Jostling for position in angiogenic sprouts: Continuous rearrangement of cells explained by differential adhesion dynamics

Lauren WILLIAMS, Tanya LAWLIS

Research output: A Conference proceeding or a Chapter in BookChapter

2 Citations (Scopus)

Abstract

Endothelial sprouting during angiogenesis is a highly coordinated morphogenetic process that involves polarized tip cells leading stalk cells to form new capillaries. While tip and stalk cells previously were thought to be stable and have static phenotypes within the sprout, it is becoming increasingly clear that endothelial cells undergo dynamic rearrangements. A new study using computer simulations, validated by in vitro and in vivo experimental data, now provides an explanation for these rearrangements, showing that sprouting cells are in a continuum of migratory states, regulated by differential cell-cell adhesions and protrusive activities to drive proper vascular organization. Gerhardt and colleagues establish intrinsic cellular adhesion dynamics as functional determinant for cell fate and cell positioning during angiogenesis.

Original languageEnglish
Title of host publicationSecond Opinion: An introduction to health sociology
EditorsJohn Germov
Place of PublicationVictoria
PublisherOxford University Press Australia and New Zealand
Chapter23
Pages1089-1090
Number of pages2
Volume33
Edition10
ISBN (Print)9780195520149
DOIs
Publication statusPublished - 16 May 2014

Publication series

NameEMBO Journal
PublisherWiley-Blackwell
ISSN (Print)0261-4189

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