Intestinal mucositis: The role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage

Joanne M. Bowen; Rachel J. Gibson; Adrian G. Cummins; Dorothy M.K. Keefe

doi:10.1007/s00520-005-0004-7

Intestinal mucositis: The role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage

Joanne M. Bowen, Rachel J. Gibson, Adrian G. Cummins, Dorothy M.K. Keefe

Research output: Contribution to journal › Review article › peer-review

102 Citations (Scopus)

Abstract

Intestinal mucositis occurs as a consequence of cytotoxic treatment through multiple mechanisms including induction of crypt cell death (apoptosis) and cytostasis. The molecular control of these actions throughout the gastrointestinal tract has yet to be fully elucidated; however, they are known to involve p53, the Bcl-2 family and caspases. This review will provide an overview of current research as well as identify areas where gaps in knowledge exist.

Original language	English
Pages (from-to)	713-731
Number of pages	19
Journal	Supportive Care in Cancer
Volume	14
Issue number	7
DOIs	https://doi.org/10.1007/s00520-005-0004-7
Publication status	Published - Jul 2006
Externally published	Yes

Access to Document

10.1007/s00520-005-0004-7

Cite this

@article{32565af0647e4cd582824b6787edd1df,

title = "Intestinal mucositis: The role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage",

abstract = "Intestinal mucositis occurs as a consequence of cytotoxic treatment through multiple mechanisms including induction of crypt cell death (apoptosis) and cytostasis. The molecular control of these actions throughout the gastrointestinal tract has yet to be fully elucidated; however, they are known to involve p53, the Bcl-2 family and caspases. This review will provide an overview of current research as well as identify areas where gaps in knowledge exist.",

keywords = "Bcl-2 family, Caspases, Mucositis, p53",

author = "Bowen, {Joanne M.} and Gibson, {Rachel J.} and Cummins, {Adrian G.} and Keefe, {Dorothy M.K.}",

year = "2006",

month = jul,

doi = "10.1007/s00520-005-0004-7",

language = "English",

volume = "14",

pages = "713--731",

journal = "Supportive Care in Cancer",

issn = "0941-4355",

publisher = "Springer",

number = "7",

}

TY - JOUR

T1 - Intestinal mucositis

T2 - The role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage

AU - Bowen, Joanne M.

AU - Gibson, Rachel J.

AU - Cummins, Adrian G.

AU - Keefe, Dorothy M.K.

PY - 2006/7

Y1 - 2006/7

N2 - Intestinal mucositis occurs as a consequence of cytotoxic treatment through multiple mechanisms including induction of crypt cell death (apoptosis) and cytostasis. The molecular control of these actions throughout the gastrointestinal tract has yet to be fully elucidated; however, they are known to involve p53, the Bcl-2 family and caspases. This review will provide an overview of current research as well as identify areas where gaps in knowledge exist.

AB - Intestinal mucositis occurs as a consequence of cytotoxic treatment through multiple mechanisms including induction of crypt cell death (apoptosis) and cytostasis. The molecular control of these actions throughout the gastrointestinal tract has yet to be fully elucidated; however, they are known to involve p53, the Bcl-2 family and caspases. This review will provide an overview of current research as well as identify areas where gaps in knowledge exist.

KW - Bcl-2 family

KW - Caspases

KW - Mucositis

KW - p53

UR - http://www.scopus.com/inward/record.url?scp=33745107459&partnerID=8YFLogxK

U2 - 10.1007/s00520-005-0004-7

DO - 10.1007/s00520-005-0004-7

M3 - Review article

C2 - 16453135

AN - SCOPUS:33745107459

SN - 0941-4355

VL - 14

SP - 713

EP - 731

JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

IS - 7

ER -

Intestinal mucositis: The role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage

Abstract

Access to Document

Other files and links

Fingerprint

Cite this