Interindividual variation in epigenomic phenomena in humans

Hugh French, Rosalind Attenborough, Kristine Hardy, Frances Shannon, Rohan Williams

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Our knowledge of regulatory mechanisms of gene expression and other chromosomal processes related to DNA methylation and chromatin state is continuing to grow at a rapid pace. Understanding how these epigenomic phenomena vary between individuals will have an impact on understanding their broader role in determining variation in gene expression and biochemical, physiological, and behavioural phenotypes. In this review we survey recent progress in this area, focusing on data available from humans. We highlight the role of obligatory (sequence-dependent) epigenomic variation as an important mechanism for generating interindividual variation that could impact our understanding of the mechanistic basis of complex trait architecture
Original languageEnglish
Pages (from-to)604-611
Number of pages8
JournalMammalian Genome
Volume90
Issue number9/10/2011
DOIs
Publication statusPublished - 2009

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French, H., Attenborough, R., Hardy, K., Shannon, F., & Williams, R. (2009). Interindividual variation in epigenomic phenomena in humans. Mammalian Genome, 90(9/10/2011), 604-611. https://doi.org/10.1007/s00335-009-9219-0