Investigation of scattered dose in a mouse phantom model for pre-clinical dosimetry studies

Amir Entezam; Andrew Fielding; Davide Moi; David Bradley; Gishan Ratnayake; Lucy Sim; Chelsea Kralik; Davide Fontanarosa

doi:10.1016/j.radphyschem.2021.109691

Investigation of scattered dose in a mouse phantom model for pre-clinical dosimetry studies

Amir Entezam, Andrew Fielding, Davide Moi, David Bradley, Gishan Ratnayake, Lucy Sim, Chelsea Kralik, Davide Fontanarosa

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Tissue-equivalent phantoms are suitable tools for radiation dosimetry investigations. The goal of this study was to determine the scattered dose in a simple phantom model of a mouse with a xenographic tumour using experimental dose measurements and Monte-Carlo calculations. We manufactured a cubic polymethyl methacrylate (PMMA) phantom with an extrusion on its side to model both normal tissue and xenograft tumour of a tumour-bearing mouse. The phantom was positioned in a novel add-on collimator, designed by our research group, to enable targeted irradiation of the xenograft tumour with a dose of 20 Gy using a¹³⁷Cs gamma irradiator. EBT3 GAFchromic film was utilized to measure the dose distribution within the phantom. EGSnrc MC code was used to simulate the irradiation system and to calculate the dose distribution in the phantom for comparison with the film dose measurements. Good agreement was observed between film dose measurements and simulation results based on gamma index analysis. The results demonstrate that the out of field dose (dose to the normal tissue) is of the order 8–9% of the prescribed dose when irradiating the xenographic tumour of the phantom. Our physical phantom is a useful tool to assess the out of field dose when irradiating xenographic tumours.

Original language	English
Article number	109691
Pages (from-to)	1-9
Number of pages	9
Journal	Radiation Physics and Chemistry
Volume	189
DOIs	https://doi.org/10.1016/j.radphyschem.2021.109691
Publication status	Published - Dec 2021
Externally published	Yes

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10.1016/j.radphyschem.2021.109691

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title = "Investigation of scattered dose in a mouse phantom model for pre-clinical dosimetry studies",

abstract = "Tissue-equivalent phantoms are suitable tools for radiation dosimetry investigations. The goal of this study was to determine the scattered dose in a simple phantom model of a mouse with a xenographic tumour using experimental dose measurements and Monte-Carlo calculations. We manufactured a cubic polymethyl methacrylate (PMMA) phantom with an extrusion on its side to model both normal tissue and xenograft tumour of a tumour-bearing mouse. The phantom was positioned in a novel add-on collimator, designed by our research group, to enable targeted irradiation of the xenograft tumour with a dose of 20 Gy using a137Cs gamma irradiator. EBT3 GAFchromic film was utilized to measure the dose distribution within the phantom. EGSnrc MC code was used to simulate the irradiation system and to calculate the dose distribution in the phantom for comparison with the film dose measurements. Good agreement was observed between film dose measurements and simulation results based on gamma index analysis. The results demonstrate that the out of field dose (dose to the normal tissue) is of the order 8–9% of the prescribed dose when irradiating the xenographic tumour of the phantom. Our physical phantom is a useful tool to assess the out of field dose when irradiating xenographic tumours.",

keywords = "Add-on collimator, Gamma index, Monte Carlo simulations, Mouse phantom, Small animal irradiation, Xenographic tumour model",

author = "Amir Entezam and Andrew Fielding and Davide Moi and David Bradley and Gishan Ratnayake and Lucy Sim and Chelsea Kralik and Davide Fontanarosa",

note = "Funding Information: This work was supported by Queensland University of Technology grant (Institute of Health and Biomedical Innovation (IHBI) John Williams Cancer Research Scholar). Publisher Copyright: {\textcopyright} 2021",

year = "2021",

month = dec,

doi = "10.1016/j.radphyschem.2021.109691",

language = "English",

volume = "189",

pages = "1--9",

journal = "Radiation Physics and Chemistry",

issn = "0969-806X",

publisher = "Elsevier Limited",

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T1 - Investigation of scattered dose in a mouse phantom model for pre-clinical dosimetry studies

AU - Entezam, Amir

AU - Fielding, Andrew

AU - Moi, Davide

AU - Bradley, David

AU - Ratnayake, Gishan

AU - Sim, Lucy

AU - Kralik, Chelsea

AU - Fontanarosa, Davide

N1 - Funding Information: This work was supported by Queensland University of Technology grant (Institute of Health and Biomedical Innovation (IHBI) John Williams Cancer Research Scholar). Publisher Copyright: © 2021

PY - 2021/12

Y1 - 2021/12

N2 - Tissue-equivalent phantoms are suitable tools for radiation dosimetry investigations. The goal of this study was to determine the scattered dose in a simple phantom model of a mouse with a xenographic tumour using experimental dose measurements and Monte-Carlo calculations. We manufactured a cubic polymethyl methacrylate (PMMA) phantom with an extrusion on its side to model both normal tissue and xenograft tumour of a tumour-bearing mouse. The phantom was positioned in a novel add-on collimator, designed by our research group, to enable targeted irradiation of the xenograft tumour with a dose of 20 Gy using a137Cs gamma irradiator. EBT3 GAFchromic film was utilized to measure the dose distribution within the phantom. EGSnrc MC code was used to simulate the irradiation system and to calculate the dose distribution in the phantom for comparison with the film dose measurements. Good agreement was observed between film dose measurements and simulation results based on gamma index analysis. The results demonstrate that the out of field dose (dose to the normal tissue) is of the order 8–9% of the prescribed dose when irradiating the xenographic tumour of the phantom. Our physical phantom is a useful tool to assess the out of field dose when irradiating xenographic tumours.

AB - Tissue-equivalent phantoms are suitable tools for radiation dosimetry investigations. The goal of this study was to determine the scattered dose in a simple phantom model of a mouse with a xenographic tumour using experimental dose measurements and Monte-Carlo calculations. We manufactured a cubic polymethyl methacrylate (PMMA) phantom with an extrusion on its side to model both normal tissue and xenograft tumour of a tumour-bearing mouse. The phantom was positioned in a novel add-on collimator, designed by our research group, to enable targeted irradiation of the xenograft tumour with a dose of 20 Gy using a137Cs gamma irradiator. EBT3 GAFchromic film was utilized to measure the dose distribution within the phantom. EGSnrc MC code was used to simulate the irradiation system and to calculate the dose distribution in the phantom for comparison with the film dose measurements. Good agreement was observed between film dose measurements and simulation results based on gamma index analysis. The results demonstrate that the out of field dose (dose to the normal tissue) is of the order 8–9% of the prescribed dose when irradiating the xenographic tumour of the phantom. Our physical phantom is a useful tool to assess the out of field dose when irradiating xenographic tumours.

KW - Add-on collimator

KW - Gamma index

KW - Monte Carlo simulations

KW - Mouse phantom

KW - Small animal irradiation

KW - Xenographic tumour model

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ER -

Investigation of scattered dose in a mouse phantom model for pre-clinical dosimetry studies

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