Kit ligand and c-Kit have diverse roles during mammalian oogenesis and folliculogenesis

K. J. Hutt, Eileen A. McLaughlin, M. K. Holland

Research output: Contribution to journalReview article

122 Citations (Scopus)

Abstract

Paracrine signalling between the oocyte and its surrounding somatic cells is fundamental to the processes of oogenesis and folliculogenesis in mammals. The study of animal models has revealed that the interaction of granulosa cell-derived kit ligand (KL) with oocyte and theca cell-derived c-Kit is important for multiple aspects of oocyte and follicle development, including the establishment of primordial germ cells within the ovary, primordial follicle activation, oocyte survival and growth, granulosa cell proliferation, theca cell recruitment and the maintenance of meiotic arrest. Though little is known about the specific roles of KL and c-Kit during human oogenesis, the expression profiles for KL and c-Kit within the human ovary suggest that they are also functionally relevant to female fertility. This review details our current understanding of the roles of KL and c-Kit within the mammalian ovary, with a particular focus on the functional diversity of this receptor-ligand interaction at different stages of oocyte and follicle development.

Original languageEnglish
Pages (from-to)61-69
Number of pages9
JournalMolecular Human Reproduction
Volume12
Issue number2
DOIs
Publication statusPublished - 15 Feb 2006
Externally publishedYes

Fingerprint

Oogenesis
Stem Cell Factor
Oocytes
Theca Cells
Ovary
Granulosa Cells
Paracrine Communication
Germ Cells
Fertility
Mammals
Animal Models
Maintenance
Cell Proliferation
Ligands
Growth

Cite this

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title = "Kit ligand and c-Kit have diverse roles during mammalian oogenesis and folliculogenesis",
abstract = "Paracrine signalling between the oocyte and its surrounding somatic cells is fundamental to the processes of oogenesis and folliculogenesis in mammals. The study of animal models has revealed that the interaction of granulosa cell-derived kit ligand (KL) with oocyte and theca cell-derived c-Kit is important for multiple aspects of oocyte and follicle development, including the establishment of primordial germ cells within the ovary, primordial follicle activation, oocyte survival and growth, granulosa cell proliferation, theca cell recruitment and the maintenance of meiotic arrest. Though little is known about the specific roles of KL and c-Kit during human oogenesis, the expression profiles for KL and c-Kit within the human ovary suggest that they are also functionally relevant to female fertility. This review details our current understanding of the roles of KL and c-Kit within the mammalian ovary, with a particular focus on the functional diversity of this receptor-ligand interaction at different stages of oocyte and follicle development.",
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Kit ligand and c-Kit have diverse roles during mammalian oogenesis and folliculogenesis. / Hutt, K. J.; McLaughlin, Eileen A.; Holland, M. K.

In: Molecular Human Reproduction, Vol. 12, No. 2, 15.02.2006, p. 61-69.

Research output: Contribution to journalReview article

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N2 - Paracrine signalling between the oocyte and its surrounding somatic cells is fundamental to the processes of oogenesis and folliculogenesis in mammals. The study of animal models has revealed that the interaction of granulosa cell-derived kit ligand (KL) with oocyte and theca cell-derived c-Kit is important for multiple aspects of oocyte and follicle development, including the establishment of primordial germ cells within the ovary, primordial follicle activation, oocyte survival and growth, granulosa cell proliferation, theca cell recruitment and the maintenance of meiotic arrest. Though little is known about the specific roles of KL and c-Kit during human oogenesis, the expression profiles for KL and c-Kit within the human ovary suggest that they are also functionally relevant to female fertility. This review details our current understanding of the roles of KL and c-Kit within the mammalian ovary, with a particular focus on the functional diversity of this receptor-ligand interaction at different stages of oocyte and follicle development.

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