Interferon-induced effector proteins and hepatitis C virus replication

Michael Frese, Eva Dazert

Research output: A Conference proceeding or a Chapter in BookChapter

1 Citation (Scopus)

Abstract

Hepatitis C virus (HCV) is a small, enveloped RNA virus that is often capable of establishing a persistent infection, which may lead to chronic liver disease, cirrhosis, hepatocellular carcinoma, and eventually death. For more than 20 years, hepatitis C patients have been treated with interferon-alpha (IFN-α). Current treatment usually consists of polyethylene glycol-conjugated IFN-α that is combined with ribavirin, but even the most advanced IFN-based therapies are still ineffective in eliminating the virus from a large proportion of individuals. Therefore, a better understanding of the IFN-induced innate immune response is urgently needed. By using selectable self-replicating RNAs (replicons) and, more recently, recombinant full-length genomes, many groups have tried to elucidate the mechanism(s) by which IFNs inhibit HCV replication. This chapter attempts to summarize the current state of knowledge in this interesting field of HCV research
Original languageEnglish
Title of host publicationHepatitis C Virus Disease: Immunobiology and Clinical Applications
EditorsEmilio Jirillo
Place of PublicationNew York, USA
PublisherSpringer
Pages1-12
Number of pages12
Edition1
ISBN (Print)9780387713762
DOIs
Publication statusPublished - 2008

Fingerprint

Virus Replication
Protein C
Interferon-alpha
Hepacivirus
Interferons
Replicon
Ribavirin
RNA Viruses
Hepatitis C
Innate Immunity
Liver Cirrhosis
Liver Diseases
Hepatocellular Carcinoma
Chronic Disease
Genome
RNA
Viruses
Therapeutics
Infection
Research

Cite this

Frese, M., & Dazert, E. (2008). Interferon-induced effector proteins and hepatitis C virus replication. In E. Jirillo (Ed.), Hepatitis C Virus Disease: Immunobiology and Clinical Applications (1 ed., pp. 1-12). New York, USA: Springer. https://doi.org/10.1007/978-0-387-71376-2_6
Frese, Michael ; Dazert, Eva. / Interferon-induced effector proteins and hepatitis C virus replication. Hepatitis C Virus Disease: Immunobiology and Clinical Applications. editor / Emilio Jirillo. 1. ed. New York, USA : Springer, 2008. pp. 1-12
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Frese, M & Dazert, E 2008, Interferon-induced effector proteins and hepatitis C virus replication. in E Jirillo (ed.), Hepatitis C Virus Disease: Immunobiology and Clinical Applications. 1 edn, Springer, New York, USA, pp. 1-12. https://doi.org/10.1007/978-0-387-71376-2_6

Interferon-induced effector proteins and hepatitis C virus replication. / Frese, Michael; Dazert, Eva.

Hepatitis C Virus Disease: Immunobiology and Clinical Applications. ed. / Emilio Jirillo. 1. ed. New York, USA : Springer, 2008. p. 1-12.

Research output: A Conference proceeding or a Chapter in BookChapter

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AB - Hepatitis C virus (HCV) is a small, enveloped RNA virus that is often capable of establishing a persistent infection, which may lead to chronic liver disease, cirrhosis, hepatocellular carcinoma, and eventually death. For more than 20 years, hepatitis C patients have been treated with interferon-alpha (IFN-α). Current treatment usually consists of polyethylene glycol-conjugated IFN-α that is combined with ribavirin, but even the most advanced IFN-based therapies are still ineffective in eliminating the virus from a large proportion of individuals. Therefore, a better understanding of the IFN-induced innate immune response is urgently needed. By using selectable self-replicating RNAs (replicons) and, more recently, recombinant full-length genomes, many groups have tried to elucidate the mechanism(s) by which IFNs inhibit HCV replication. This chapter attempts to summarize the current state of knowledge in this interesting field of HCV research

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Frese M, Dazert E. Interferon-induced effector proteins and hepatitis C virus replication. In Jirillo E, editor, Hepatitis C Virus Disease: Immunobiology and Clinical Applications. 1 ed. New York, USA: Springer. 2008. p. 1-12 https://doi.org/10.1007/978-0-387-71376-2_6