Influence of ultra-endurance exercise on immunoglobulin isotypes and subclasses

A J McKune; L L Smith; S J Semple; A A Wadee

doi:10.1136/bjsm.2004.017194

Influence of ultra-endurance exercise on immunoglobulin isotypes and subclasses

A J McKune, L L Smith, S J Semple, A A Wadee

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

BACKGROUND: Strenuous exercise is associated with tissue damage. This activates the innate immune system and local inflammation. Interaction between innate and adaptive immunity is essential for maintaining health, suggesting that the adaptive immune system may also be altered by exercise.

OBJECTIVES: To determine exercise induced changes in the adaptive immune system by measuring the immunoglobulin isotype and subclass response to an ultra-marathon.

METHODS: Venepuncture was performed on 11 experienced volunteers (six men, five women; mean (SD) age 43 (9.8) years) 24 hours before the projected finishing time and immediately after and 3, 24, and 72 hours after an ultra-marathon (90 km). Serum was stored at -80 degrees C. IgM, IgD, IgA, IgG, IgG1, 2, 3, and 4, and total IgE were measured.

RESULTS: The following immunoglobulins were significantly (p< or =0.05) altered after the race: IgD, immediately (-51%) and 24 hours (-41%) after; IgM 24 hours after (-23%); total IgG immediately after (+12%). There were no reports of symptoms of upper respiratory tract infections after the ultra-marathon.

CONCLUSIONS: In experienced ultra-endurance runners, alterations in immunoglobulin concentrations after a race suggest an enhanced immune response, including isotype switching, interactions with the innate immune system, and a secondary antibody response. These alterations may have a role in the maintenance of subject health after an ultra-marathon.

Original language	English
Pages (from-to)	665-70
Number of pages	6
Journal	British Journal of Sports Medicine
Volume	39
Issue number	9
DOIs	https://doi.org/10.1136/bjsm.2004.017194
Publication status	Published - Sept 2005
Externally published	Yes

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title = "Influence of ultra-endurance exercise on immunoglobulin isotypes and subclasses",

abstract = "BACKGROUND: Strenuous exercise is associated with tissue damage. This activates the innate immune system and local inflammation. Interaction between innate and adaptive immunity is essential for maintaining health, suggesting that the adaptive immune system may also be altered by exercise.OBJECTIVES: To determine exercise induced changes in the adaptive immune system by measuring the immunoglobulin isotype and subclass response to an ultra-marathon.METHODS: Venepuncture was performed on 11 experienced volunteers (six men, five women; mean (SD) age 43 (9.8) years) 24 hours before the projected finishing time and immediately after and 3, 24, and 72 hours after an ultra-marathon (90 km). Serum was stored at -80 degrees C. IgM, IgD, IgA, IgG, IgG1, 2, 3, and 4, and total IgE were measured.RESULTS: The following immunoglobulins were significantly (p< or =0.05) altered after the race: IgD, immediately (-51%) and 24 hours (-41%) after; IgM 24 hours after (-23%); total IgG immediately after (+12%). There were no reports of symptoms of upper respiratory tract infections after the ultra-marathon.CONCLUSIONS: In experienced ultra-endurance runners, alterations in immunoglobulin concentrations after a race suggest an enhanced immune response, including isotype switching, interactions with the innate immune system, and a secondary antibody response. These alterations may have a role in the maintenance of subject health after an ultra-marathon.",

keywords = "Adult, Body Composition, Exercise, Female, Heart Rate, Humans, Immunoglobulin Isotypes, Male, Middle Aged, Oxygen Consumption, Physical Endurance, Running, Journal Article",

author = "McKune, {A J} and Smith, {L L} and Semple, {S J} and Wadee, {A A}",

year = "2005",

month = sep,

doi = "10.1136/bjsm.2004.017194",

language = "English",

volume = "39",

pages = "665--70",

journal = "British Journal of Sports Medicine",

issn = "0306-3674",

publisher = "BMJ Publishing Group",

number = "9",

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T1 - Influence of ultra-endurance exercise on immunoglobulin isotypes and subclasses

AU - McKune, A J

AU - Smith, L L

AU - Semple, S J

AU - Wadee, A A

PY - 2005/9

Y1 - 2005/9

N2 - BACKGROUND: Strenuous exercise is associated with tissue damage. This activates the innate immune system and local inflammation. Interaction between innate and adaptive immunity is essential for maintaining health, suggesting that the adaptive immune system may also be altered by exercise.OBJECTIVES: To determine exercise induced changes in the adaptive immune system by measuring the immunoglobulin isotype and subclass response to an ultra-marathon.METHODS: Venepuncture was performed on 11 experienced volunteers (six men, five women; mean (SD) age 43 (9.8) years) 24 hours before the projected finishing time and immediately after and 3, 24, and 72 hours after an ultra-marathon (90 km). Serum was stored at -80 degrees C. IgM, IgD, IgA, IgG, IgG1, 2, 3, and 4, and total IgE were measured.RESULTS: The following immunoglobulins were significantly (p< or =0.05) altered after the race: IgD, immediately (-51%) and 24 hours (-41%) after; IgM 24 hours after (-23%); total IgG immediately after (+12%). There were no reports of symptoms of upper respiratory tract infections after the ultra-marathon.CONCLUSIONS: In experienced ultra-endurance runners, alterations in immunoglobulin concentrations after a race suggest an enhanced immune response, including isotype switching, interactions with the innate immune system, and a secondary antibody response. These alterations may have a role in the maintenance of subject health after an ultra-marathon.

AB - BACKGROUND: Strenuous exercise is associated with tissue damage. This activates the innate immune system and local inflammation. Interaction between innate and adaptive immunity is essential for maintaining health, suggesting that the adaptive immune system may also be altered by exercise.OBJECTIVES: To determine exercise induced changes in the adaptive immune system by measuring the immunoglobulin isotype and subclass response to an ultra-marathon.METHODS: Venepuncture was performed on 11 experienced volunteers (six men, five women; mean (SD) age 43 (9.8) years) 24 hours before the projected finishing time and immediately after and 3, 24, and 72 hours after an ultra-marathon (90 km). Serum was stored at -80 degrees C. IgM, IgD, IgA, IgG, IgG1, 2, 3, and 4, and total IgE were measured.RESULTS: The following immunoglobulins were significantly (p< or =0.05) altered after the race: IgD, immediately (-51%) and 24 hours (-41%) after; IgM 24 hours after (-23%); total IgG immediately after (+12%). There were no reports of symptoms of upper respiratory tract infections after the ultra-marathon.CONCLUSIONS: In experienced ultra-endurance runners, alterations in immunoglobulin concentrations after a race suggest an enhanced immune response, including isotype switching, interactions with the innate immune system, and a secondary antibody response. These alterations may have a role in the maintenance of subject health after an ultra-marathon.

KW - Adult

KW - Body Composition

KW - Exercise

KW - Female

KW - Heart Rate

KW - Humans

KW - Immunoglobulin Isotypes

KW - Male

KW - Middle Aged

KW - Oxygen Consumption

KW - Physical Endurance

KW - Running

KW - Journal Article

U2 - 10.1136/bjsm.2004.017194

DO - 10.1136/bjsm.2004.017194

M3 - Article

C2 - 16118307

SN - 0306-3674

VL - 39

SP - 665

EP - 670

JO - British Journal of Sports Medicine

JF - British Journal of Sports Medicine

IS - 9

ER -

Influence of ultra-endurance exercise on immunoglobulin isotypes and subclasses

Abstract

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