Insights into social insects from the genome of the honeybee Apis mellifera

The Honeybee Genome Sequencing Consortium, Anita M. Collins, Robert Kucharski

Research output: Contribution to journalArticle

1234 Citations (Scopus)

Abstract

Here we report the genome sequence of the honeybee Apis mellifera, a key model for social behaviour and essential to global ecology through pollination. Compared with other sequenced insect genomes, the A. mellifera genome has high A+T and CpG contents, lacks major transposon families, evolves more slowly, and is more similar to vertebrates for circadian rhythm, RNA interference and DNA methylation genes, among others. Furthermore, A. mellifera has fewer genes for innate immunity, detoxification enzymes, cuticle-forming proteins and gustatory receptors, more genes for odorant receptors, and novel genes for nectar and pollen utilization, consistent with its ecology and social organization. Compared to Drosophila, genes in early developmental pathways differ in Apis, whereas similarities exist for functions that differ markedly, such as sex determination, brain function and behaviour. Population genetics suggests a novel African origin for the species A. mellifera and insights into whether Africanized bees spread throughout the New World via hybridization or displacement.

Original languageEnglish
Pages (from-to)931-949
Number of pages19
JournalNature
Volume443
Issue number7114
DOIs
Publication statusPublished - 26 Oct 2006
Externally publishedYes

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Genes
Ecology
Detoxification
RNA
Brain
Enzymes
Proteins

Cite this

The Honeybee Genome Sequencing Consortium, Collins, A. M., & Kucharski, R. (2006). Insights into social insects from the genome of the honeybee Apis mellifera. Nature, 443(7114), 931-949. https://doi.org/10.1038/nature05260
The Honeybee Genome Sequencing Consortium ; Collins, Anita M. ; Kucharski, Robert. / Insights into social insects from the genome of the honeybee Apis mellifera. In: Nature. 2006 ; Vol. 443, No. 7114. pp. 931-949.
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The Honeybee Genome Sequencing Consortium, Collins, AM & Kucharski, R 2006, 'Insights into social insects from the genome of the honeybee Apis mellifera', Nature, vol. 443, no. 7114, pp. 931-949. https://doi.org/10.1038/nature05260

Insights into social insects from the genome of the honeybee Apis mellifera. / The Honeybee Genome Sequencing Consortium; Collins, Anita M.; Kucharski, Robert.

In: Nature, Vol. 443, No. 7114, 26.10.2006, p. 931-949.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Insights into social insects from the genome of the honeybee Apis mellifera

AU - The Honeybee Genome Sequencing Consortium

AU - Weinstock, George M.

AU - Robinson, Gene E.

AU - Gibbs, Richard A.

AU - Worley, Kim C.

AU - Evans, Jay D.

AU - Maleszka, Ryszard

AU - Robertson, Hugh M.

AU - Weaver, Daniel B.

AU - Beye, Martin

AU - Bork, Peer

AU - Elsik, Christine G.

AU - Hartfelder, Klaus

AU - Hunt, Greg J.

AU - Zdobnov, Evgeny M.

AU - Amdam, Gro V.

AU - Bitondi, Mrcia M.G.

AU - Collins, Anita M.

AU - Cristino, Alexandre S.

AU - Lattorff, H. Michael G.

AU - Lobo, Carlos H.

AU - Moritz, Robin F.A.

AU - Nunes, Francis M.F.

AU - Page, Robert E.

AU - Simões, Zilá L.P.

AU - Wheeler, Diana

AU - Carninci, Piero

AU - Fukuda, Shiro

AU - Hayashizaki, Yoshihide

AU - Kai, Chikatoshi

AU - Kawai, Jun

AU - Sakazume, Naoko

AU - Sasaki, Daisuke

AU - Tagami, Michihira

AU - Albert, Stefan

AU - Baggerman, Geert

AU - Beggs, Kyle T.

AU - Bloch, Guy

AU - Cazzamali, Giuseppe

AU - Cohen, Mira

AU - Drapeau, Mark David

AU - Eisenhardt, Dorothea

AU - Emore, Christine

AU - Ewing, Michael A.

AU - Fahrbach, Susan E.

