Is salivary cortisol moderating the relationship between salivary testosterone and hand-grip strength in healthy men?

Blair T Crewther, Andrew G Thomas, Steve Stewart-Williams, Liam P Kilduff, Christian J Cook

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Abstract

    This study examined the moderating effect of cortisol (C) on the relationship between testosterone (T) and hand-grip strength (HGS) in healthy young men. Sixty-five males were monitored for salivary T, C and HGS before and 15 min after a short bout (5 × 6-s trials) of sprint cycling exercise. Sprint exercise promoted (p < .05) positive changes in T (6.1 ± 24.9%) and HGS (3.4 ± 7.5%), but a negative C response (-14.4 ± 33.1%). The T and C measures did not independently predict HGS, but a significant T × C interaction was found in relation to these outcomes. Further testing revealed that pre-test T and HGS were negatively associated (p < .05), but only in men with high C levels. The exercise changes in T and HGS were also negatively related in men with low C levels (p < .05), but no relationship was seen in men with high C levels. In summary, complex relationships between T and HGS emerged when considering C as a moderating variable. The pre-test combination of high C and low T levels favoured absolute HGS, whereas low pre-test C levels and a smaller T change were linked to larger HGS changes. These associations suggest that, in the current format, T is not necessarily anabolic to muscle strength in healthy young men. Such complexities could also explain some of the inconsistent T relationships with physical performance in lesser trained male populations.

    Original languageEnglish
    Pages (from-to)188-194
    Number of pages7
    JournalEuropean Journal of Sport Science
    Volume17
    Issue number2
    DOIs
    Publication statusPublished - Mar 2017

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    Hand Strength
    Hydrocortisone
    Testosterone
    Exercise
    Muscle Strength

    Cite this

    Crewther, Blair T ; Thomas, Andrew G ; Stewart-Williams, Steve ; Kilduff, Liam P ; Cook, Christian J. / Is salivary cortisol moderating the relationship between salivary testosterone and hand-grip strength in healthy men?. In: European Journal of Sport Science. 2017 ; Vol. 17, No. 2. pp. 188-194.
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    abstract = "This study examined the moderating effect of cortisol (C) on the relationship between testosterone (T) and hand-grip strength (HGS) in healthy young men. Sixty-five males were monitored for salivary T, C and HGS before and 15 min after a short bout (5 × 6-s trials) of sprint cycling exercise. Sprint exercise promoted (p < .05) positive changes in T (6.1 ± 24.9{\%}) and HGS (3.4 ± 7.5{\%}), but a negative C response (-14.4 ± 33.1{\%}). The T and C measures did not independently predict HGS, but a significant T × C interaction was found in relation to these outcomes. Further testing revealed that pre-test T and HGS were negatively associated (p < .05), but only in men with high C levels. The exercise changes in T and HGS were also negatively related in men with low C levels (p < .05), but no relationship was seen in men with high C levels. In summary, complex relationships between T and HGS emerged when considering C as a moderating variable. The pre-test combination of high C and low T levels favoured absolute HGS, whereas low pre-test C levels and a smaller T change were linked to larger HGS changes. These associations suggest that, in the current format, T is not necessarily anabolic to muscle strength in healthy young men. Such complexities could also explain some of the inconsistent T relationships with physical performance in lesser trained male populations.",
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    Is salivary cortisol moderating the relationship between salivary testosterone and hand-grip strength in healthy men? / Crewther, Blair T; Thomas, Andrew G; Stewart-Williams, Steve; Kilduff, Liam P; Cook, Christian J.

    In: European Journal of Sport Science, Vol. 17, No. 2, 03.2017, p. 188-194.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Is salivary cortisol moderating the relationship between salivary testosterone and hand-grip strength in healthy men?

    AU - Crewther, Blair T

    AU - Thomas, Andrew G

    AU - Stewart-Williams, Steve

    AU - Kilduff, Liam P

    AU - Cook, Christian J

    PY - 2017/3

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    N2 - This study examined the moderating effect of cortisol (C) on the relationship between testosterone (T) and hand-grip strength (HGS) in healthy young men. Sixty-five males were monitored for salivary T, C and HGS before and 15 min after a short bout (5 × 6-s trials) of sprint cycling exercise. Sprint exercise promoted (p < .05) positive changes in T (6.1 ± 24.9%) and HGS (3.4 ± 7.5%), but a negative C response (-14.4 ± 33.1%). The T and C measures did not independently predict HGS, but a significant T × C interaction was found in relation to these outcomes. Further testing revealed that pre-test T and HGS were negatively associated (p < .05), but only in men with high C levels. The exercise changes in T and HGS were also negatively related in men with low C levels (p < .05), but no relationship was seen in men with high C levels. In summary, complex relationships between T and HGS emerged when considering C as a moderating variable. The pre-test combination of high C and low T levels favoured absolute HGS, whereas low pre-test C levels and a smaller T change were linked to larger HGS changes. These associations suggest that, in the current format, T is not necessarily anabolic to muscle strength in healthy young men. Such complexities could also explain some of the inconsistent T relationships with physical performance in lesser trained male populations.

    AB - This study examined the moderating effect of cortisol (C) on the relationship between testosterone (T) and hand-grip strength (HGS) in healthy young men. Sixty-five males were monitored for salivary T, C and HGS before and 15 min after a short bout (5 × 6-s trials) of sprint cycling exercise. Sprint exercise promoted (p < .05) positive changes in T (6.1 ± 24.9%) and HGS (3.4 ± 7.5%), but a negative C response (-14.4 ± 33.1%). The T and C measures did not independently predict HGS, but a significant T × C interaction was found in relation to these outcomes. Further testing revealed that pre-test T and HGS were negatively associated (p < .05), but only in men with high C levels. The exercise changes in T and HGS were also negatively related in men with low C levels (p < .05), but no relationship was seen in men with high C levels. In summary, complex relationships between T and HGS emerged when considering C as a moderating variable. The pre-test combination of high C and low T levels favoured absolute HGS, whereas low pre-test C levels and a smaller T change were linked to larger HGS changes. These associations suggest that, in the current format, T is not necessarily anabolic to muscle strength in healthy young men. Such complexities could also explain some of the inconsistent T relationships with physical performance in lesser trained male populations.

    KW - Adolescent

    KW - Adult

    KW - Cohort Studies

    KW - Hand Strength

    KW - Humans

    KW - Hydrocortisone

    KW - Male

    KW - Models, Statistical

    KW - Random Allocation

    KW - Saliva

    KW - Testosterone

    KW - Young Adult

    KW - Journal Article

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    DO - 10.1080/17461391.2016.1220628

    M3 - Article

    VL - 17

    SP - 188

    EP - 194

    JO - European Journal of Sport Science

    JF - European Journal of Sport Science

    SN - 1536-7290

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    ER -