Italian Ministry of Health . MUBICOs has been partly funded by an unrestricted grant by the Chiesi Foundation (Parma, Italy). The Turin study was made possible by a grant of the University of Turin to Roberto Bono (ex 60% 2013) and a grant of Regione Piemonte to Pavilio Piccioni (Ricerca finalizzata 2011). The Viadana study was funded by the local National Institutes of Health (Asl Mantova) and by the province of Mantua. The Fumane study was funded by the municipality of Fumane.
Funding Information:
This study was carried out within the HEALS project (2013–2019) which has received funding from the European Union's Seventh Framework Programme for Research, technological development and demonstration under grant agreement FP7-ENV-2013- 603946 .
Funding Information:
EDEN was supported by the Foundation for Medical Research (FRM), National Agency for Research (ANR), National Institute for Research in Public Health (IRESP: TGIR cohorte santé 2008 program), French Ministry of Health (DGS), French Ministry of Research , INSERM Bone and Joint Diseases National Research (PRO-A) and Human Nutrition National Research Programs , Paris–Sud University, Nestlé, French National Institute for Population Health Surveillance (InVS), French National Institute for Health Education (INPES), the European Union FP7 programmes ( FP7/2007–2013 , HELIX, ESCAPE, ENRIECO, Medall projects), Diabetes National Research Program (through a collaboration with the French Association of Diabetic Patients (AFD)), French Agency for Environmental Health Safety (now ANSES ), Mutuelle Générale de l’Education Nationale (MGEN), French National Agency for Food Security , and the French-speaking association for the study of diabetes and metabolism (ALFEDIAM).
Funding Information:
This study was carried out within the HEALS project (2013?2019) which has received funding from the European Union's Seventh Framework Programme for Research, technological development and demonstration under grant agreement FP7-ENV-2013-603946.In addition, the following funding supported the individual cohort studies: PHIME-SLO work was supported by the EU through the 6th Framework Program (FOOD-CT-2006-016253, PHIME project) and the CROME-LIFE + project; the REPRO_PL cohort received financial support from the National Science Centre, Poland, under grant No. UMO-2014/15/B/NZ7/00998; the Pisa2 study was supported in part by the Italian National Research Council Targeted Project ?Prevention and Control Disease Factors-SP 2? (Contract No. 91.00171.PF41), by the Italian Ministry of Labour and Social Security (Contract No. 587?1997), and by the CNR-ENEL (Italian Electric Power Authority) ?Interaction of Energy Systems with Human Health and Environment? Project (1989). ITR was funded by the Italian Ministry of Health. MUBICOs has been partly funded by an unrestricted grant by the Chiesi Foundation (Parma, Italy). The Turin study was made possible by a grant of the University of Turin to Roberto Bono (ex 60% 2013) and a grant of Regione Piemonte to Pavilio Piccioni (Ricerca finalizzata 2011). The Viadana study was funded by the local National Institutes of Health (Asl Mantova) and by the province of Mantua. The Fumane study was funded by the municipality of Fumane.EDEN was supported by the Foundation for Medical Research (FRM), National Agency for Research (ANR), National Institute for Research in Public Health (IRESP: TGIR cohorte sant? 2008 program), French Ministry of Health (DGS), French Ministry of Research, INSERM Bone and Joint Diseases National Research (PRO-A) and Human Nutrition National Research Programs, Paris?Sud University, Nestl?, French National Institute for Population Health Surveillance (InVS), French National Institute for Health Education (INPES), the European Union FP7 programmes (FP7/2007?2013, HELIX, ESCAPE, ENRIECO, Medall projects), Diabetes National Research Program (through a collaboration with the French Association of Diabetic Patients (AFD)), French Agency for Environmental Health Safety (now ANSES), Mutuelle G?n?rale de l'Education Nationale (MGEN), French National Agency for Food Security, and the French-speaking association for the study of diabetes and metabolism (ALFEDIAM).