AU - Forêt, Sylvain

AU - Grimmelikhuijzen, Cornelis J.P.

AU - Hauser, Frank

AU - Hummon, Amanda B.

AU - Huybrechts, Jurgen

AU - Jones, Andrew K.

AU - Kadowaki, Tatsuhiko

AU - Kaplan, Noam

AU - Kucharski, Robert

AU - Leboulle, Grard

AU - Linial, Michal

AU - Littleton, J. Troy

AU - Mercer, Alison R.

AU - Richmond, Timothy A.

AU - Rodriguez-Zas, Sandra L.

AU - Rubin, Elad B.

AU - Sattelle, David B.

AU - Schlipalius, David

AU - Schoofs, Liliane

AU - Shemesh, Yair

AU - Sweedler, Jonathan V.

AU - Velarde, Rodrigo

AU - Verleyen, Peter

AU - Vierstraete, Evy

AU - Williamson, Michael R.

AU - Ament, Seth A.

AU - Brown, Susan J.

AU - Corona, Miguel

AU - Dearden, Peter K.

AU - Dunn, W. Augustine

AU - Elekonich, Michelle M.

AU - Fujiyuki, Tomoko

AU - Gattermeier, Irene

AU - Gempe, Tanja

AU - Hasselmann, Martin

AU - Kage, Eriko

AU - Kamikouchi, Azusa

AU - Kubo, Takeo

AU - Kunieda, Takekazu

AU - Lorenzen, Marcé

AU - Milshina, Natalia V.

AU - Morioka, Mizue

AU - Ohashi, Kazuaki

AU - Overbeek, Ross

AU - Ross, Christian A.

AU - Schioett, Morten

AU - Shippy, Teresa

AU - Takeuchi, Hideaki

AU - Toth, Amy L.

AU - Willis, Judith H.

AU - Wilson, Megan J.

AU - Gordon, Karl H.J.

AU - Letunic, Ivica

AU - Hackett, Kevin

AU - Peterson, Jane

AU - Felsenfeld, Adam

AU - Guyer, Mark

AU - Solignac, Michel

AU - Agarwala, Richa

AU - Cornuet, Jean Marie

AU - Monnerot, Monique

AU - Mougel, Florence

AU - Reese, Justin T.

AU - Vautrin, Dominique

AU - Gillespie, Joseph J.

AU - Cannone, Jamie J.

AU - Gutell, Robin R.

AU - Johnston, J. Spencer

AU - Eisen, Michael B.

AU - Iyer, Venky N.

AU - Iyer, Vivek

AU - Kosarev, Peter

AU - Mackey, Aaron J.

AU - Solovyev, Victor

AU - Souvorov, Alexandre

AU - Aronstein, Katherine A.

AU - Bilikova, Katarina

AU - Chen, Yan Ping

AU - Clark, Andrew G.

AU - Decanini, Laura I.

AU - Gelbart, William M.

AU - Hetru, Charles

AU - Hultmark, Dan

AU - Imler, Jean Luc

AU - Jiang, Haobo

AU - Kanost, Michael

AU - Kimura, Kiyoshi

AU - Lazzaro, Brian P.

AU - Lopez, Dawn L.

AU - Simuth, Jozef

AU - Thompson, Graham J.

AU - Zou, Zhen

AU - De Jong, Pieter

AU - Sodergren, Erica

AU - Csurös, Miklós

AU - Milosavljevic, Aleksandar

AU - Osoegawa, Kazutoyo

AU - Richards, Stephen

AU - Shu, Chung Li

AU - Duret, Laurent

AU - Elhaik, Eran

AU - Graur, Dan

AU - Anzola, Juan M.

AU - Campbell, Kathryn S.

AU - Childs, Kevin L.

AU - Collinge, Derek

AU - Crosby, Madeline A.

AU - Dickens, C. Michael

AU - Grametes, L. Sian

AU - Grozinger, Christina M.

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AU - Miller, Jonathan

AU - Mizzen, Craig

AU - Peinado, Miguel A.

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AU - Russo, Susan M.

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AU - St. Pierre, Susan E.

