This paper presents a framework for inter-patient image registration which uses a multi-thresholds, multi-similarity measures and multi-transformations based on compactly supported spline and discrete periodic spline wavelets (DPSWs) using the Gauss-Newton gradient descent (GNGD) and gradient descent (GD) optimization methods. Our primary intellectual contribution is incorporating DPSWs in the transformation while another includes fusing out-of-range concept in a surface matching technique which is implemented by a multi-transformations and multi-similarity measures. In particular, as a true deformation cannot be achieved by single combination of transformation, similarity measure (SM) and optimization of a registration process, a moving image is required to be brought within the range of a registration. On the other hand, the surface matching technique involves an edge position difference (EPD) SM in which coarse to fine surfaces are matched using multiple thresholds with a spline-based free from deformation (FFD) method. The registration experiments were performed on 3D clinical neck magnetic resonance (MR) images, with the results showing that our proposed method provides good accuracy and robustness.