Publisher Copyright:
© 2019 The Authors
PY - 2020/4
Y1 - 2020/4
N2 - Introduction: Recent research focused on the interaction between land cover and the development of allergic and respiratory disease has provided conflicting results and the underlying mechanisms are not fully understood. In particular, green space, which confers an overall positive impact on general health, may be significantly contributing to adverse respiratory health outcomes. This study evaluates associations between surrounding residential land cover (green, grey, agricultural and blue space), including type of forest cover (deciduous, coniferous and mixed), and childhood allergic and respiratory diseases. Methods: Data from 8063 children, aged 3–14 years, were obtained from nine European population-based studies participating in the HEALS project. Land-cover exposures within a 500 m buffer centred on each child's residential address were computed using data from the Coordination of Information on the Environment (CORINE) program. The associations of allergic and respiratory symptoms (wheeze, asthma, allergic rhinitis and eczema) with land coverage were estimated for each study using logistic regression models, adjusted for sex, age, body mass index, maternal education, parental smoking, and parental history of allergy. Finally, the pooled effects across studies were estimated using meta-analyses. Results: In the pooled analyses, a 10% increase in green space coverage was significantly associated with a 5.9%–13.0% increase in the odds of wheezing, asthma, and allergic rhinitis, but not eczema. A trend of an inverse relationship between agricultural space and respiratory symptoms was observed, but did not reach statistical significance. In secondary analyses, children living in areas with surrounding coniferous forests had significantly greater odds of reporting wheezing, asthma and allergic rhinitis. Conclusion: Our results provide further evidence that exposure to green space is associated with increased respiratory disease in children. Additionally, our findings suggest that coniferous forests might be associated with wheezing, asthma and allergic rhinitis. Additional studies evaluating both the type of green space and its use in relation to respiratory conditions should be conducted in order to clarify the underlying mechanisms behind associated adverse impacts.
AB - Introduction: Recent research focused on the interaction between land cover and the development of allergic and respiratory disease has provided conflicting results and the underlying mechanisms are not fully understood. In particular, green space, which confers an overall positive impact on general health, may be significantly contributing to adverse respiratory health outcomes. This study evaluates associations between surrounding residential land cover (green, grey, agricultural and blue space), including type of forest cover (deciduous, coniferous and mixed), and childhood allergic and respiratory diseases. Methods: Data from 8063 children, aged 3–14 years, were obtained from nine European population-based studies participating in the HEALS project. Land-cover exposures within a 500 m buffer centred on each child's residential address were computed using data from the Coordination of Information on the Environment (CORINE) program. The associations of allergic and respiratory symptoms (wheeze, asthma, allergic rhinitis and eczema) with land coverage were estimated for each study using logistic regression models, adjusted for sex, age, body mass index, maternal education, parental smoking, and parental history of allergy. Finally, the pooled effects across studies were estimated using meta-analyses. Results: In the pooled analyses, a 10% increase in green space coverage was significantly associated with a 5.9%–13.0% increase in the odds of wheezing, asthma, and allergic rhinitis, but not eczema. A trend of an inverse relationship between agricultural space and respiratory symptoms was observed, but did not reach statistical significance. In secondary analyses, children living in areas with surrounding coniferous forests had significantly greater odds of reporting wheezing, asthma and allergic rhinitis. Conclusion: Our results provide further evidence that exposure to green space is associated with increased respiratory disease in children. Additionally, our findings suggest that coniferous forests might be associated with wheezing, asthma and allergic rhinitis. Additional studies evaluating both the type of green space and its use in relation to respiratory conditions should be conducted in order to clarify the underlying mechanisms behind associated adverse impacts.
KW - Allergy
KW - Asthma
KW - Forests
KW - Green space
KW - Land cover
UR - http://www.scopus.com/inward/record.url?scp=85076239973&partnerID=8YFLogxK
U2 - 10.1016/j.envres.2019.108953
DO - 10.1016/j.envres.2019.108953
M3 - Article
C2 - 31818476
AN - SCOPUS:85076239973
SN - 0013-9351
VL - 183
SP - 1
EP - 10
JO - Environmental Research
JF - Environmental Research
M1 - 108953
ER -