AU - Wang, Ying

AU - Zhou, Pinglei

AU - Jiang, Huaiyang

AU - Kitts, Paul

AU - Ruef, Barbara

AU - Venkatraman, Anand

AU - Zhang, Lan

AU - Aquino-Perez, Gildardo

AU - Whitfield, Charles W.

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AU - Sheppard, Walter S.

AU - Smith, Deborah R.

AU - Suarez, Andrew V.

AU - Tsutsui, Neil D.

AU - Wei, Xuehong

AU - Wheeler, David

AU - Havlak, Paul

AU - Li, Bingshan

AU - Liu, Yue

AU - Jovilet, Angela

AU - Lee, Sandra

AU - Nazareth, Lynne V.

AU - Pu, Ling Ling

AU - Thorn, Rachel

AU - Stolc, Viktor

AU - Newman, Thomas

AU - Samanta, Manoj

AU - Tongprasit, Waraporn A.

AU - Claudianos, Charles

AU - Berenbaum, May R.

AU - Biswas, Sunita

AU - De Graaf, Dirk C.

AU - Feyereisen, Rene

AU - Johnson, Reed M.

AU - Oakeshott, John G.

AU - Ranson, Hilary

AU - Schuler, Mary A.

AU - Muzny, Donna

AU - Chacko, Joseph

AU - Davis, Clay

AU - Dinh, Huyen

AU - Gill, Rachel

AU - Hernandez, Judith

AU - Hines, Sandra

AU - Hume, Jennifer

AU - Jackson, La Ronda

AU - Kovar, Christie

AU - Lewis, Lora

AU - Miner, George

AU - Morgan, Margaret

AU - Nguyen, Ngoc

AU - Okwuonu, Geoffrey

AU - Paul, Heidi

AU - Santibanez, Jireh

AU - Savery, Glenford

AU - Svatek, Amanda

AU - Villasana, Donna

AU - Wright, Rita

PY - 2006/10/26

Y1 - 2006/10/26

N2 - Here we report the genome sequence of the honeybee Apis mellifera, a key model for social behaviour and essential to global ecology through pollination. Compared with other sequenced insect genomes, the A. mellifera genome has high A+T and CpG contents, lacks major transposon families, evolves more slowly, and is more similar to vertebrates for circadian rhythm, RNA interference and DNA methylation genes, among others. Furthermore, A. mellifera has fewer genes for innate immunity, detoxification enzymes, cuticle-forming proteins and gustatory receptors, more genes for odorant receptors, and novel genes for nectar and pollen utilization, consistent with its ecology and social organization. Compared to Drosophila, genes in early developmental pathways differ in Apis, whereas similarities exist for functions that differ markedly, such as sex determination, brain function and behaviour. Population genetics suggests a novel African origin for the species A. mellifera and insights into whether Africanized bees spread throughout the New World via hybridization or displacement.

AB - Here we report the genome sequence of the honeybee Apis mellifera, a key model for social behaviour and essential to global ecology through pollination. Compared with other sequenced insect genomes, the A. mellifera genome has high A+T and CpG contents, lacks major transposon families, evolves more slowly, and is more similar to vertebrates for circadian rhythm, RNA interference and DNA methylation genes, among others. Furthermore, A. mellifera has fewer genes for innate immunity, detoxification enzymes, cuticle-forming proteins and gustatory receptors, more genes for odorant receptors, and novel genes for nectar and pollen utilization, consistent with its ecology and social organization. Compared to Drosophila, genes in early developmental pathways differ in Apis, whereas similarities exist for functions that differ markedly, such as sex determination, brain function and behaviour. Population genetics suggests a novel African origin for the species A. mellifera and insights into whether Africanized bees spread throughout the New World via hybridization or displacement.

UR - http://www.scopus.com/inward/record.url?scp=33750460281&partnerID=8YFLogxK

U2 - 10.1038/nature05260

DO - 10.1038/nature05260

M3 - Article

VL - 443

SP - 931

EP - 949

JO - Nature: New biology

JF - Nature: New biology

SN - 0028-0836

IS - 7114

ER -

The Honeybee Genome Sequencing Consortium, Collins AM, Kucharski R. Insights into social insects from the genome of the honeybee Apis mellifera. Nature. 2006 Oct 26;443(7114):931-949. https://doi.org/10.1038/nature05260