TY - JOUR
T1 - Is Non-Alcoholic Fatty Liver Disease Connected with Cognition?
T2 - The Complex Interplay between Liver and Brain
AU - Kouvari, Matina
AU - Sergi, Domenico
AU - D'Cunha, Nathan M
AU - Bulman, Amanda
AU - Panagiotakos, Demosthenes B.
AU - Naumovski, Nenad
N1 - Funding Information:
This research received no external funcing.
Publisher Copyright:
© 2022 by the authors.
PY - 2022/6/14
Y1 - 2022/6/14
N2 - The prevalence of non-alcoholic fatty liver disease (NAFLD) and its progressive form, non-alcoholic steatohepatitis (NASH), is increasing in parallel with the rising rates of obesity and type 2 diabetes. Approximately one in four adults are diagnosed with liver steatosis globally. NAFLD is associated with insulin resistance, hypertension, obesity, visceral adiposity, and dyslipidaemia. These risk factors are often accompanied by inflammation and oxidative stress, which also play a role in extrahepatic diseases, including conditions related to the central nervous system, such as mild cognitive impairment and Alzheimer’s disease. The number of people living with dementia is approximately 55 million and is estimated to increase to approximately 2 billion people by 2050. Recent studies have found that NAFLD is associated with poorer cognition. The aim of this review was to summarise the findings of hitherto studies that have linked NAFLD with cognition and dementia, as well as to discuss the potential liver–brain pathways.
AB - The prevalence of non-alcoholic fatty liver disease (NAFLD) and its progressive form, non-alcoholic steatohepatitis (NASH), is increasing in parallel with the rising rates of obesity and type 2 diabetes. Approximately one in four adults are diagnosed with liver steatosis globally. NAFLD is associated with insulin resistance, hypertension, obesity, visceral adiposity, and dyslipidaemia. These risk factors are often accompanied by inflammation and oxidative stress, which also play a role in extrahepatic diseases, including conditions related to the central nervous system, such as mild cognitive impairment and Alzheimer’s disease. The number of people living with dementia is approximately 55 million and is estimated to increase to approximately 2 billion people by 2050. Recent studies have found that NAFLD is associated with poorer cognition. The aim of this review was to summarise the findings of hitherto studies that have linked NAFLD with cognition and dementia, as well as to discuss the potential liver–brain pathways.
KW - Cognition
KW - Liver steatosis
KW - Non-alcoholic steatohepatitis
KW - Dementia
KW - Diabetes
KW - non-alcoholic fatty liver disease
KW - cognition
KW - dementia
KW - liver steatosis
KW - diabetes
UR - http://www.scopus.com/inward/record.url?scp=85148907720&partnerID=8YFLogxK
U2 - https://doi.org/10.3390/diabetology3020026
DO - https://doi.org/10.3390/diabetology3020026
M3 - Review article
VL - 3
SP - 355
EP - 363
JO - Diabetology
JF - Diabetology
IS - 2
ER -
